CBT for Latinos with Generalized Anxiety Disorder in the General Medical Sector

描述(由申请人提供)：GAD是一种普遍的、慢性的、代价高昂的精神健康问题，与功能下降、卫生服务利用率增加以及随后合并严重抑郁症的高风险相关。尽管有大量证据支持CBT治疗广泛性AD的有效性，但拉美人并没有从这些进步中同样受益。在有效性和有效性研究中，说西班牙语的拉丁裔通常都被排除在外。为了解决这一差异，至关重要的是将干预措施的临床发展的好处提供给讲西班牙语的拉丁裔人。本申请要求SC1分数对GAD的文化适应的、基于人工CBT的干预进行随机对照研究，以获得其疗效的初步估计，并生成治疗效果大小估计，该估计将为后续动力充足的随机对照试验的设计提供信息。该项目旨在为全面试验奠定基础，这将导致在讲西班牙语的拉丁裔，特别是波多黎各人中推进广泛性AD的治疗。该奖项提供的支持将培养申请者的研究竞争力，以准备一份成功的R01拨款申请，使她能够开发一系列方案研究，重点是向讲西班牙语的拉丁裔人提供有效的焦虑和抑郁障碍治疗。在为期四年的职业发展计划中，申请者勾勒出了长期目标和发展目标，为她在临床和转化性研究中开始高生产率的职业生涯做好准备。申请者的长期目标是成为一名治疗普遍存在的焦虑和抑郁障碍的R01级研究员，建立一系列专注于向拉美裔提供创新的循证治疗的研究计划，提高她的研究技能和能力，足以指导和指导拉美裔初级教师，并发展作为临床和翻译研究科学家的高生产率职业生涯。获奖期间的具体发展目标是：加强设计和实施GAD干预研究，特别是基于CBT的干预研究的知识和经验；发展向GAD患者提供治疗的专门知识；加强与临床试验研究相关的先进统计技术应用方面的知识和技能；以及提高赠款编写和手稿准备技能。。 与公共卫生相关：GAD是一种普遍的、慢性的、代价高昂的精神健康问题，与功能下降、卫生服务利用率增加以及随后并发严重抑郁症的高风险相关。尽管有大量证据支持CBT治疗广泛性AD的有效性，但拉美人并没有从这些进步中同样受益。该项目旨在获得对GAD的文化适应、以CBT为基础的手动干预措施的效果规模的初步估计，这将为全面试验奠定基础，从而在讲西班牙语的拉美裔人，特别是波多黎各人中推进GAD的治疗。

DESCRIPTION (provided by applicant): GAD is a prevalent, chronic, and costly mental-health problem associated with decreased functioning, increased health-service utilization, and high risk for subsequent comorbid major depression. Although significant evidence supports the effectiveness of CBT for the treatment of GAD, Latinos have not benefited equally from these advances. Spanish-speaking Latinos have been routinely excluded in both efficacy and effectiveness studies. To address this disparity, it is essential that the benefits of clinical developments in interventions be made available to Spanish-speaking Latinos. This application requests a SCORE SC1 to conduct a randomized, controlled study of a culturally adapted, manualized CBT-based intervention for GAD to obtain preliminary estimates of its efficacy and to generate a treatment effect size estimate that will inform the design of a subsequent adequately-powered randomized controlled trial. This project seeks to lay the foundation for a full trial that will lead to the advancement of treatments for GAD among Spanish-speaking Latinos, particularly Puerto Ricans. The support provided by this award will foster the research competitiveness of the applicant to prepare a successful R01 grant application that will allow her to develop a programmatic line of research focused on making available to Spanish-speaking Latinos effective treatments for anxiety and depressive disorders. In a career development plan spanning four years, the applicant has delineated long-term goals and developmental objectives to prepare her to launch a highly productive career in clinical and translational research. The applicant's long-term goals are to become an R01 level investigator in the treatment of prevalent anxiety and depression disorders, to build a programmatic line of research that is focused on making innovative evidence- based treatments available to Latinos, to enhance her research skills and abilities enough to instruct and mentor Latino junior faculty, and to develop a highly productive career as a clinical and translational research scientist. The specific developmental objectives during the award period are to: strengthen knowledge of and experience in the design and implementation of GAD intervention research, particularly a CBT based intervention; develop expertise in providing treatment to GAD patients; strengthen knowledge and skills in the application of advanced statistical techniques relevant to clinical trials research; and improve grant-writing and manuscript preparation skills. . PUBLIC HEALTH RELEVANCE: GAD is a prevalent, chronic, and costly mental-health problem associated with decreased functioning, increased health-service utilization, and high risk for subsequent comorbid major depression. Although significant evidence supports the effectiveness of CBT for the treatment of GAD, Latinos have not benefited equally from these advances. This project seeks to obtain preliminary estimates of the effect size of a culturally adapted, manualized CBT-based intervention for GAD that will lay the foundation for a full trial that will lead to the advancement of treatments for GAD among Spanish-speaking Latinos, particularly Puerto Ricans.