IDENTIFICATION OF LEUKOCYTE GENES THAT ARE REGULATED BY THYROID HORMONE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标2涉及与儿童国家医学中心的Eric霍夫曼博士合作，鉴定一组白细胞基因，其表达水平被甲状腺激素改变。正在研究两种特定细胞类型中的基因表达：单核细胞和CD 8细胞。此外，除了微阵列分析外，我们还计划在本研究中招募的甲状腺功能减退和甲状腺功能亢进受试者中进行检测蛋白质组学。14例甲状腺功能减退受试者入组并完成了研究。1例甲状腺功能亢进受试者入组该受试者，但不幸的是在完成方案前失访。计划入组20例甲状腺功能减退和20例甲状腺功能亢进受试者，共计40例受试者

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aim 2 involves identifying a panel of leukocyte genes whose level of expression is altered by thyroid hormone in collaboration with Dr. Eric Hoffman from Children's National Medical Center. Gene expression in two specific cell types: monocytes and CD8 cells is being examined. In addition, we are also planning to perform detection proteomics, in addition to microarray analyses, in the hypothyroid and hyperthyroid subjects enrolled in this study. 14 hypothyroid subjects have been enrolled in and completed the study. One hyperthyroid subject was enrolled in the subject, but unfortunately was lost to follow-up before he completed the protocol. The planned enrollment is 20 hypothyroid and 20 hyperthyroid subjects for a total of 40 subjects