VASCULAR ENDOTHELIAL CELL BIOPSY TO ASSESS ENDOTHELIAL CELL ACTIVATION IN PAT

血管内皮细胞活检评估 PAT 中的内皮细胞激活情况

• 批准号: 7717056
• 负责人: ALPHA Alsbury FOWLER
• 金额: $ 0.04万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717056
• 关键词: Biopsy; Blood Vessels; Cardiac Catheterization Procedures; Computer Retrieval of Information on Scientific Projects Database; Dilatation - action; Endothelial Cells; Funding; Grant; Hyperinsulinism; Institution; Insulin Resistance; Interventional radiology; Mediating; Molecular Analysis; Pathological Dilatation; Procedures; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Vascular Endothelial Cell; brachial artery; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hyperinsulinemia is associated with abnormalities in vascular reactivity by functional assessment (flow mediated dilatation) and enhanced endothelial cell activation in-vivo. 1. To demonstrate an association between degree of insulin resistance and endothelial cell activation in-vivo 2. To demonstrate an association with impaired brachial artery flow mediated dilitation with enhanced endothelial cell activation by molecular analysis of vascular endothelial cells obtained from guide wires during cardiac catheterization and interventional radiology procedures 3. To test the hypothesis that abnormalities in vascular reactivity (flow mediated dilatation, fmd) are present in subjects with hyperinsulinemia

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 高胰岛素血症与通过功能评估（流动介导的扩张）和体内增强的内皮细胞活化的血管反应性异常有关。 1。证明胰岛素抵抗程度与体内内皮细胞活化之间的关联 2。通过通过在心脏导管和介入放射程序期间从导管中获得的血管内皮细胞的分子分析来证明与内皮细胞激活增强的臂动脉流介导的膨胀的关联，并增强内皮细胞的激活。 3。为了测试以下假设，即血管反应性异常（流动介导的扩张，FMD）存在于患有高胰岛素血症的受试者中