Molecular mechanisms that help organise effective synaptic transmission.

帮助组织有效突触传递的分子机制。

• 批准号: nhmrc : 569680
• 负责人: A/Pr Peter Noakes
• 金额: $ 37.06万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-help-synaptic-transmission/81403
• 关键词: Molecular; mechanisms; help; organise; effective

This study will test the idea that adhesion molecules alpha4- and beta2-laminin are needed for proper development and function of motor nerve - muscle connections. This study will provide insights into how such molecules control effective nerve-muscle communication, in both health and disease. We also believe that our results will provide the basic knowledge needed for identifying pharmacological targets that could improve such connections, and to promote reconnections between nerve and muscle.

这项研究将测试粘附分子α 4-和β 2-层粘连蛋白是运动神经-肌肉连接正常发育和功能所必需的这一观点。这项研究将为这些分子如何在健康和疾病中控制有效的神经-肌肉通讯提供见解。我们还相信，我们的研究结果将提供识别可以改善这种连接的药理学靶点所需的基本知识，并促进神经和肌肉之间的重新连接。