MR SPECTROSCOPY OF SIV BRAIN INJURY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 像淋巴器官一样，中枢神经系统是艾滋病毒的重要组织储存库。众所周知，艾滋病毒相关的神经系统疾病，包括艾滋病毒相关性痴呆，是艾滋病毒感染者中枢神经系统内病毒复制和持续存在的结果。高效抗逆转录病毒疗法(HAART)通过抑制神经组织中的病毒复制，减少了艾滋病毒痴呆症和艾滋病的大多数其他神经系统并发症的发生率。然而，直接测量抗逆转录病毒治疗对脑组织中病毒载量的影响，以及HAART对HIV阳性患者中枢神经系统脑炎损害结果的影响一直是困难的，因为难以接触到脑组织进行分析。我们正在使用恒河猴SIV脑炎(SIVE)的CD8耗尽模型来直接测量联合抗逆转录病毒疗法(CART)对脑病毒负荷的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Like lymphoid organs, the CNS is an important tissue reservoir for HIV. HIV-related neurological conditions, including HIV-associated dementia, are known to occur as a result of viral replication and persistence in the CNS of HIV-infected individuals. Highly active antiretroviral therapy (HAART) has reduced the incidence of HIV dementia as well as most of the other neurological complications of AIDS, presumably by suppressing viral replication in nervous tissues. However, it has been difficult to measure the effect of antiretroviral treatment on viral load in brain tissue directly, as well as the impact of HAART on the outcome of encephalitic lesions in the CNS of HIV positive patients, because brain tissue is not readily accessible for analysis. We are using the CD8-depletion model of SIV encephalitis (SIVE) in rhesus monkeys to directly measure the impact of combination antiretroviral therapy (CART) on brain virus burden.