RAPIDITY OF PROGESTERONE SUPPRESION OF LH PULSE FREQUENCY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. LH exhibits diurnal changes during puberty, with nocturnal increases in LH pulse frequency and amplitude. We hypothesize that these LH increases stimulate ovarian P and E2, which in turn suppresses LH pulsatility during the following day. For this hypothesis to be viable, these sex steroids would necessarily have acute actions, effecting GnRH pulse frequency changes over hours rather than days. The rapidity with which P supresses GnRH frequency is unknown. We propose to assess this further.