AIDS AND OPIATES: A MONKEY MODEL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 静脉药物滥用是艾滋病毒感染和艾滋病的一个突出的危险因素。可靠的证据表明，鸦片类药物没有任何效果，甚至会加剧甚至抑制艾滋病的发展。在一项使用猴免疫缺陷病毒(SIV)感染恒河猴模型的初步研究中，我们发现吗啡依赖会减缓艾滋病的进展。我们随后启动了一项试验，以进一步调查阿片类药物依赖和艾滋病进展之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. IV-drug abuse is a prominent risk factor for HIV infection and AIDS. Credible support can be found that opiates have no effect, exacerbate, or even inhibit AIDS progression. In a pilot study using the simian immunodeficiency virus (SIV) infected rhesus macaque model, we found that AIDS progression was slowed by morphine dependency. We have subsequently initiated a trial to further investigate the relationship between opiate dependency and AIDS progression.