A5142 A PHASE III, OPEN-LABEL COMPARISON OF LOPINAVIR/RITONAVIR (AIDS)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A5142 is a phase III, randomized, three-arm, open-label study comparing the effectiveness of the following regimens for the initial treatment of HIV infection: Nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimen (efavirenz [EFV] plus stavudine extended release [d4T XR] (or zidovudine [ZDV]) plus lamivudine [3TC]) Ritonavir (RTV)-enhanced protease inhibitor (PI)-based regimen (lopinavir/ritonavir [LPV/r] plus d4T XR (or ZDV) plus 3TC). Nucleoside reverse transcriptase inhibitor (NRTI)-sparing regimen (EFV plus LPV/r).