PULSATILE GNRH IN ANOVULATORY INFERTILITY - 7 DAY STUDY (SEE SPID 0063)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 脉冲式GnRH通过程控便携式输注泵输送给低促性腺激素性性腺功能减退症患者。GnRH的剂量是基于先前的研究，这些研究表明75 ng/kg的剂量通常与单个卵泡发育和排卵以及正常的激素动力学相关。7天的脉冲式GnRH治疗足以启动垂体，并将使我们能够确定正常与异常反应，以及受试者是否有垂体成分导致其疾病或是否纯粹是下丘脑。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pulsatile GnRH is delivered via a programmed portable infusion pump to patients with hypogonadotropic hypogonadism. The dose of GnRH is based on previous studies which indicate that a dose of 75 ng/kg is generally associated with single follicle development and ovulation and normal hormonal dynamics. Seven days of pulsatile GnRH treatment is adequate for priming of the pituitary and will allow us to determine normal vs abnormal responses and whether subjects have a pituitary component to their disorder or whether it is purely hypothalamic.