Functional Magnetic Resonance Imaging Markers of Early-Onset Suicide Attempt

早发自杀未遂的功能磁共振成像标志物

• 批准号: 7586923
• 负责人: LISA PAN
• 金额: $ 15.49万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-13 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7586923
• 关键词: Adolescent; Affective; Age; Aggressive behavior; Amygdaloid structure; Anger; Anxiety; Area; Cessation of life; Child; Child Development; Childhood; Clinical Research; Cognitive; Corpus striatum structure; Data Analyses; Decision Making; Doctor of Medicine; Dorsal; Emotional; Emotions; Face; Facial Expression; Feeling suicidal; Functional Magnetic Resonance Imaging; Future; Gambling; Gender; Impulsivity; Individual; Instruction; Investigation; Iowa; Label; Measures; Mentors; Methods; Modification; Monitor; Neurobiology; Neurocognitive; Neurosciences; Neurosciences Research; Outcome; Patient Self-Report; Pattern; Performance; Population; Prefrontal Cortex; Prevention; Process; Psychiatrist; Recording of previous events; Recruitment Activity; Relative (related person); Research; Research Project Grants; Research Training; Suicide; Suicide attempt; Suicide prevention; Symptoms; Task Performances; Training; Ventral Striatum; career; cognitive control; cognitive neuroscience; depression; design; early onset; improved; multidisciplinary; neural circuit; neural patterning; neuroimaging; prevent; programs; public health relevance; relating to nervous system; response; suicidal behavior; suicidal risk

DESCRIPTION (provided by applicant): The proposed application will provide the candidate with the needed expertise to establish an independent research career focusing on the investigation of the neurobiology suicide attempt in children and adolescents. The applicant is a child and adolescent psychiatrist who proposes to obtain multidisciplinary training from mentors in suicidology and functional neuroimaging, with a panel of experts in childhood neurobiology, child development, neuroimaging, and data analysis. We propose to use established methods in functional neuroimaging and neuroscience to characterize the neurobiology underlying early onset suicide attempt. We will assess these adolescents, and age-matched psychiatric controls and healthy controls with well-established neurocognitive tasks. We hypothesize that history of suicide attempt in adolescents will be associated with differences in patterns of neural activity compared with both psychiatric and healthy controls. The primary objective of this research project is to examine the neural circuitry underlying traitdependent abnormalities in cognitive and emotion processing in adolescents with depression with and without history of suicide attempt, by focusing on the following areas: emotional processing, cognitive control, and risky decision-making, that have been demonstrated to recruit ventral and dorsomedial prefrontal cortices and amygdala and ventral striatum, dorsal prefrontal cortical regions, and ventromedial and dorsomedial prefrontal cortices, respectively. Our study of the neural circuitry of adolescent suicide attempt is important in that it will help to more precisely define: 1) cognitive and affective processing abnormalities associated with suicidal behavior; 2) functional neurocircuitry related to these neurocognitive abnormalities; and, in turn, 3) the relationship between these abnormalities and onset and history of suicidal behavior. Increased understanding of these neural markers will have a significant impact upon the future targeting of treatment and prevention efforts to improve the long-term outcome of individuals with suicidal behavior. This is the first study of its kind in a pediatric population. The functional neuroimaging instruction, didactics, coursework, and clinical research training, sponsored by Mary Phillips, M.D., M.D. (Cantab), Director of the Functional Neuroimaging Program, and David Brent, M.D., Endowed Chair in Suicide Studies, will prepare the candidate to perform multidisciplinary cognitive neuroscience research in adolescent suicide prevention. PUBLIC HEALTH RELEVANCE: Identification of markers for suicide risk and increased understanding of the cognitive neuroscience of suicide attempt may have a significant impact upon the future design and monitoring of treatment and prevention efforts to prevent death and improve the long-term outcome of individuals with suicidal behavior. This is the first study of its kind in adolescents.

描述（由申请人提供）：拟议的申请将为候选人提供所需的专业知识，以建立独立的研究生涯，重点调查儿童和青少年的神经生物学自杀企图。申请人是一名儿童和青少年精神病学家，他提议从自杀学和功能神经影像学导师那里获得多学科培训，并由儿童神经生物学、儿童发展、神经影像学和数据分析方面的专家小组组成。我们建议使用功能神经影像学和神经科学中的既定方法来描述早期自杀企图背后的神经生物学特征。我们将通过完善的神经认知任务来评估这些青少年、年龄匹配的精神病对照和健康对照。我们假设，与精神病学和健康对照相比，青少年的自杀企图史与神经活动模式的差异有关。该研究项目的主要目标是检查性状依赖的神经回路 有或没有自杀企图史的抑郁症青少年的认知和情绪处理异常，重点关注以下领域：情绪处理、认知控制和风险决策，这些领域已被证明可以募集腹侧和背内侧前额皮质、杏仁核和腹侧纹状体、背侧前额皮质区域以及腹内侧和背内侧 分别是前额皮质。我们对青少年自杀企图的神经回路的研究很重要，因为它将有助于更精确地定义：1）与自杀行为相关的认知和情感处理异常； 2）与这些神经认知异常相关的功能性神经回路； 3) 这些异常与自杀行为的发生和历史之间的关系。增加对这些神经标志物的了解将对未来治疗和预防工作的目标产生重大影响，以改善有自杀行为的个体的长期结果。 这是针对儿科人群的首次此类研究。功能神经影像学指导、教学、课程作业和临床研究培训由功能神经影像项目主任 Mary Phillips 医学博士（坎塔布）和自杀研究特聘主席 David Brent 医学博士赞助，将为候选人在青少年自杀预防方面进行多学科认知神经科学研究做好准备。 公共卫生相关性： 识别自杀风险标记并加深对自杀认知神经科学的理解 自杀未遂可能会对未来治疗的设计和监测产生重大影响 旨在预防死亡并改善有自杀行为的个人的长期结果的预防工作。 这是第一项针对青少年的此类研究。