PULSATILE GNRH IN ANOVULATORY INFERTILITY - 7 DAY STUDY (SEE SPID 0063)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 搏动性促性腺激素释放激素通过程序化便携式输液泵输送给性腺激素减退症患者。GnRH的剂量是基于先前的研究，这些研究表明，75 ng/kg的剂量通常与单个卵泡的发育、排卵和正常的激素动态有关。七天的脉冲式促性腺激素释放激素治疗足以启动垂体，并将使我们能够确定正常与异常反应，以及受试者的疾病是否与垂体有关，或者是否纯粹是下丘脑。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pulsatile GnRH is delivered via a programmed portable infusion pump to patients with hypogonadotropic hypogonadism. The dose of GnRH is based on previous studies which indicate that a dose of 75 ng/kg is generally associated with single follicle development and ovulation and normal hormonal dynamics. Seven days of pulsatile GnRH treatment is adequate for priming of the pituitary and will allow us to determine normal vs abnormal responses and whether subjects have a pituitary component to their disorder or whether it is purely hypothalamic.