Developmental Research Program

发展研究计划

• 批准号: 7976130
• 负责人: Marc Ladanyi
• 金额: $ 4.55万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7976130
• 关键词: Address; Advisory Committees; Animals; Award; Basic Science; Biology; Budgets; Clinical; Clinical Investigator; Complement; Data; Development; Diagnosis; Disease; Eligibility Determination; Faculty; Funding; Future; Generations; Goals; Human; International; Intervention; Investigator-Initiated Research; Knowledge; Leadership; Measurement; Memorial Sloan-Kettering Cancer Center; Natural History; Newly Diagnosed; Pathogenesis; Patients; Pilot Projects; Process; Recruitment Activity; Reproduction spores; Research; Research Personnel; Research Project Grants; Scientific Evaluation; Seeds; Staging; Talents; Testing; Translational Research; base; career; improved; innovation; outcome forecast; preference; programs; sarcoma; soft tissue; success

Approximately 50% of patients with newly diagnosed sarcoma eventually die of disease. The purpose of the Developmental Research Program of the MSKCC SPORE in Soft Tissue Sarcoma is to support innovative translational research projects in sarcoma. The translational research projects in this program aim to use knowledge of animal and human sarcoma biology to develop and test interventions related to improving diagnosis, prognosis, and treatment of pafients with soft fissue sarcoma. This program will allow us to respond quickly to new opportunifies in translational research and will help us recruit new scientific talent into our SPORE and, more broadly, into sarcomarelevant research. The specific aims of the Developmental Research Program are: 1) to provide seed funding for innovative, investigator-initiated research in the biology, pathogenesis, progression, and natural history of sarcoma, 2) to fund research with exceptional potential to advance the translational research goals of the SPORE, and 3) to establish a mechanism for strategic interactions with other SPOREs and other major national and international research centers. We are budgeting $450,000 yeariy for this program including $50,000 from the SPORE award itself and $400,000 in MSKCC institutional funds. The priority for funding will be those inifiafives considered most creafive and of the highest scientific quality. Preference will be given to projects that complement the long-term research goals of the SPORE and advance our translational research objecfives. The executive committee can also solicit and fund experimental or clinical initiatives that address an urgent and specific need in the MSKCC SPORE in Soft Tissue Sarcoma program or a unique research opportunity. The internal scientific advisory committee, under the chairmanship of Murray F. Brennan, MD, will review applications to determine priorities for use of these funds and will annually select projects for one to two years of funding. The projects that appear most promising after two years of funding will be considered for incorporation into the SPORE as Research Projects, either in current or future funding cycles.

大约 50% 的新诊断肉瘤患者最终死于疾病。这 MSKCC SPORE 软组织肉瘤发展研究计划的目的是 支持肉瘤的创新转化研究项目。转化研究项目 该计划旨在利用动物和人类肉瘤生物学知识来开发和测试 与改善软组织患者的诊断、预后和治疗相关的干预措施 肉瘤。该计划将使我们能够快速响应转化研究的新机遇 并将帮助我们招募新的科学人才加入我们的孢子，更广泛地说，进入肉瘤相关领域 研究。发展研究计划的具体目标是： 1) 提供 为生物学、发病机制、进展等领域的创新型、研究者发起的研究提供种子资金 和肉瘤的自然史，2）资助具有特殊潜力的研究，以推进 SPORE 的转化研究目标，以及 3) 建立战略机制 与其他 SPORE 以及其他主要国家和国际研究中心的互动。 我们每年为该计划预算 450,000 美元，其中 50,000 美元来自 SPORE 奖本身 以及 400,000 美元的 MSKCC 机构基金。资助的优先事项将是那些倡议 被认为是最具创造力和最高科学质量的。将优先考虑项目 补充 SPORE 的长期研究目标并推进我们的转化 研究目标。执行委员会还可以征求和资助实验或临床 解决 MSKCC SPORE 在软组织肉瘤方面的紧急和具体需求的举措 计划或独特的研究机会。内部科学顾问委员会，隶属于 默里·F·布伦南 (Murray F. Brennan) 医学博士的主席将审查申请，以确定使用的优先顺序 这些基金每年都会选择资助一到两年的项目。那些项目 两年资助后显得最有前途的项目将被考虑纳入 SPORE 作为研究项目，无论是在当前还是未来的资助周期中。