PATHOGENESIS OF NON-INSULIN DEPENDENT DIABETES MELLITUS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项对患有妊娠期糖尿病的西班牙裔妇女的妊娠期和2型糖尿病发病机制的纵向研究。主要研究结果如下：(A)妊娠期糖尿病患者肝脏和肌肉中的胰岛素分泌和胰岛素作用存在缺陷(B)胰岛素分泌不足和高血糖水平预示着妊娠后6个月内发生糖尿病，(C)胰岛素分泌不良、高血糖水平和高基础血糖生成可预测妊娠11-26个月后的糖尿病，(D)口服避孕药不会增加妊娠期糖尿病后患糖尿病的风险，(E)额外怀孕和体重增加会增加妊娠期糖尿病后患糖尿病的风险，(F)治疗胰岛素抵抗可降低糖尿病风险，保护胰腺B细胞功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a longitudinal study of the pathogenesis of gestational and type 2 diabetes in Hispanic women with gestational diabetes. Main findings are (a)defects in insulin secretion and insulin action in liver and muscle in GDM during pregnancy (b) poor insulin secretion and high glucose levels predict diabetes within six months after pregnancy, (c) poor insulin secretion, high glucose levels and high basal glucose production predict diabetes 11-26 months after pregnancy, (d) oral contraceptives do not increase the risk of diabetes after GDM, (e) additional pregnancy and weight gain increase the risk of diabetes after GDM, (f) treatment of insulin resistance reduces the risk of diabetes and preserves pancreatic B-cell function.