Biostatistics

生物统计核心将为西雅图癌症联合会乳房提供必要的生物统计支持 孢子调查员。核心链接研究设计、数据收集、测量和分析 研究涉及基础科学的孢子调查人员所研究的批判性假设和问题， 流行病学、人口研究和临床研究。生物统计核心将对孢子做出贡献 通过以下具体目标执行使命： 1.研究设计：确定研究假设、研究人群和实验测量 回答感兴趣的研究问题，避免系统偏差，并确保高可能性 检测具有生物学意义的效应。 2.分析和解释：确定和实施适当的量化方法以解决 感兴趣的科学问题，并提供关于证据支持的有效统计推断 各种研究假设。 3.必要时的方法学发展：修改现有方法并开展新的研究 在适当的情况下，解决孢子项目引起的问题的设计和方法 统计方法是不够的。 孢子生物统计学家一直密切参与孢子中的项目。他们将继续 作为每个项目的联合调查员进行协作，以确保研究设计良好且适当 分析和解读。此外，核心还将为孢子调查人员提供咨询服务 研究发展计划和职业发展计划下的项目。《核心》 调查人员具有多样化和互补性的专业知识，可以使用来自广泛的数据进行分析 各种实验技术。对于其中一些技术，分析方法仍在发展中。 核心调查人员是联盟生物统计研究小组的一部分，这些小组是以下领域的领导者 生物标记物开发、计算生物学和生物信息学。总而言之，Core装备齐全 以满足不同的需求，并满足乳房孢子的翻译目标。

The Biostatistics Core will provide essential biostatistical support to Seattle Cancer Consortium Breast SPORE investigators. The Core links study design, data collection, measurements, and analysis to the critical hypotheses and questions studied by SPORE investigators whose research involves basic sciences, epidemiology, population studies, and clinical research. The Biostatistics Core will contribute to the SPORE mission through the following specific aims: 1. Study design: Define study hypotheses, study populations, and experimental measurements to answer research questions of interest, avoid systematic bias, and ensure a high likelihood of detection of biologically meaningful effects. 2. Analysis and interpretation: Identify and implement appropriate quantitative methods to address scientific questions of interest and provide valid statistical inferences about the evidence supporting the various study hypotheses. 3. Methodological development when needed: Modify existing approaches and develop novel study designs and methods to address problems arising from SPORE projects, where appropriate statistical methods are inadequate. SPORE biostatisticians have been closely involved with the projects in the SPORE. They will continue to collaborate as co-investigators on each project to ensure that studies are well designed and appropriately analyzed and interpreted. Moreover, the Core will provide consulting services to SPORE investigators for projects under the Research Developmental Program and the Career Development Program. The Core investigators have diverse and complementary expertise, and can conduct analyses using data from a wide variety of experimental technologies. For some of these technologies, analytic methods are still evolving. Core investigators are part of Consortium biostatistical research groups that are leaders in the areas of biomarker development, computational biology, and bioinformatics. In summary, the Core is well equipped to meet the diverse needs and address the translational aims of the Breast SPORE.