CLINICAL TRIAL: FAT REDISTRIBUTION AND METABOLIC CHANGE IN HIV INFECTION: PROTOC

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对主要目标的分析将需要多变量方法来同时根据几个预测因素来模拟内膜-中层厚度(IMT)。 主要目标： 为了测量第4-5年重新分布和代谢范围(FRAM)研究中的颈动脉内膜厚度，并比较HIV阳性受试者与CARDIA和MESA队列中的对照组受试者的结果，并对年龄、性别、种族和吸烟等HIV非独立危险因素进行了调整。 确定IMT与传统危险因素(血脂)的相关性 代谢、糖耐量、脂肪分布、吸烟、身体状况 活动度和血压)和促动脉粥样硬化性炎症 标记物[C-反应蛋白(CRP)、PAI-1、纤维蛋白原、IL-6和 干扰素α]在肥胖的FRAM参与者中测量的样本来自 第1-2年的首次FRAM研究访问和第4-5年的后续访问。 为了确定观察到的动脉粥样硬化增加的比例 可归因于传统危险因素、新的心血管疾病危险因素和艾滋病毒感染的艾滋病毒，以此作为确定未来干预进一步调查的目标的手段。 确定IMT与单独使用抗逆转录病毒(ARV)药物(即特定药物、药物类别)和联合使用的相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Analyses of the primary aims will require multivariate methods to model intima-media thickness (IMT) in terms of several predictors simultaneously. Primary aims: To measure carotid IMT in years 4-5 of redistribution and metabolic range (FRAM) study and compare results in HIV+ subjects to control subjects from the CARDIA and MESA cohorts with adjustment for HIV-independent risk factors, such as age, sex, race, and smoking. To determine the association of IMT with traditional risk factors (lipid metabolism, glucose tolerance, fat distribution, smoking, physical activity and blood pressure) and with pro-atherosclerotic inflammatory markers [C-reactive protein (CRP), PAI-1, fibrinogen, IL-6, and interferon alpha] measured in fat FRAM participants in samples from the Yr 1-2 initial FRAM Study visit and at the Yr 4-5 follow-up visit. To determine the fraction of the increased atherosclerosis observed in HIV that can be attributed to traditional risk factors, novel cardiovascular disease (CVD) risk factors and HIV infection as a means for identifying targets for future intervention of further investigation. To determine the association of IMT with usage of antiretroviral (ARV) agents alone (i.e., specific drugs, classes of drugs) and in combination.