An Objective Snoring Index and its Association with Carotid Atherosclerosis

客观打鼾指数及其与颈动脉粥样硬化的关系

• 批准号: 8733203
• 负责人: Jinyoung Kim
• 金额: $ 24.12万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-28 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8733203
• 关键词: Affect; Age; Alcohol consumption; Animal Model; Antihypertensive Agents; Apnea; Asians; Atherosclerosis; Biological Markers; Blood Pressure; Body mass index; Breathing; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Carotid Atherosclerotic Disease; Case-Control Studies; Cerebrovascular Disorders; Chronic Disease; Cohort Studies; DNA; Data; Development; Devices; Diabetes Mellitus; Disease; Early Diagnosis; Early Intervention; Elderly; Elements; Evaluation; Event; Faculty; Foundations; Frequencies; Future; Gender; Genome; Goals; Health; Home environment; Hour; Inflammatory; Intervention Studies; Knowledge; Korea; Koreans; Lead; Life Style; Lipids; Longitudinal Studies; Measurement; Measures; Mediating; Nursing Research; Nursing Schools; Obesity; Obstructive Sleep Apnea; Outcome; Oxidative Stress; Parents; Participant; Peer Review; Pharmaceutical Preparations; Phase; Physical Examination; Physical activity; Population; Positioning Attribute; Questionnaires; Receiver Operating Characteristics; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Personnel; Risk; Risk Factors; Risk Reduction; Sampling; Sensitivity and Specificity; Severities; Sleep; Smoking; Snoring; Symptoms; Technology; Thick; Time; Training Programs; United States; Vascular Diseases; Writing; base; cardiovascular risk factor; career; career development; cerebrovascular; cohort; cost; diabetic; epidemiology study; genetic analysis; human subject; indexing; innovation; intima media; longitudinal analysis; middle age; novel; prevent; programs; research study; sound; transmission process; vibration

PROJECT SUMMARY: The candidate's overall long-term goal is to become an independent investigator with a program of research on snoring and its association with cardiovascular disease and atherosclerosis. On the continuum of severity of sleep-related breathing disorders, snoring is at the mildest end of the spectrum of which obstructive sleep apnea (OSA) is at the more severe end. Although OSA has been associated with cardio/cerebrovascular disease, effects of snoring alone on health outcomes are largely unknown. In addition, most studies on snoring have used questionnaires to measure snoring, emphasizing that an objective validated measurement of snoring is needed. The goals of the proposed research are (a) to determine the objective snoring index that is optimally associated with carotid atherosclerosis, independent of potential cardiovascular confounders, in a case-control study (K99 phase) and (b) to validate the independent association in a large cohort and examine interactions among snoring, OSA, and obesity that are strongly related to carotid atherosclerosis (R00 phase). We have the opportunity to use the Korean Genome Epidemiology Study (KoGES), an ongoing cohort study of Korean middle-aged and older adults, to achieve the research goals. To date, 5,020 randomly selected participants have undergone biennial comprehensive physical examinations that include carotid intima-media thickness and other variables related to cardiovascular risk. During the K99 phase, we will conduct home-based sleep studies for 100 non-apneic snorers and 100 age-, body-mass index-, and gender-matched normal-controls from the KoGES, to measure objective snoring using a portable sleep device. Objective snoring measurement will include (a) the frequency of snoring episodes, (b) the percentage of snoring time during whole sleeping hours, and (c) snoring sound intensity. During the R00 phase, we will do sleep studies and assess snoring in a large cohort that will consist of 800 KoGES participants with different degrees of snoring. Using an existing ongoing large cohort with comprehensive data on participants' health outcomes is a low-cost and very innovative approach to achieving the ultimate goal of the proposed study. There is a substantial infrastructure and the candidate will have access to multiple other elements at no cost, such as carotid IMT, biomarkers, and DNA for future genetic analyses. Measuring snoring objectively in the home environment is methodologically innovative and will facilitate future snoring and nursing research. Given that the Asian population is growing rapidly in the United States, this study will be significant for the health of Asians in the US population. To successfully conduct the proposed research and achieve overall long-term career goals, the candidate will actively participate in a training program during the K99 phase on (a) sleep- related breathing disorders, including snoring~ (b) carotid atherosclerosis measure~ (c) ambulatory technologies to objectively measure snoring~ (d) scientific writing, peer review, and disseminating~ and (e) professional development for career advancement into a faculty position in a nursing school.

项目总结：候选人的总体长期目标是成为一名独立的调查员 关于打鼾症及其与心血管疾病和动脉粥样硬化的关系的研究计划。论 睡眠相关呼吸障碍的严重程度的连续体，鼾症是睡眠呼吸障碍谱中最轻微的一端 哪种阻塞性睡眠呼吸暂停(OSA)更严重。尽管OSA一直被认为与 在心脑血管疾病方面，仅打鼾症对健康结果的影响在很大程度上是未知的。此外, 大多数关于鼾症的研究都使用问卷来测量鼾声，强调客观有效 需要对鼾声进行测量。拟议研究的目标是：(A)确定目标 鼾症指数与颈动脉粥样硬化的最佳相关性，与潜在的心血管疾病无关 混杂因素，病例对照研究(K99阶段)和(B)在大范围内验证独立相关性 对与颈动脉密切相关的鼾症、阻塞性睡眠呼吸暂停综合征和肥胖之间的相互作用进行分类和检查 动脉粥样硬化(R00期)。我们有机会利用韩国基因组流行病学研究 (KoGES)，这是一项正在进行的韩国中老年人队列研究，以实现研究目标。至 到目前为止，5020名随机挑选的参与者接受了两年一次的全面体检， 包括颈动脉内中膜厚度和其他与心血管风险相关的变量。在K99阶段， 我们将对100名非呼吸暂停打鼾者和100名年龄、体重指数进行家庭睡眠研究，以及 来自KoGES的性别匹配的正常对照组，使用便携式睡眠设备来测量客观的鼾声。 客观的鼾声测量将包括(A)鼾症发作的频率，(B) 整个睡眠时间，以及(C)鼾声强度。在R00阶段，我们将 在一个由800名不同性别的KoGES参与者组成的大型队列中进行睡眠研究和评估打鼾症 鼾声的程度。使用现有的具有关于参与者健康的全面数据的持续大型队列 成果是实现拟议研究最终目标的一种低成本和非常创新的方法。 有大量的基础设施，候选人将可以免费访问多个其他元素， 例如颈动脉IMT、生物标记物和DNA，用于未来的遗传分析。客观测量打鼾者的鼾声 家庭环境在方法上是创新的，将促进未来的鼾症和护理研究。vt.给出 美国的亚洲人口正在迅速增长，这项研究将对美国人的健康具有重要意义 美国人口中的亚洲人。成功地进行拟议的研究并实现整体的长期 职业目标，候选人将在K99阶段积极参加关于(A)睡眠的培训计划- 相关呼吸障碍，包括打鼾症~(B)颈动脉粥样硬化测量~(C)非卧床技术 客观地衡量打鼾者的科学写作、同行评议和传播专业知识 为职业发展而发展成为护理学校的教师职位。