SERUM SELENIUM LEVELS AND THYROID CANCER DEVELOPMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究旨在确定血清和组织中硒浓度与甲状腺癌诊断之间是否存在关联，如果是，这种关联是否具有性别特异性。本研究是一项横断面、病例对照的试点项目，旨在从一个中心收集一年以上的数据。目标有四个方面。首先是确定与对照组相比，在过去10年内患甲状腺癌的患者的血清硒水平是否较低。第二个目的是确定甲状腺癌诊断和血清硒水平之间的任何关系是否受患者性别的影响。第三个目的是确定与对照组相比，诊断为甲状腺癌的患者的甲状腺组织硒水平是否较低。最终目的是确定甲状腺癌的存在和组织硒水平之间的任何关系是否受到患者性别的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to determine whether there is an association between serum and tissue concentrations of selenium and the diagnosis of thyroid cancer, and if so, whether the association is gender-specific. The study is a cross-sectional, case-controlled pilot project designed to collect data over a one-year period form a single center. The objectives are four-fold. The first is to determine whether serum selenium levels are lower in patients who developed thyroid cancer within the preceding 10 years, compared with controls. The second objective is to determine whether any relationship between a thyroid cancer diagnosis and serum selenium levels is affects by patient gender. The third objective is to determine whether tissue selenium levels are lower in the thyroid glands of patients with a diagnosis of thyroid cancer, compared with controls. The final objective is to determine whether any relationship between the presence of thyroid cancer and tissue selenium levels is affected by patient gender.