VASCULAR ENDOTHELIAL CELL BIOPSY TO ASSESS ENDOTHELIAL CELL ACTIVATION IN PAT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 高胰岛素血症与通过功能评估(血流介导的扩张)和体内内皮细胞激活增强的血管反应性异常有关。 1.体内胰岛素抵抗程度与血管内皮细胞激活的关系 2.通过对心导管插入术和介入放射学过程中从导丝获得的血管内皮细胞的分子分析，证明肱动脉血流介导的扩张受损与内皮细胞激活增强之间的关系。 3.检验高胰岛素血症患者存在血管反应性异常(血流介导的扩张，FMD)的假设

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hyperinsulinemia is associated with abnormalities in vascular reactivity by functional assessment (flow mediated dilatation) and enhanced endothelial cell activation in-vivo. 1. To demonstrate an association between degree of insulin resistance and endothelial cell activation in-vivo 2. To demonstrate an association with impaired brachial artery flow mediated dilitation with enhanced endothelial cell activation by molecular analysis of vascular endothelial cells obtained from guide wires during cardiac catheterization and interventional radiology procedures 3. To test the hypothesis that abnormalities in vascular reactivity (flow mediated dilatation, fmd) are present in subjects with hyperinsulinemia