RRP17P IS A EXONUCLEASE REQUIRED FOR 5' END PROCESSING OF PRE-60S RIBOSOMAL RNA
RRP17P 是 60S 前核糖体 RNA 5 端加工所需的核酸外切酶
基本信息
- 批准号:8361567
- 负责人:
- 金额:$ 0.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-03-01 至 2012-03-31
- 项目状态:已结题
- 来源:
- 关键词:BindingBiogenesisCatalytic DomainCell NucleolusCellsDigestionEnsureEukaryotaExonucleaseFamilyFundingGrantLinkMolecularNational Center for Research ResourcesNuclearPaperPathway interactionsPrincipal InvestigatorProcessProductionPublishingRNA, ribosomal, 25SResearchResearch InfrastructureResourcesRibosomal RNARibosomesSeriesSourceUnited States National Institutes of HealthWorkcostmacromoleculemembernucleaseparallel processingspleen exonuclease
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Ribosomal processing requires a series of endo- and exonucleolytic steps for the production of mature ribosomes, of which most have been described. To ensure ribosome synthesis, 3' end formation of rRNA uses multiple nucleases acting in parallel; however, a similar parallel mechanism had not been described for 5' end maturation. Here, we identify Rrp17p as a previously unidentified 5'-3' exonuclease essential for ribosome biogenesis, functioning with Rat1p in a parallel processing pathway analogous to that of 3' end formation. Rrp17p is required for efficient exonuclease digestion of the mature 5' ends of 5.8S(S) and 25S rRNAs, contains a catalytic domain close to its N terminus, and is highly conserved among higher eukaryotes, being a member of a family of exonucleases. We show that Rrp17p binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery, and provide evidence for physical and functional links between late 60S subunit processing and export. A paper describing this work has been published (M. Oeffinger, D. Zenklusen, A. Ferguson, K.E. Wei, A. El Hage, D. Tollervey, B.T. Chait, R.H. Singer, M.P. Rout "Rrp17p Is a Eukaryotic Exonuclease Required for 50 End Processing of Pre-60S Ribosomal RNA" Molecular Cell, 36 (2009) 768-781).
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAEL P ROUT其他文献
MICHAEL P ROUT的其他文献
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{{ truncateString('MICHAEL P ROUT', 18)}}的其他基金
Altered Communication between the nucleus and the mitochondria under oncogenic states
致癌状态下细胞核与线粒体之间通讯的改变
- 批准号:
10016218 - 财政年份:2019
- 资助金额:
$ 0.26万 - 项目类别:
Altered Communication between the nucleus and the mitochondria under oncogenic states
致癌状态下细胞核与线粒体之间通讯的改变
- 批准号:
10688189 - 财政年份:2019
- 资助金额:
$ 0.26万 - 项目类别:
Altered Communication between the nucleus and the mitochondria under oncogenic states
致癌状态下细胞核与线粒体之间通讯的改变
- 批准号:
10248415 - 财政年份:2019
- 资助金额:
$ 0.26万 - 项目类别:
Altered Communication between the nucleus and the mitochondria under oncogenic states
致癌状态下细胞核与线粒体之间通讯的改变
- 批准号:
9764927 - 财政年份:2019
- 资助金额:
$ 0.26万 - 项目类别:
National Center for Dynamic Interactome Research
国家动态相互作用组研究中心
- 批准号:
9063390 - 财政年份:2015
- 资助金额:
$ 0.26万 - 项目类别:
Equipment Supplement for the National Center for Dynamic Interactome Research
国家动态相互作用组研究中心的设备补充
- 批准号:
10392609 - 财政年份:2014
- 资助金额:
$ 0.26万 - 项目类别:
National Center for Dynamic Interactome Research
国家动态相互作用组研究中心
- 批准号:
10401758 - 财政年份:2014
- 资助金额:
$ 0.26万 - 项目类别:
National Center for Dynamic Interactome Research
国家动态相互作用组研究中心
- 批准号:
10621352 - 财政年份:2014
- 资助金额:
$ 0.26万 - 项目类别:
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