CBT for Latinos with Generalized Anxiety Disorder in the General Medical Sector

在普通医疗部门针对患有广泛性焦虑症的拉丁裔进行 CBT

• 批准号: 7687739
• 负责人: MILDRED VERA
• 金额: $ 33.35万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-05 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7687739
• 关键词: Address; Anxiety; Applications Grants; Area; Attention; Award; Caring; Categories; Chronic; Clinical; Clinical Research; Clinical Trials; Communities; Consultations; Data; Depressive disorder; Development; Development Plans; Discipline; Disease; Educational workshop; Effectiveness; Elements; Environment; Evidence based practice; Evidence based treatment; Faculty; Fostering; Foundations; General Population; Generalized Anxiety Disorder; Goals; Grant; Health; Health Services Accessibility; Healthcare; Healthy People 2010; Hispanics; Home environment; Institute of Medicine (U.S.); Intervention; Intervention Studies; Journals; Knowledge; Language; Latino; Lead; Light; Major Depressive Disorder; Manuscripts; Medical; Mental Health; Mentors; Minority; Minority Groups; Monitor; Outcome; Patients; Peer Review; Population; Positioning Attribute; Preparation; Public Health; Puerto Rican; Randomized Controlled Trials; Request for Applications; Research; Research Personnel; Scientist; Techniques; Testing; Translating; Translational Research; Treatment Effectiveness; United States Agency for Healthcare Research and Quality; United States Dept. of Health and Human Services; Work; Writing; base; career; career development; cognitive behavior therapy; depression; design; effective therapy; effectiveness trial; experience; health care service utilization; health related quality of life; high risk; improved; innovation; meetings; programs; public health relevance; research study; skills; social; symposium; treatment effect

DESCRIPTION (provided by applicant): GAD is a prevalent, chronic, and costly mental-health problem associated with decreased functioning, increased health-service utilization, and high risk for subsequent comorbid major depression. Although significant evidence supports the effectiveness of CBT for the treatment of GAD, Latinos have not benefited equally from these advances. Spanish-speaking Latinos have been routinely excluded in both efficacy and effectiveness studies. To address this disparity, it is essential that the benefits of clinical developments in interventions be made available to Spanish-speaking Latinos. This application requests a SCORE SC1 to conduct a randomized, controlled study of a culturally adapted, manualized CBT-based intervention for GAD to obtain preliminary estimates of its efficacy and to generate a treatment effect size estimate that will inform the design of a subsequent adequately-powered randomized controlled trial. This project seeks to lay the foundation for a full trial that will lead to the advancement of treatments for GAD among Spanish-speaking Latinos, particularly Puerto Ricans. The support provided by this award will foster the research competitiveness of the applicant to prepare a successful R01 grant application that will allow her to develop a programmatic line of research focused on making available to Spanish-speaking Latinos effective treatments for anxiety and depressive disorders. In a career development plan spanning four years, the applicant has delineated long-term goals and developmental objectives to prepare her to launch a highly productive career in clinical and translational research. The applicant's long-term goals are to become an R01 level investigator in the treatment of prevalent anxiety and depression disorders, to build a programmatic line of research that is focused on making innovative evidence- based treatments available to Latinos, to enhance her research skills and abilities enough to instruct and mentor Latino junior faculty, and to develop a highly productive career as a clinical and translational research scientist. The specific developmental objectives during the award period are to: strengthen knowledge of and experience in the design and implementation of GAD intervention research, particularly a CBT based intervention; develop expertise in providing treatment to GAD patients; strengthen knowledge and skills in the application of advanced statistical techniques relevant to clinical trials research; and improve grant-writing and manuscript preparation skills. . PUBLIC HEALTH RELEVANCE: GAD is a prevalent, chronic, and costly mental-health problem associated with decreased functioning, increased health-service utilization, and high risk for subsequent comorbid major depression. Although significant evidence supports the effectiveness of CBT for the treatment of GAD, Latinos have not benefited equally from these advances. This project seeks to obtain preliminary estimates of the effect size of a culturally adapted, manualized CBT-based intervention for GAD that will lay the foundation for a full trial that will lead to the advancement of treatments for GAD among Spanish-speaking Latinos, particularly Puerto Ricans.

描述（由申请人提供）：广泛性焦虑症是一种流行的、慢性的、代价高昂的心理健康问题，与功能下降、卫生服务利用增加和随后合并重度抑郁症的高风险相关。虽然有大量证据支持CBT治疗GAD的有效性，但拉丁美洲人并没有从这些进步中平等受益。在疗效和有效性研究中，讲西班牙语的拉丁美洲人通常被排除在外。为了解决这一差距，至关重要的是，干预措施的临床发展的好处提供给讲西班牙语的拉丁美洲人。本申请要求SCORE SC 1对GAD进行一项文化适应性、手动化基于CBT的干预的随机对照研究，以获得其疗效的初步估计值，并生成治疗效应量估计值，该估计值将为后续充分把握度的随机对照试验的设计提供信息。该项目旨在为一项全面试验奠定基础，这将导致在讲西班牙语的拉丁美洲人，特别是波多黎各人中促进GAD的治疗。该奖项提供的支持将促进申请人的研究竞争力，以准备一个成功的R 01资助申请，这将使她能够开发一个专注于为讲西班牙语的拉丁美洲人提供有效治疗焦虑和抑郁症的研究项目。在为期四年的职业发展计划中，申请人已经划定了长期目标和发展目标，为她在临床和转化研究领域开展高效的职业生涯做好准备。申请人的长期目标是成为普遍焦虑和抑郁障碍治疗领域的R 01级研究员，建立一个专注于为拉丁裔提供创新循证治疗的项目研究路线，提高她的研究技能和能力足以指导和指导拉丁裔初级教师，并发展作为临床和转化研究科学家的高产职业生涯。奖励期间的具体发展目标是：加强在设计和实施性别与焦虑干预研究方面的知识和经验，特别是基于认知行为疗法的干预;发展为性别与焦虑患者提供治疗的专业知识;加强在应用与临床试验研究相关的先进统计技术方面的知识和技能;提高赠款写作和手稿准备技能。. 公共卫生关系：广泛性焦虑症是一种流行的、慢性的、代价高昂的心理健康问题，与功能下降、卫生服务利用率增加以及后续共病重度抑郁症的高风险相关。虽然有大量证据支持CBT治疗GAD的有效性，但拉丁美洲人并没有从这些进步中平等受益。该项目旨在获得初步估计的效果大小的文化适应，手动基于CBT的干预GAD，这将奠定一个完整的试验，将导致GAD治疗西班牙语的拉丁美洲人，特别是波多黎各人的进步的基础。