Biostatistics and Bioinformatics

生物统计和生物信息学核心B将在以下方面提供统计和生物信息学支助和专门知识 根据项目和其他需要进行实验设计、数据分析和结果解释 核心，以实现其特定目标。在波兰的研究需要各种统计和生物信息学 数据分析策略，如对时间历程实验数据进行建模，测试激酶的协同作用 抑制剂组合，并分析RNA表达和DNA拷贝数的基因组图谱数据。在……里面 加法。核心B将开发和维护生物信息学基础设施，以实现协作和数据 研究项目之间的共享。该基础设施包括：1)基因签名数据库2)体细胞 突变数据库和功能表征工具，以及3)虚拟细胞系储存库。范围广泛的 生物信息学、计算和统计技术将被应用于创建这个基础设施。

The Biostatistics and Bioinformatics Core B will provide statistics and bioinformatics support and expertise in experimental design, data analysis and interpretation ofthe results as needed by the Projects and other Cores to achieve their Specific Aims. The studies in this POl require a variety of statistical and bioinformatic data analysis strategies such as modeling time course experiment data, tesfing synergisfic effect of kinase inhibitor combination, and analyzing genomic profiling data of RNA expression and DNA copy number. In addition. Core B will develop and maintain a bioinformatics infrastructure to enable collaboration and data sharing among research projects. This infrastructure includes: 1) a gene signature database 2) a somafic mutation database and functional characterization tools, and 3) a virtual cell line repository. A broad range of bioinformatics, computational, and statistical techniques will be applied to create this infrastructure.