PULMONARY HYPERTENSION AND THE HYPOXIC RESPONSE IN SICKLE CELL DIESEASE:

镰状细胞病的肺动脉高压和缺氧反应：

• 批准号: 7717195
• 负责人: CATERINA Patrizia MINNITI
• 金额: $ 4.31万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717195
• 关键词: Adolescent; Blood Vessels; Candidate Disease Gene; Child; Computer Retrieval of Information on Scientific Projects Database; Funding; Genetic Polymorphism; Grant; Hematological Disease; Hypoxia; Hypoxia Inducible Factor; Institution; Mediating; Pathogenesis; Pathologic; Patients; Polycythemia; Prevalence; Pulmonary Hypertension; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Sickle Cell; Sickle Cell Anemia; Source; United States National Institutes of Health; design; genotyping technology; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The research is designed to determine the prevalence and risk factors of pulmonary hypertension in children and adolescents with sickle cell disease, and to determine the role of hypoxic response in its pathogenesis. In this regard, proliferative vascular responses mediated by i)hypoxia inducible factor (HIF)- with Chuvash polycythemia (CP), another hematological disorder characterized by increased risk for PHT. High throughput microarray and genotyping technologies will be employed to identify candidate gene polymorphisms involved in pathologic responses to hypoxia in SCD and CP patients with and without PHT.

这个子项目是众多研究子项目之一