An objective snoring index and its association with carotid atherosclerosis

客观打鼾指数及其与颈动脉粥样硬化的关系

• 批准号: 8339355
• 负责人: Jinyoung Kim
• 金额: $ 9.19万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-28 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8339355
• 关键词: Affect; Age; Alcohol consumption; Animal Model; Antihypertensive Agents; Apnea; Asians; Atherosclerosis; Biological Markers; Blood Pressure; Body mass index; Breathing; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Carotid Atherosclerotic Disease; Case-Control Studies; Cerebrovascular Disorders; Chronic Disease; Cohort Studies; DNA; Data; Development; Devices; Diabetes Mellitus; Disease; Early Diagnosis; Early treatment; Elderly; Elements; Evaluation; Event; Faculty; Foundations; Frequencies; Future; Gender; Genome; Goals; Health; Home environment; Hour; Inflammatory; Intervention Studies; Knowledge; Korea; Koreans; Lead; Life Style; Lipids; Longitudinal Studies; Measurement; Measures; Mediating; Nursing Research; Nursing Schools; Obesity; Obstructive Sleep Apnea; Outcome; Oxidative Stress; Parents; Participant; Pharmaceutical Preparations; Phase; Physical Examination; Physical activity; Population; Positioning Attribute; Questionnaires; Receiver Operating Characteristics; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Personnel; Risk; Risk Factors; Risk Reduction; Sampling; Sensitivity and Specificity; Severities; Sleep; Smoking; Snoring; Symptoms; Technology; Thick; Time; Training Programs; United States; Vascular Diseases; Writing; base; cardiovascular risk factor; career; career development; cerebrovascular; cohort; cost; diabetic; epidemiology study; genetic analysis; human subject; indexing; innovation; intima media; longitudinal analysis; middle age; novel; peer; prevent; programs; research study; sound; transmission process; vibration

DESCRIPTION (provided by applicant): The candidate's overall long-term goal is to become an independent investigator with a program of research on snoring and its association with cardiovascular disease and atherosclerosis. On the continuum of severity of sleep-related breathing disorders, snoring is at the mildest end of the spectrum of which obstructive sleep apnea (OSA) is at the more severe end. Although OSA has been associated with cardio/cerebrovascular disease, effects of snoring alone on health outcomes are largely unknown. In addition, most studies on snoring have used questionnaires to measure snoring, emphasizing that an objective validated measurement of snoring is needed. The goals of the proposed research are (a) to determine the objective snoring index that is optimally associated with carotid atherosclerosis, independent of potential cardiovascular confounders, in a case-control study (K99 phase) and (b) to validate the independent association in a large cohort and examine interactions among snoring, OSA, and obesity that are strongly related to carotid atherosclerosis (R00 phase). We have the opportunity to use the Korean Genome Epidemiology Study (KoGES), an ongoing cohort study of Korean middle-aged and older adults, to achieve the research goals. To date, 5,020 randomly selected participants have undergone biennial comprehensive physical examinations that include carotid intima-media thickness and other variables related to cardiovascular risk. During the K99 phase, we will conduct home-based sleep studies for 100 non-apneic snorers and 100 age-, body-mass index-, and gender-matched normal-controls from the KoGES, to measure objective snoring using a portable sleep device. Objective snoring measurement will include (a) the frequency of snoring episodes, (b) the percentage of snoring time during whole sleeping hours, and (c) snoring sound intensity. During the R00 phase, we will do sleep studies and assess snoring in a large cohort that will consist of 800 KoGES participants with different degrees of snoring. Using an existing ongoing large cohort with comprehensive data on participants' health outcomes is a low-cost and very innovative approach to achieving the ultimate goal of the proposed study. There is a substantial infrastructure and the candidate will have access to multiple other elements at no cost, such as carotid IMT, biomarkers, and DNA for future genetic analyses. Measuring snoring objectively in the home environment is methodologically innovative and will facilitate future snoring and nursing research. Given that the Asian population is growing rapidly in the United States, this study will be significant for the health of Asians in the US population To successfully conduct the proposed research and achieve overall long-term career goals, the candidate will actively participate in a training program during the K99 phase on (a) sleep- related breathing disorders, including snoring~ (b) carotid atherosclerosis measure~ (c) ambulatory technologies to objectively measure snoring~ (d) scientific writing, peer revie, and disseminating~ and (e) professional development for career advancement into a faculty position in a nursing school.

描述（由申请人提供）：候选人的总体长期目标是成为一名独立的研究人员，研究打鼾及其与心血管疾病和动脉粥样硬化的关系。在睡眠相关呼吸障碍的严重程度的连续体中，打鼾处于最温和的一端，而阻塞性睡眠呼吸暂停（OSA）处于更严重的一端。虽然OSA与心脑血管疾病有关，但打鼾单独对健康结果的影响在很大程度上是未知的。此外，大多数关于打鼾的研究都使用问卷来测量打鼾，强调需要客观有效的打鼾测量。本研究的目的是：（a）在病例对照研究中，确定客观打鼾指数与颈动脉粥样硬化的最佳相关性，独立于潜在的心血管混杂因素（K99期）和（B）以验证大队列中的独立关联并检查打鼾、OSA、和肥胖与颈动脉粥样硬化密切相关（R 00期）。 我们有机会使用韩国基因组流行病学研究（KoGES），这是一项正在进行的韩国中年和老年人队列研究，以实现研究目标。迄今为止，5，020名随机选择的参与者接受了两年一次的全面体检，包括颈动脉内膜中层厚度和其他与心血管风险相关的变量。在K99阶段，我们将对来自KoGES的100名非呼吸暂停打鼾者和100名年龄、体重指数和性别匹配的正常对照者进行基于家庭的睡眠研究，以使用便携式睡眠设备测量客观打鼾。 客观打鼾测量将包括（a）打鼾发作的频率，（B）打鼾时间在整个睡眠时间内的百分比，和（c）打鼾声音强度。在R 00阶段，我们将进行睡眠研究，并在一个由800名不同程度打鼾的KoGES参与者组成的大型队列中评估打鼾。使用现有的正在进行的大型队列，以及参与者健康结果的综合数据，是实现拟议研究最终目标的低成本和非常创新的方法。 有大量的基础设施，候选人将可以免费获得多种其他元素，如颈动脉IMT，生物标志物和DNA用于未来的遗传分析。在家庭环境中客观地测量打鼾是方法上的创新，将促进未来的打鼾和护理研究。鉴于美国亚裔人口正在迅速增长，本研究对美国亚裔人口的健康具有重要意义。为了成功开展拟议的研究并实现总体长期职业目标，候选人将在K99阶段积极参加培训计划，内容涉及（a）睡眠相关呼吸障碍，包括打鼾~（B）颈动脉粥样硬化测量~（c）客观测量打鼾的流动技术~（d）科学写作、同行评审和传播~和（e）职业发展，以晋升为护理学校的教师职位。