DIETS FOR DYSLIPIDEMIA IN THE METABOLIC SYNDROME

代谢综合征血脂异常的饮食

• 批准号: 7603508
• 负责人: ROBERT KNOPP
• 金额: $ 0.21万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603508
• 关键词: Apoprotein (B); Blood Vessels; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Consensus; Coronary heart disease; Counseling; Diet; Dietary Fats; Drops; Dyslipidemias; Fat-Restricted Diet; Fatty acid glycerol esters; Food; Funding; Glucose; Grant; High Density Lipoproteins; Hypertriglyceridemia; Inflammatory; Institution; Insulin; Insulin Resistance; Intake; Lipids; Lipoproteins; Low-Density Lipoproteins; Measures; Mediating; Metabolic; Metabolic syndrome; Observational Study; Overweight; Persons; Proteins; Randomized; Rate; Research; Research Design; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Week; Weight; Woman; adiponectin; base; brachial artery; cytokine; feeding; men; saturated fat

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Two defining features of the metabolic syndrome (MetS) are high triglycerides (TG) and low HDL (dyslipidemia of MetS). At weight stability, there is no consensus on the dietary fat and carbohydrate proportions best suited for managing the dyslipidemia and the impaired vascular reactivity of MetS. In contrast to extreme high and low-fat diets, diets moderate in fat and carbohydrate intake may be more beneficial in MetS based on recent studies. Overweight and insulin resistant persons appear to be less responsive to saturated fat restriction than normal weight persons. Consistent with these findings are lower rates of coronary disease in persons ingesting higher fat diets in observational studies. This study will compare lipoprotein and vascular effects of two diets in a randomized, 4-week, crossover, feeding study design, using food prepared in the metabolic kitchen of the UW GCRC. Diets will contain 40% fat, 45% carbohydrate or 20% fat, 65% carbohydrate with equivalent protein (15%) and saturated fat (8%). Weight will remain stable. Seventy-two men and women will be randomized to yield a minimum of 60 finished subjects at a 20% drop out rate. Weight and other vital signs are measured twice weekly when food is picked-up from the GCRC. Lipoprotein lipids are measured at 0, 3 and 4 weeks. Apoproteins B and A-I, LDL buoyancy, glucose, insulin, adiponectin, inflammatory cytokines and flow-mediated brachial artery reactivity are measured at 0 and 4 weeks. A 4-month extension will test the durability of the effect of the second diet assignment under dietician counseling.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 代谢综合征 (MetS) 的两个定义特征是高甘油三酯 (TG) 和低 HDL（MetS 血脂异常）。在体重稳定方面，对于最适合控制血脂异常和 MetS 血管反应性受损的膳食脂肪和碳水化合物比例尚未达成共识。 根据最近的研究，与极高和低脂肪饮食相比，适度摄入脂肪和碳水化合物的饮食可能对 MetS 更有益。超重和胰岛素抵抗的人似乎对饱和脂肪限制的反应不如正常体重的人。与这些发现一致的是，观察性研究中摄入高脂肪饮食的人患冠心病的几率较低。 这项研究将在随机、为期 4 周的交叉喂养研究设计中，使用 UW GCRC 代谢厨房准备的食物，比较两种饮食的脂蛋白和血管影响。饮食将含有 40% 脂肪、45% 碳水化合物或 20% 脂肪、65% 碳水化合物以及同等蛋白质 (15%) 和饱和脂肪 (8%)。 体重将保持稳定。 72 名男性和女性将被随机分配，以 20% 的退出率选出至少 60 名完成的受试者。 当从 GCRC 取食物时，每周测量两次体重和其他生命体征。在第 0、3 和 4 周时测量脂蛋白脂质。在第 0 周和第 4 周测量脱辅基蛋白 B 和 A-I、LDL 浮力、葡萄糖、胰岛素、脂联素、炎性细胞因子和血流介导的肱动脉反应性。延长 4 个月将测试在营养师咨询下第二次饮食分配效果的持久性。