DIETS FOR DYSLIPIDEMIA IN THE METABOLIC SYNDROME

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 代谢综合征(METS)的两个显著特征是高甘油三酯(TG)和低高密度脂蛋白(HDL值)。在体重稳定方面，对于最适合控制蛋氨酸的血脂异常和受损的血管反应性的饮食脂肪和碳水化合物比例，没有达成共识。 根据最近的研究，与极高脂肪和极低脂肪饮食相比，适度脂肪和碳水化合物摄入的饮食可能对蛋氨酸更有益。超重和胰岛素抵抗的人似乎比正常体重的人对饱和脂肪限制的反应更差。与这些发现一致的是，在观察性研究中，摄入高脂肪饮食的人患冠状动脉疾病的比率较低。 这项研究将采用随机、为期4周的交叉喂养研究设计，使用UW GCRC代谢厨房准备的食物，比较两种饮食对脂蛋白和血管的影响。饮食将含有40%的脂肪，45%的碳水化合物或20%的脂肪，65%的碳水化合物以及等量的蛋白质(15%)和饱和脂肪(8%)。体重将保持稳定。72名男性和女性将随机产生至少60名完成测试的受试者，辍学率为20%。体重和其他生命体征在从GCRC取食物时每周测量两次。分别于0周、3周、4周测定血脂。分别在0周和4周检测载脂蛋白B和A-I、低密度脂蛋白浮力、血糖、胰岛素、脂联素、炎性细胞因子和血流介导的肱动脉反应性。延长4个月将测试在营养师咨询下第二次饮食分配的效果的持久性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Two defining features of the metabolic syndrome (MetS) are high triglycerides (TG) and low HDL (dyslipidemia of MetS). At weight stability, there is no consensus on the dietary fat and carbohydrate proportions best suited for managing the dyslipidemia and the impaired vascular reactivity of MetS. In contrast to extreme high and low-fat diets, diets moderate in fat and carbohydrate intake may be more beneficial in MetS based on recent studies. Overweight and insulin resistant persons appear to be less responsive to saturated fat restriction than normal weight persons. Consistent with these findings are lower rates of coronary disease in persons ingesting higher fat diets in observational studies. This study will compare lipoprotein and vascular effects of two diets in a randomized, 4-week, crossover, feeding study design, using food prepared in the metabolic kitchen of the UW GCRC. Diets will contain 40% fat, 45% carbohydrate or 20% fat, 65% carbohydrate with equivalent protein (15%) and saturated fat (8%). Weight will remain stable. Seventy-two men and women will be randomized to yield a minimum of 60 finished subjects at a 20% drop out rate. Weight and other vital signs are measured twice weekly when food is picked-up from the GCRC. Lipoprotein lipids are measured at 0, 3 and 4 weeks. Apoproteins B and A-I, LDL buoyancy, glucose, insulin, adiponectin, inflammatory cytokines and flow-mediated brachial artery reactivity are measured at 0 and 4 weeks. A 4-month extension will test the durability of the effect of the second diet assignment under dietician counseling.