PATHOGENESIS OF NON-INSULIN DEPENDENT DIABETES MELLITUS

非胰岛素依赖型糖尿病的发病机制

• 批准号: 7603896
• 负责人: Thomas A Buchanan
• 金额: $ 3.88万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603896
• 关键词: B-Lymphocytes; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Defect; Diabetes Mellitus; Funding; Gestational Diabetes; Glucose; Grant; Hispanics; Institution; Insulin; Insulin Resistance; Liver; Longitudinal Studies; Muscle; Non-Insulin-Dependent Diabetes Mellitus; Oral Contraceptives; Pancreas; Pathogenesis; Pregnancy; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Weight Gain; Woman; diabetes risk; glucose production; insulin secretion

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a longitudinal study of the pathogenesis of gestational and type 2 diabetes in Hispanic women with gestational diabetes. Main findings are (a)defects in insulin secretion and insulin action in liver and muscle in GDM during pregnancy (b) poor insulin secretion and high glucose levels predict diabetes within six months after pregnancy, (c) poor insulin secretion, high glucose levels and high basal glucose production predict diabetes 11-26 months after pregnancy, (d) oral contraceptives do not increase the risk of diabetes after GDM, (e) additional pregnancy and weight gain increase the risk of diabetes after GDM, (f) treatment of insulin resistance reduces the risk of diabetes and preserves pancreatic B-cell function.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项关于西班牙裔妊娠期糖尿病妇女妊娠期和2型糖尿病发病机制的纵向研究。主要发现是：（a）妊娠期GDM患者肝脏和肌肉中胰岛素分泌和胰岛素作用缺陷（B）妊娠后6个月内胰岛素分泌不足和高葡萄糖水平预测糖尿病，（c）妊娠后11-26个月胰岛素分泌不足、高葡萄糖水平和高基础葡萄糖产生预测糖尿病，（d）口服避孕药不会增加GDM后糖尿病的风险，（e）额外怀孕和体重增加增加GDM后糖尿病的风险，（f）胰岛素抵抗的治疗降低糖尿病的风险并保留胰腺B细胞功能。