NON-INVASIVE MEASUREMENT OF MICROVASCULAR BLOOD FLOW DURING MILD EXTERNAL COM

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 我们的具体目标是： 测量健康受试者和慢性静脉功能不全（CVI）患者中轻度外部压迫引起的腿部肌肉血流量（MBF）和皮肤血流量（SBF）微循环增加。 在健康受试者和慢性静脉功能不全（CVI）患者中测量轻度外部压迫引起的腿部肌肉氧合变化。 优化连续压迫的压力，以在健康受试者和CVI患者中诱导最大微循环血流量。 优化间歇性气动压迫（IPC）的压迫压力、持续时间和频率，以在健康受试者和CVI患者中诱导最大微循环血流量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our specific aims are: To measure Muscle Blood Flow (MBF) and Skin Blood Flow (SBF) microcirculatory increases in the leg caused by mild external compression in healthy subjects and patients with Chronic Venous Insufficiency (CVI). To measure muscle oxygenation changes in the leg caused by mild external compression in healthy subjects and patients with Chronic Venous Insufficiency (CVI). To optimize pressures of Continuous Compression to induce maximum microcirculatory blood flow in healthy subjects and patients with CVI. To optimize compression pressures, duration, and frequency of Intermittent Pneumatic Compression (IPC) to induce maximum microcirculatory blood flow in healthy subjects and patients with CVI.