Postsynaptic signalling systems that sustain the nerve-muscle synapse

神经肌肉接头(NMJ)是运动神经控制我们随意肌肉细胞的突触。这个项目将研究神经和肌肉之间的分子信号系统，以帮助保持健康的NMJ。正常的衰老涉及肌肉力量的逐渐下降，通常会导致老年人失去独立性。我们将使用一个老鼠模型来测试NMJ信号系统的故障是否会导致老年时力量的丧失。

Neuromuscular junctions (NMJ) are the synapses through which motor nerves control our voluntary muscle cells. This project will investigate the molecular signalling system between nerve and muscle that helps maintain healthy NMJs. Normal ageing involves a progressive decline in muscle strength, often leading to loss of independence in the elderly. We will use a mouse model to test whether a breakdown of the NMJ signalling system contributes to the loss of strength in old age.