DEVELOPMENT OF SOFTWARE FOR IMAGE ANALYSIS, DISPLAY, AND MODELING

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们继续开发和支持IMOD软件包，用于断层重建和图像显示、建模和分析。 主要的里程碑是首次发布用于生成断层图像的eTomo图形界面（在其他地方描述），以及发布Microsoft Windows和Macintosh OS X操作系统的全功能版本。 在过去的一年中，增加了一些重要的功能，包括从CCD相机图像中自动删除X射线的程序，在将图像加载到3dmod显示和建模程序时将图像进行分组的能力，以及其他更改，以方便处理非常大的数据集。 我们开发了一种新的方法，为程序提供参数输入，使其更容易手动运行或从其他程序，如eTomo，允许新的选项添加到程序中，而不破坏现有的代码和命令文件，并集中规范和文档的程序选项。 大约有15个Fortran程序已经转换成新的方法。 在文档方面也有重大改进：3dmod指南被修订并大大扩展，以提供对该程序的全面介绍;断层扫描指南被彻底修订，以描述如何通过eTomo工作;还发布了构建断层图像的教程，以及完整的双轴数据集。 随着新平台版本的发布，该软件的下载量比以往任何时候都高。 在2003年11月主要版本发布后的两周加上2003年2月/3月的7周内，有来自299个不同IP地址的下载，其中49%用于Windows，25%用于Linux，21%用于Macintosh，5%用于SGI。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have continued development and support of the IMOD software package for tomographic reconstruction and image display, modeling, and analysis. Major milestones were the first release of the eTomo graphical interface for tomogram generation (described elsewhere) and the release of fully functional versions for Microsoft Windows and Macintosh OS X operating systems. Some significant functionality was added in the past year, including a program for automatic removal of X-rays from CCD camera images, the ability to bin down images when loading them into the 3dmod display and modeling program, and other changes to facilitate working with very large data sets. We developed a new method for providing parameter input to programs, to make it easier to run them manually or from other programs such as eTomo, to allow new options to be added to programs without breaking existing code and command files, and to centralize the specification and documentation of program options. About 15 Fortran programs have been converted to the new method. There were also major improvements in documentation: a guide to 3dmod was revised and greatly expanded to provide a comprehensive introduction to the program; a guide to tomography was thoroughly revised to describe how to work through eTomo; and a tutorial for building tomograms was also released, together with a complete dual-axis data set. With the release of versions for new platforms, downloads of the software are higher than ever. For the 2 weeks after the major version release in November 2003 plus 7 weeks in February/March 2003, there were downloads from 299 distinct IP addresses, of which 49% were for Windows, 25% for Linux, 21% for Macintosh, and 5% for SGI.