TRAINING IN MOLECULAR AND CELLULAR CARDIOLOGY

这份申请是为了一项新的心血管领域的培训资助。 密歇根大学理科专业。的长期目标是 该计划旨在培养博士后医学博士和博士后研究员 分子和细胞领域的独立基础研究 心血管科学。这是一个部门间的 包括研究兴趣和研究的跨部门计划 内务部20名教职员工的专业知识 医学、生物化学、人类遗传学、 微生物学/免疫学、病理学、药理学、生理学、 外科学与霍华德·休斯医学院 来自密歇根州。该计划的教员代表了一个 杰出的分子和细胞生物学家团队，他们 研究兴趣分为三个相关的心血管领域 研究领域：1)血管细胞基因表达的调控。 强调了解细胞的分子基础 增殖、血栓形成和炎症，导致血管 病理学；2)调控基因表达的分子机制 在正常发育过程中的心肌和骨骼肌中 3)心血管疾病的基因治疗 疾病。 这笔培训补助金是通过心血管系统管理的 内科研究中心。该计划 该项目由项目主任伊丽莎白·G·纳贝尔博士和Dr。 项目联席主任Seigo Izumo都成立了调查人员。 纳贝尔博士是心血管研究中心的主任，出云博士是 是心内科主任。培训计划是 由一个由高级官员组成的内部咨询委员会监督 密歇根大学的院士和领导者。 受训人员是医学博士、医学博士/博士或博士后科学家。 第一年有四个博士后名额，总共八个 请在2-5年内提供职位，以支持研究人员 心血管科学的全日制基础研究。每位实习生 将致力于2-3年的研究性培训。博士后 实习生将对基本知识有长期的职业兴趣 心血管科学。医学博士和医学博士/博士实习生将 完成了三年的内科住院医师培训， 以及两年的临床心脏病学专科培训 这是由密歇根大学医院全额资助的。医学博士。 学员参加研究生研究培训计划 课程，既定的三个月的入门实验室培训 该大学开设的分子和细胞生物学课程 密歇根医学院。培训计划的力度很大 致力于增加妇女人数和任职人数偏低 接受心血管培训的少数族裔个人 研究。研究训练设施包括 心血管研究中心与个人研究 位于加州大学的20名教官的实验室 密歇根医学中心MSRB III/MSRB II/MSRB I/MS I和II， 总面积29,847平方英尺英国《金融时报》5个连续的研究空间 建筑物。在完成培训计划后，学员将 被引导申请独立研究经费并进行 作为心血管科学的独立研究人员， 学术医学院。

This application is for a new training grant in cardiovascular science at the University of Michigan. The long term objective of this program is to train postdoctoral M.D. and Ph.D. fellows for independent basic research careers in molecular and cellular cardiovascular science. This is an interdivisional and interdepartmental program incorporating the research interests and expertise of 20 faculty members in the Departments of Internal Medicine, Biological Chemistry, Human Genetics, Microbiology/Immunology, Pathology, Pharmacology, Physiology, Surgery and the Howard Hughes Medical Institute at the University of Michigan. The faculty preceptors of the program represent an outstanding group of molecular and cellular biologists whose research interests are divided into three related cardiovascular areas: 1) the regulation of gene expression in vascular cells with emphasis on understanding the molecular basis of cellular proliferation, thrombosis and inflammation, leading to vascular pathology; 2) the molecular mechanisms regulating gene expression in cardiac and skeletal muscle during normal development and in pathophysiological states; and 3) gene therapy for cardiovascular diseases. This training grant is administered through the Cardiovascular Research Center in the Department o Internal Medicine. The program is directed by Dr. Elizabeth G. Nabel, Program Director, and Dr. Seigo Izumo, Program Co-Director, both established investigators. Dr. Nabel directs the Cardiovascular Research Center, and Dr. Izumo is the Chief of the Division of Cardiology. The Training Program is supervised by an Internal Advisory Committee comprised of senior academicians and leaders at the University of Michigan. Trainees are M.D., M.D./Ph.D, or Ph.D. postdoctoral scientists. Four postdoctoral slots in the first year and a total of eight slots in years 2-5 are requested to support fellows pursuing fulltime basic research in cardiovascular science. Each trainee will commit to 2-3 years to research training. Ph.D. postdoctoral trainees will have longterm career interests in basic cardiovascular sciences. M.D. and M.D./Ph.D. trainees will have completed three years of residency training in Internal Medicine, as well as two years of clinical cardiology subspecialty training which is fully funded by the University of Michigan Hospital. M.D. trainees participate in a Postgraduate Research Training Program Course, an established three month introductory laboratory training course in molecular and cellular biology offered by the University of Michigan Medical School. The training program is strongly committed to increasing the number of women and underrepresented minority individuals who receive training in cardiovascular research. Facilities for research training include the Cardiovascular Research Center and the individual research laboratories of the 20 preceptors located at the University of Michigan Medical Center in MSRB III/MSRB II/MSRB I/MS I and II, encompassing 29,847 sq. ft. of research space in 5 contiguous buildings. Upon completion of the training program, trainees are guided to apply for independent research funding and to pursue careers as independent investigators in cardiovascular sciences at academic medical schools.