SHORT TERM NEG & POS FEEDBACK EFFECTS OF GONADAL STEROIDS PET SCANNING

短期负面

• 批准号: 7731232
• 负责人: JANET E HALL
• 金额: $ 0.29万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731232
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Dose; End Point; Estradiol; Estrogens; Feedback; Funding; Gonadal Steroid Hormones; Grant; Infusion procedures; Institution; Pituitary Gland; Positron-Emission Tomography; Progesterone; Research; Research Personnel; Resources; Scanning; Source; United States National Institutes of Health; Woman; Women' s Group; age related; day; hypothalamic pituitary axis; time interval

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Study to investigate age-dependent estrogen feedback on the pituitary/hypothalamic axis using PET scanning. The main hypothesis is that effects will be greater in older than in younger women and that high dose gonadal steroids will have a greater pituitary effect and that this effect will be greater in older subjects. Two groups of women each 45-55 and 70-80 will be admitted to the GCRC for 5 days for graded estradiol and progesterone infusions. PET scanning will be done at timed intervals and will be the main endpoint.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 使用PET扫描研究年龄依赖性雌激素对垂体/下丘脑轴的反馈。 主要假设是老年女性的作用大于年轻女性，高剂量性腺类固醇对垂体的作用更大，这种作用在老年受试者中更大。 两组妇女，每组45-55岁和70-80岁，将进入GCRC接受5天的分级雌二醇和孕酮输注。 PET扫描将以定时间隔进行，并将作为主要终点。