MOLECULAR GENETIC MARKERS IN PRIMATE DISEASE MODELS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nonhuman primates are a critical component of biomedical research, as animal models for many human diseases. Increased genetic information about nonhuman primate animal models will expand opportunities for disease-related research. As the genetic characterization of primates progresses, future research projects using these species will be able to more fully investigate relationships between genetics and disease. The first objective of this project is to add new genetic polymorphisms to the existing baboon genetic linkage map. The second objective is to identify additional genetic polymorphisms in rhesus monkeys and add them to the rhesus linkage map. We have identified new genetic markers to fill several existing gaps in the baboon linkage map. This project will improve the value of baboons and rhesus for a wide variety of disease studies related to heart disease, obesity, psychiatric disorders, osteoporosis and infectious disease, including AIDS.