AIDS AND OPIATES: A MONKEY MODEL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 静脉药物滥用是艾滋病毒感染和艾滋病的一个突出危险因素。 可以找到可靠的证据表明，阿片类药物对艾滋病没有影响，加剧甚至抑制艾滋病的进展。 在一项使用猴免疫缺陷病毒（SIV）感染恒河猴模型的初步研究中，我们发现吗啡依赖减缓了艾滋病的进展。 我们随后启动了一项试验，以进一步调查阿片类药物依赖和艾滋病进展之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. IV-drug abuse is a prominent risk factor for HIV infection and AIDS. Credible support can be found that opiates have no effect, exacerbate, or even inhibit AIDS progression. In a pilot study using the simian immunodeficiency virus (SIV) infected rhesus macaque model, we found that AIDS progression was slowed by morphine dependency. We have subsequently initiated a trial to further investigate the relationship between opiate dependency and AIDS progression.