PROXIMAL TUBULAR SODIUM REABSORPTION IN AFRICAN-AMERICANS AND WHITES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Serious kidney disease resulting in kidney failure is much more common in African-Americans than Whites. High blood pressure and diabetes are the most important causes of kidney disease, but they alone do not explain the racial difference. We have proposed that differences in how kidneys handle salt (sodium) and water can affect the filtering units of the kidney and result in damage that ultimately causes kidney failure. This suggestion is based on our recent observation that African-Americans with normal blood pressure reclaim sodium at a critical site, known as the proximal tubule, more rapidly than Whites. In this proposal, we will characterize the regulation of proximal tubular sodium reabsorption and overall kidney sodium handling. We hypothesize that African-Americans will have measurable increases in factors that stimulate sodium reabsorption and decreases in mechanisms that inhibit reabsorption compared to Whites. The goal of these studies is to provide a better understanding of how tubular transport differences contribute to kidney failure, particularly in African-Americans. We anticipate that the proposed studies will lead to the development of a diagnostic test for identifying a predisposition to kidney failure and monitoring response to therapy.'