SERUM SELENIUM LEVELS AND THYROID CANCER DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究旨在确定血清和组织中的硒浓度与甲状腺癌诊断之间是否存在关联，如果是，这种关联是否具有性别特异性。这项研究是一项横断面、病例对照的试点项目，旨在从一个中心收集为期一年的数据。目标有四个方面。第一个是确定在过去10年内患上甲状腺癌的患者的血清硒水平是否低于对照组。第二个目标是确定甲状腺癌诊断和血清硒水平之间的任何关系是否受患者性别的影响。第三个目标是确定与对照组相比，被诊断为甲状腺癌的患者的甲状腺组织硒水平是否较低。最终目标是确定患者性别是否影响甲状腺癌的存在和组织硒水平之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to determine whether there is an association between serum and tissue concentrations of selenium and the diagnosis of thyroid cancer, and if so, whether the association is gender-specific. The study is a cross-sectional, case-controlled pilot project designed to collect data over a one-year period form a single center. The objectives are four-fold. The first is to determine whether serum selenium levels are lower in patients who developed thyroid cancer within the preceding 10 years, compared with controls. The second objective is to determine whether any relationship between a thyroid cancer diagnosis and serum selenium levels is affects by patient gender. The third objective is to determine whether tissue selenium levels are lower in the thyroid glands of patients with a diagnosis of thyroid cancer, compared with controls. The final objective is to determine whether any relationship between the presence of thyroid cancer and tissue selenium levels is affected by patient gender.