Discovery of Functionally Relevant Imaging Biomarkers in Multiple Sclerosis

多发性硬化症功能相关成像生物标志物的发现

• 批准号: 7569747
• 负责人: Daniel Salo Reich
• 金额: $ 7.61万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2009-09-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7569747
• 关键词: Affect; Animal Experimentation; Anus; Attention; Award; Biological Markers; Brain; Budgets; Chronic Disease; Clinic; Clinical; Clinical Data; Clinical Trials; Clinical/Radiologic; Cognition; Collection; Communities; Complex; Data; Data Set; Databases; Deltastab; Detection; Development; Diagnostic; Diagnostic radiologic examination; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Doctor of Philosophy; Early treatment; Education; Emotions; Environment; Equipment; Esthesia; Faculty; Fellowship; Frequencies; Functional disorder; Funding; Future; Goals; Grant; Image; Imaging Techniques; Individual; Inflammatory; Laboratories; Lead; Length; Link; Magnetic Resonance Imaging; Manuals; Maps; Mathematics; Measurement; Measures; Mentors; Methods; Modeling; Monitor; Movement; Multimodal Imaging; Multiple Sclerosis; Natural History; Nerve Degeneration; Nerve Fibers; Neuraxis; Neurologic; Neurology; Normalcy; Optic Chiasm; Optic Nerve; Optic tract structure; Optical Coherence Tomography; Optics; Outcome Measure; Pathology; Pathway interactions; Patient Care; Patients; Pharmaceutical Preparations; Phase; Physicians; Physics; Physiologic pulse; Positioning Attribute; Predictive Value; Probability; Property; Publishing; Regression Analysis; Relaxation; Research; Research Personnel; Research Proposals; Residencies; Retina; Sample Size; Scanning; Sclerosis; Staging; Statistical Data Interpretation; Statistical Methods; Structure; System; Techniques; Testing; Time; Training; Universities; Validation; Vision; Visual; Visual Acuity; Visual Pathways; Visual system structure; Wages; Water; Weight; Woman; Work; base; carvedilol; cerebral atrophy; clinical care; clinical practice; cohort; design; disability; extrastriate; gray matter; imaging modality; improved; innovation; neurophysiology; neuroprotection; prevent; programs; public health relevance; research study; response; retinal nerve fiber layer; skills; tool; trend; validation studies; white matter; young adult

DESCRIPTION (provided by applicant): This proposal focuses on magnetic resonance imaging (MRI) in multiple sclerosis (MS), a chronic disease of the central nervous system that is the most common cause of non-traumatic neurologic disability in young adults and that causes dramatic abnormalities on MRI scans. To study the progression of MS, I will use new MRI techniques, particularly diffusion tensor imaging, to study the links between clinical dysfunction - especially in the visual system - and imaging abnormalities. My hypothesis is that quantitative and functionally relevant measures will substantially improve our ability to monitor MS over time and will therefore be directly applicable to routine patient care and as imaging-based biomarkers for clinical trials of new MS therapies. Proving this hypothesis will require careful acquisition of serial MRI and clinical data from a large cohort of MS patients, together with development of new imaging sequences and innovative analysis of their results. Johns Hopkins University, where I will carry out the mentored portion of the award, offers a particularly rich environment for this research. In addition, my background ideally positions me to carry out this proposal: I am near the end of a seven-year combined residency-fellowship in neurology, diagnostic radiology, and neuroradiology; I completed a Ph.D. in experimental and quantitative systems neurophysiology (including animal experimentation); and I received my undergraduate education in mathematics and physics. With this combination of clinical, laboratory, and quantitative skills, I will develop new imaging methods and refine them into powerful tools to provide crucial information for clinicians working at the patient's bedside. Public Health Relevance: There is both an urgent need and a promising opportunity to develop automated, quantitative methods that are functionally relevant, that are straightforward to use in routine clinical practice, and that can sensitively assess disease progression in multiple sclerosis as well as response to therapy. The proposed research is directed toward this goal, investigating the links between imaging abnormalities and clinical disability, especially in the visual system, and identifying markers for use in clinical care and future drug trials.

描述（由申请人提供）：该提案侧重于多发性硬化症（MS）的磁共振成像（MRI），多发性硬化症是一种慢性中枢神经系统疾病，是年轻人非创伤性神经功能障碍的最常见原因，并导致MRI扫描出现显著异常。为了研究MS的进展，我将使用新的MRI技术，特别是扩散张量成像，来研究临床功能障碍（特别是视觉系统）和成像异常之间的联系。我的假设是，随着时间的推移，定量和功能相关的措施将大大提高我们监测MS的能力，因此将直接适用于常规患者护理，并作为新MS疗法临床试验的基于成像的生物标志物。要证明这一假设，需要仔细采集大量MS患者的系列MRI和临床数据，同时开发新的成像序列并对其结果进行创新分析。约翰霍普金斯大学，我将在那里进行该奖项的指导部分，为这项研究提供了一个特别丰富的环境。此外，我的背景使我能够理想地完成这项提议：我即将结束为期七年的神经病学、诊断放射学和神经放射学的住院实习;我完成了博士学位。在实验和定量系统神经生理学（包括动物实验），我接受了我的本科教育，数学和物理学。有了临床，实验室和定量技能的结合，我将开发新的成像方法，并将其改进为强大的工具，为在患者床边工作的临床医生提供关键信息。 公共卫生相关性：有迫切的需要和一个充满希望的机会，开发自动化，定量的方法是功能相关的，这是直接使用在常规的临床实践中，可以敏感地评估疾病进展多发性硬化症以及治疗反应。拟议的研究是针对这一目标，调查成像异常和临床残疾之间的联系，特别是在视觉系统中，并确定用于临床护理和未来药物试验的标志物。