MR SPECTROSCOPY OF SIV BRAIN INJURY

SIV 脑损伤的 MR 光谱

• 批准号: 7715474
• 负责人: Shawn Patrick O'Neil
• 金额: $ 1.3万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715474
• 关键词: AIDS Dementia Complex; Acquired Immunodeficiency Syndrome; Anti-Retroviral Agents; Brain; Brain Injuries; Computer Retrieval of Information on Scientific Projects Database; Condition; Funding; Grant; HIV; HIV Seropositivity; Highly Active Antiretroviral Therapy; Incidence; Individual; Institution; Lesion; Lymphoid; Macaca mulatta; Measures; Modeling; Nerve Tissue; Neurologic; Organ; Outcome; Patients; Research; Research Personnel; Resources; SIV encephalitis; Source; Spectrum Analysis; Tissues; United States National Institutes of Health; Viral; Viral Load result; Virus; antiretroviral therapy; brain tissue

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Like lymphoid organs, the CNS is an important tissue reservoir for HIV. HIV-related neurological conditions, including HIV-associated dementia, are known to occur as a result of viral replication and persistence in the CNS of HIV-infected individuals. Highly active antiretroviral therapy (HAART) has reduced the incidence of HIV dementia as well as most of the other neurological complications of AIDS, presumably by suppressing viral replication in nervous tissues. However, it has been difficult to measure the effect of antiretroviral treatment on viral load in brain tissue directly, as well as the impact of HAART on the outcome of encephalitic lesions in the CNS of HIV positive patients, because brain tissue is not readily accessible for analysis. We are using the CD8-depletion model of SIV encephalitis (SIVE) in rhesus monkeys to directly measure the impact of combination antiretroviral therapy (CART) on brain virus burden.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 像淋巴器官一样，CNS是HIV的重要组织储存库。 HIV相关的神经系统疾病，包括HIV相关的痴呆，已知是由于HIV感染个体的CNS中的病毒复制和持续存在而发生的。 高效抗逆转录病毒疗法（HAART）可能通过抑制病毒在神经组织中的复制，降低了艾滋病毒痴呆症以及艾滋病的大多数其他神经系统并发症的发生率。 然而，它一直难以直接测量抗逆转录病毒治疗对脑组织中病毒载量的影响，以及HAART对HIV阳性患者CNS中脑炎病变的结果的影响，因为脑组织不容易进行分析。 我们正在使用恒河猴SIV脑炎（SIVE）的CD 8耗竭模型来直接测量联合抗逆转录病毒治疗（CART）对脑病毒负荷的影响。