FUNCTIONAL BRAIN IMAGING IN BABOONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在对狒狒进行PET成像，以量化在行为挑战期间和之后局部大脑活动的个体差异。这些狒狒将被关在SNPRC的一个笼子里过夜，然后在意识清醒的情况下被运送到UTHSC-SA的研究成像中心。交通将由SNPRC面包车运送。这种乘坐面包车的经历对动物来说会有轻微的压力，一旦到达成像中心，我们将量化杏仁核、前额叶皮质和大脑其他区域大脑新陈代谢的个体差异。研究对象将从先前研究中已经测试过对新奇事物的反应的动物中选择。因此，我们将能够选择一些对新奇事物高度反应的动物，以及其他行为更稳定、反应较少的动物。这将使我们能够确定哪些大脑区域在应对运输挑战时代谢活动的差异最大，以及哪些大脑区域在挑战期间的代谢激活与对新奇事物的行为反应之间显示出强烈的相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are conducting PET imaging of baboons to quantify individual differences in regional brain activity during and after a behavioral challenge. The baboons will be housed overnight in single cages, at SNPRC, and then transported while conscious to the Research Imaging Center at UTHSC-SA. Transportation will be by SNPRC van. This experience of riding in the van will be mildly stressful to the animals, and we will quantify individual differences in brain metabolism in the amygdala, prefrontal cortex and other regions of the brain once they arrive at the imaging center. Study subjects will be chosen from among animals already tested for response to novelty in a previous study. Therefore, we will be able to select some animals that score as highly reactivity to novelty and others that are more stable and less reactive behaviorally. This will allow us to determine which brain regions show the greatest variance in metabolic activity in response to this transportation challenge, and which brain regions show strong correlations between metabolic activation during challenge and behavioral responses to novelty.