Innovations in Pediatric Pain Research

描述（申请人提供）：这项申请的具体目的是：1）使用创新技术改善功能结局的测量，并为患有慢性疼痛的青少年提供心理干预，和2）为候选人提供必要的受保护的时间和资源，以指导正在进行临床研究的博士后研究员和初级教员，小儿疼痛候选人的计划研究重点是开发创新方法来评估和治疗慢性疼痛，残疾和睡眠问题。在该奖项的过程中，候选人将使用创新技术完成研究，以改善睡眠-觉醒行为的新型纵向研究中的疼痛和睡眠测量。她将开展新的研究，以检查互联网家庭认知行为干预对改善慢性疼痛青少年功能结果的有效性。候选人有一个既定的跟踪记录，提供指导研究生，博士后研究员，和初级教师在心理学和医学。该奖项分配的时间增加将使候选人有机会专注于培训更多的博士后研究员和教师。该研究计划包括两个项目：NIH/NICHD RO 1“慢性疼痛青少年的睡眠-觉醒障碍”，以及一项新的临床试验，即互联网提供的慢性疼痛心理治疗“基于网络的CBT对慢性疼痛青少年客观功能结果的影响”。“指导计划开始临床研究者包括监督参与候选人的正在进行的研究;进行独立研究;和经验，在专业活动和实现专业的里程碑。通过俄勒冈州健康与科学大学（OHSU）的人类调查项目，一个NIH K30项目，向学员提供正式的教学计划，包括研究设计研讨会，随机对照试验，伦理/人类受试者，赠款写作和先进的分析方法。OHSU为该奖项提供了理想的环境，因为建立了合作，致力于以患者为导向的研究，以及强大的临床转化研究中心的存在。相关性（参见说明）：候选人研究计划的公共卫生目标是为患有慢性疼痛和睡眠问题的青少年开发创新治疗方法，以提高目前的护理标准，并最大限度地减少疼痛和残疾的长期问题。此外，候选人还寻求培养这一领域的下一代以患者为导向的研究人员。

DESCRIPTION (provided by applicant): The Specific Aims of this application for a Midcareer Investigator Award in Patient-Oriented Research are 1) to use innovative technologies to Improve measurement of functional outcomes and to deliver psychological interventions to youth with chronic pain, and 2) to provide the candidate protected time and resources necessary to mentor postdoctoral fellows and junior faculty members who are pursuing clinical Investigation in pediatric pain. The candidate's programmatic research has focused on developing innovative methods to assess and treat chronic pain, disability, and sleep problems. During the course of this award, the candidate will complete research studies using innovative technologies to improve measurement of pain and sleep in a novel longitudinal study of sleep-wake behaviors. She will develop new research to examine the efficacy of an internet family cognitive-behavioral intervention on improving functional outcomes in adolescents with chronic pain. The candidate has an established track record of providing mentorship to graduate students, postdoctoral fellows, and junior faculty in psychology and medicine. The increased time allotted by this award will give the candidate the opportunity to focus on training additional postdoctoral fellows and faculty. The Research Plan includes two projects: an NIH/NICHD RO1 "Sleep-wake disturbances in adolescents with chronic pain," and a new clinical trial of an internet delivered psychological treatment for chronic pain "Effect of Web-based CBT on Objective Functional Outcomes in Youth with Chronic Pain." The Mentoring Plan for beginning clinical Investigators consists of supervised participation in the candidate's ongoing research; conduct of independent research; and experience in professional activities and achieving professional milestones. A formal didactic program is available to mentees through the Human Investigations Program at Oregon Health & Science University (OHSU), a NIH K30 program, with seminars on study design, randomized controlled trials, ethics/human subjects, grant writing, and advanced analytic approaches. OHSU provides an ideal setting for this award because of the established collaborations, commitment to patient-oriented research, and the presence of a strong Clinical Translational Research Center. RELEVANCE (See instructions): The public health goals of the candidate's research program are to develop innovative treatments for youth with chronic pain and sleep problems that can improve the current standard of care and minimize long-term problems with pain and disability. In addition, the candidate seeks to train the next generation of patient-oriented researchers in this area.