FUNCTIONAL BRAIN IMAGING IN BABOONS

狒狒的功能性脑成像

• 批准号: 7957927
• 负责人: JEFFREY A. ROGERS
• 金额: $ 0.63万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-06 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957927
• 关键词: Amygdaloid structure; Animals; Behavioral; Brain; Brain imaging; Brain region; Computer Retrieval of Information on Scientific Projects Database; Conscious; Funding; Grant; Housing; Image; Individual Differences; Institution; Metabolic; Metabolic Activation; Papio; Positron-Emission Tomography; Prefrontal Cortex; Primates; Research; Research Personnel; Resources; Source; Study Subject; Testing; Transportation; United States National Institutes of Health; brain metabolism; experience; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are conducting PET imaging of baboons to quantify individual differences in regional brain activity during and after a behavioral challenge. The baboons will be housed overnight in single cages, at SNPRC, and then transported while conscious to the Research Imaging Center at UTHSC-SA. Transportation will be by SNPRC van. This experience of riding in the van will be mildly stressful to the animals, and we will quantify individual differences in brain metabolism in the amygdala, prefrontal cortex and other regions of the brain once they arrive at the imaging center. Study subjects will be chosen from among animals already tested for response to novelty in a previous study. Therefore, we will be able to select some animals that score as highly reactivity to novelty and others that are more stable and less reactive behaviorally. This will allow us to determine which brain regions show the greatest variance in metabolic activity in response to this transportation challenge, and which brain regions show strong correlations between metabolic activation during challenge and behavioral responses to novelty.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们正在对狒狒进行 PET 成像，以量化行为挑战期间和之后区域大脑活动的个体差异。 这些狒狒将被安置在 SNPRC 的单笼中过夜，然后在意识清醒的情况下被运送到南澳大学医学中心的成像研究中心。 交通将使用 SNPRC 货车。 这种乘坐面包车的经历会给动物带来轻微的压力，一旦它们到达成像中心，我们将量化杏仁核、前额叶皮层和大脑其他区域的大脑新陈代谢的个体差异。 研究对象将从之前的研究中已经测试过对新奇事物的反应的动物中选择。 因此，我们将能够选择一些对新奇事物具有高度反应性的动物，以及其他行为更稳定且反应性较低的动物。 这将使我们能够确定哪些大脑区域在应对这种运输挑战时表现出最大的代谢活动差异，以及哪些大脑区域在挑战期间的代谢激活与对新奇事物的行为反应之间表现出很强的相关性。