PRADER-WILLI SYNDROME AND EARLY-ONSET MORBID OBESITY NATURAL HISTORY CLINICAL PR

普瑞德威利综合征和早发性病态肥胖自然史临床公关

• 批准号: 7725048
• 负责人: VIRGINIA Eunice KIMONIS
• 金额: $ 0.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725048
• 关键词: Affect; Behavioral; Child; Childhood; Chromosomes; Clinical; Clinical Research; Complex; Computer Retrieval of Information on Scientific Projects Database; Data; Diagnostic; Disease; Endocrinology; Evaluation; Failure to Thrive; Funding; Future; Genes; Genetic; Genotype; Goals; Grant; Hyperphagia; Hypogonadism; Impaired cognition; Individual; Institution; Localized; Morbid Obesity; Muscle hypotonia; Mutation; Natural History; Neonatal; Numbers; Obesity; Personal Satisfaction; Phenotype; Population; Population Study; Prader-Willi Syndrome; Research; Research Personnel; Resources; Source; Syndrome; United States National Institutes of Health; early onset; neurobehavioral

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study, as a component of the NIH-sponsored Rare Diseasese Clinical Research Network (RDCRN), is to obtain detailed longitudinal natural history data on a large population of individuals affected by Prader-Willi syndrome (PWS) and, to a lesser extent, individuals who have Early Morbid Obesity (EMO) not due to PWS. The ultimate hope is that this well-studied population will provide data to be used in future for diagnostics, therapies and genotype-phenotype correlations for these two diseases. Prader-Willi syndrome (PWS) is a complex neurobehavioral syndrome whose main clinical features include obesity, hyperphagia, hypotonia, cognitive impairment, a distinct behavioral phenotype, hypogonadism, and neonatal failure-to-thrive. The genetic defect has been localized to a 2 megabase region of chromosome 15q11-q13. It is a contiguous gene syndrome with the loss of expression of several genes resulting in the complete phenotype. As PWS is the most common recognized genetic cause of morbid obesity, a growing number of morbidly obese children are being referred to pediatric genetics and pediatric endocrinology for evaluation of PWS. Many of these children clinically and molecularly do not have PWS. We refer to these individuals as the Early Morbid Obesity (EMO) population.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 作为NIH赞助的罕见病临床研究网络（RDCRN）的一个组成部分，本研究的目标是获得大量受Prader-Willi综合征（PWS）影响的个体的详细纵向自然史数据，以及在较小程度上，患有早期病态肥胖（EMO）的个体不是由于PWS。最终的希望是，这个经过充分研究的人群将提供数据，用于未来这两种疾病的诊断，治疗和基因型-表型相关性。 Prader-Willi综合征（PWS）是一种复杂的神经行为综合征，其主要临床特征包括肥胖、摄食过多、张力减退、认知障碍、独特的行为表型、性腺功能减退和新生儿发育不良。遗传缺陷已定位于染色体15 q11-q13的2兆碱基区域。 它是一种连续基因综合征，几个基因的表达缺失导致完整的表型。由于PWS是最常见的公认的病态肥胖的遗传原因，越来越多的病态肥胖儿童被称为儿科遗传学和儿科内分泌学评估PWS。 这些儿童中的许多在临床上和分子上没有PWS。 我们将这些人称为早期病态肥胖（EMO）人群。