CBT for Latinos with Generalized Anxiety Disorder in the General Medical Sector

描述（由申请人提供）：广泛性焦虑症是一种普遍的、慢性的、昂贵的心理健康问题，与功能下降、卫生服务利用率增加和随后共病性重度抑郁症的高风险相关。尽管有大量证据支持CBT治疗广泛性焦虑症的有效性，但拉美裔并没有从这些进步中获得同等的好处。在疗效和有效性研究中，讲西班牙语的拉丁美洲人通常被排除在外。为了解决这一差距，必须使讲西班牙语的拉丁美洲人获得干预措施临床发展的好处。本申请要求SCORE SC1进行一项随机对照研究，研究一种文化适应性的、基于cbt的人工干预广广性焦虑症，以获得其疗效的初步估计，并产生一个治疗效果大小的估计，这将为后续充分有力的随机对照试验的设计提供信息。该项目旨在为一项全面试验奠定基础，该试验将导致在讲西班牙语的拉丁美洲人，特别是波多黎各人中推进广泛性焦虑症的治疗。该奖项提供的支持将培养申请人的研究竞争力，以准备成功的R01资助申请，这将使她能够开发一个程序化的研究线，重点是为讲西班牙语的拉丁美洲人提供有效的焦虑和抑郁障碍治疗。在为期四年的职业发展计划中，申请人描述了长期目标和发展目标，为她在临床和转化研究领域开展高效的职业生涯做好准备。申请人的长期目标是成为R01水平的研究者，在治疗普遍的焦虑和抑郁症方面，建立一个程序化的研究路线，重点是为拉丁美洲人提供创新的基于证据的治疗方法，提高她的研究技能和能力，以指导和指导拉丁裔初级教师，并发展一个高产的临床和转化研究科学家的职业生涯。奖励期间的具体发展目标是：加强在设计和实施广泛性焦虑症干预研究方面的知识和经验，特别是基于认知行为治疗的干预；发展为广泛性焦虑症患者提供治疗的专门知识；加强与临床试验研究相关的先进统计技术应用方面的知识和技能；并提高拨款写作和手稿准备技能。

DESCRIPTION (provided by applicant): GAD is a prevalent, chronic, and costly mental-health problem associated with decreased functioning, increased health-service utilization, and high risk for subsequent comorbid major depression. Although significant evidence supports the effectiveness of CBT for the treatment of GAD, Latinos have not benefited equally from these advances. Spanish-speaking Latinos have been routinely excluded in both efficacy and effectiveness studies. To address this disparity, it is essential that the benefits of clinical developments in interventions be made available to Spanish-speaking Latinos. This application requests a SCORE SC1 to conduct a randomized, controlled study of a culturally adapted, manualized CBT-based intervention for GAD to obtain preliminary estimates of its efficacy and to generate a treatment effect size estimate that will inform the design of a subsequent adequately-powered randomized controlled trial. This project seeks to lay the foundation for a full trial that will lead to the advancement of treatments for GAD among Spanish-speaking Latinos, particularly Puerto Ricans. The support provided by this award will foster the research competitiveness of the applicant to prepare a successful R01 grant application that will allow her to develop a programmatic line of research focused on making available to Spanish-speaking Latinos effective treatments for anxiety and depressive disorders. In a career development plan spanning four years, the applicant has delineated long-term goals and developmental objectives to prepare her to launch a highly productive career in clinical and translational research. The applicant's long-term goals are to become an R01 level investigator in the treatment of prevalent anxiety and depression disorders, to build a programmatic line of research that is focused on making innovative evidence- based treatments available to Latinos, to enhance her research skills and abilities enough to instruct and mentor Latino junior faculty, and to develop a highly productive career as a clinical and translational research scientist. The specific developmental objectives during the award period are to: strengthen knowledge of and experience in the design and implementation of GAD intervention research, particularly a CBT based intervention; develop expertise in providing treatment to GAD patients; strengthen knowledge and skills in the application of advanced statistical techniques relevant to clinical trials research; and improve grant-writing and manuscript preparation skills. . PUBLIC HEALTH RELEVANCE: GAD is a prevalent, chronic, and costly mental-health problem associated with decreased functioning, increased health-service utilization, and high risk for subsequent comorbid major depression. Although significant evidence supports the effectiveness of CBT for the treatment of GAD, Latinos have not benefited equally from these advances. This project seeks to obtain preliminary estimates of the effect size of a culturally adapted, manualized CBT-based intervention for GAD that will lay the foundation for a full trial that will lead to the advancement of treatments for GAD among Spanish-speaking Latinos, particularly Puerto Ricans.