A NOVEL HIGH-CAPACITY ION TRAP-QUADRUPOLE TANDEM MASS SPECTROMETER

新型大容量离子阱四极杆串联质谱仪

基本信息

  • 批准号:
    8361486
  • 负责人:
  • 金额:
    $ 2.61万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-03-01 至 2012-03-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have recently developed a novel high capacity ion trap-quadrupole mass spectrometer, which we have described previously: A.N. Krutchinsky, H. Cohen, B.T. Chait A novel high-capacity ion trap-quadrupole tandem mass spectrometer Int J Mass Spectrom, 268 (2007) 93-105 and for which we have been granted a US patent. We have continued this development by constructing a second generation instrument as described below: A high-capacity ion trap coupled to a time-of-flight(TOF) mass spectrometer has been developed to carry out comprehensive linked scan analysis of all stored ions in the ion trap. The approach involves a novel tapered geometry high-capacity ion trap that can store more than 10^6 ions (range 8004000 m/z) without degrading its performance. Ions are stored and scanned out from the high-capacity ion trap as a function of m/z, collisionally fragmented and analyzed by TOF. Accurate mass analysis is achieved on both the precursor and fragments of all species ejected from the ion trap. We demonstrate the approach for comprehensive linked-scan identification of phosphopeptides in mixtures with their corresponding unphosphorylated peptides. A paper describing this work has been published: S. Myung, H. Cohen, D. Feny¿, J.C. Padovan, A.N. Krutchinsky, B.T. Chait. "High-capacity ion trap coupled to a time-of-flight mass spectrometer for comprehensive linked scans with no scanning losses", International Journal of Mass Spectrometry 2010. In press
这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的, 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量, 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们最近开发了一种新型的高容量离子阱-四极杆质谱仪,我们之前已经描述过: A.N. Krutchinsky,H.科恩,B.T.一种新型高容量离子阱-四极杆串联质谱仪Int J Mass Spectrom,268(2007)93-105 我们已经获得了美国专利 我们通过构建第二代仪器来继续这一开发,如下所述: 一个高容量的离子阱耦合到飞行时间(TOF)质谱仪已经开发出进行全面的连锁扫描分析的所有存储的离子在离子阱。该方法涉及一种新颖的锥形几何形状的高容量离子阱,可以存储超过10^6个离子(范围8004000 m/z)而不降低其性能。离子被存储并作为m/z的函数从高容量离子阱中扫描出来,碰撞破碎并通过TOF分析。对从离子阱喷射出的所有物质的前体和碎片都实现了精确的质量分析。我们展示了全面的连接扫描识别磷酸肽与其相应的非磷酸化肽的混合物的方法。 已经发表了一篇描述这项工作的论文: S. Myung,H.科恩,D. J.C.费尼Padovan,A.N. Krutchinsky,B.T.查特“高容量离子阱耦合到飞行时间质谱仪,用于无扫描损失的综合链接扫描”,国际质谱杂志2010年。In press

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

SUNNIE MYUNG其他文献

SUNNIE MYUNG的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('SUNNIE MYUNG', 18)}}的其他基金

DESIGN/CONSTRUCT/TEST A NEW MASS SPECTROM FOR PROFILING PHOSPHORYLATION SITES
设计/构建/测试用于分析磷酸化位点的新质谱
  • 批准号:
    8361498
  • 财政年份:
    2011
  • 资助金额:
    $ 2.61万
  • 项目类别:
A NOVEL HIGH-CAPACITY ION TRAP-QUADRUPOLE TANDEM MASS SPECTROMETER
新型大容量离子阱四极杆串联质谱仪
  • 批准号:
    8169101
  • 财政年份:
    2010
  • 资助金额:
    $ 2.61万
  • 项目类别:
DESIGN/CONSTRUCT/TEST A NEW MASS SPECTROM FOR PROFILING PHOSPHORYLATION SITES
设计/构建/测试用于分析磷酸化位点的新质谱
  • 批准号:
    8169114
  • 财政年份:
    2010
  • 资助金额:
    $ 2.61万
  • 项目类别:
Novel Mass Spectrometer for Comprhensive No-Loss MS/MS of All Stored Ions
用于所有存储离子的全面无损 MS/MS 的新型质谱仪
  • 批准号:
    7806394
  • 财政年份:
    2008
  • 资助金额:
    $ 2.61万
  • 项目类别:
Novel Mass Spectrometer for Comprhensive No-Loss MS/MS of All Stored Ions
用于所有存储离子的全面无损 MS/MS 的新型质谱仪
  • 批准号:
    7555080
  • 财政年份:
    2008
  • 资助金额:
    $ 2.61万
  • 项目类别:
Novel Mass Spectrometer for Comprhensive No-Loss MS/MS of All Stored Ions
用于所有存储离子的全面无损 MS/MS 的新型质谱仪
  • 批准号:
    7405872
  • 财政年份:
    2008
  • 资助金额:
    $ 2.61万
  • 项目类别:

相似国自然基金

水稻边界发育缺陷突变体abnormal boundary development(abd)的基因克隆与功能分析
  • 批准号:
    32070202
  • 批准年份:
    2020
  • 资助金额:
    58 万元
  • 项目类别:
    面上项目
Development of a Linear Stochastic Model for Wind Field Reconstruction from Limited Measurement Data
  • 批准号:
  • 批准年份:
    2020
  • 资助金额:
    40 万元
  • 项目类别:

相似海外基金

The commercialisation of development funding and changing nature of basic services provision
发展资金的商业化和基本服务提供性质的变化
  • 批准号:
    ES/Y010329/1
  • 财政年份:
    2023
  • 资助金额:
    $ 2.61万
  • 项目类别:
    Fellowship
Development of a Trusted and Verified R&D Funding Vault
开发可信且经过验证的 R
  • 批准号:
    10055736
  • 财政年份:
    2023
  • 资助金额:
    $ 2.61万
  • 项目类别:
    Collaborative R&D
Earmarked funding and the effectiveness of international development organizations (EF-IO)
专用资金和国际发展组织的有效性(EF-IO)
  • 批准号:
    MR/V022148/1
  • 财政年份:
    2022
  • 资助金额:
    $ 2.61万
  • 项目类别:
    Fellowship
Grant Insights through Research & Development (GIRD): Using Big Data Centered Mixed Methods to Explain Variances in Grant Funding and Outcomes at Two-Year Colleges
通过研究授予见解
  • 批准号:
    2202169
  • 财政年份:
    2022
  • 资助金额:
    $ 2.61万
  • 项目类别:
    Standard Grant
Tarian Group Ltd proposal to seek funding and support for the accelerated development of an innovative solution that enables digital systems integration within healthcare, improving data flow between Primary, Secondary Care and patients.
Tarian Group Ltd 提议寻求资金和支持,以加速开发创新解决方案,从而实现医疗保健中的数字系统集成,改善初级、二级护理和患者之间的数据流。
  • 批准号:
    10044304
  • 财政年份:
    2022
  • 资助金额:
    $ 2.61万
  • 项目类别:
    Grant for R&D
TEXAS ANIMAL FEED REGULATORY PROGRAM STANDARDS DEVELOPMENT AND MAINTENANCE OF THE ANIMAL FEED REGULATORY PROGRAM STANDARDS FLEXIBLE FUNDING MODEL COMPLIANCE AND ENFORCEMENT EXPANSION SUPPLEMENT
德克萨斯州动物饲料监管计划标准 动物饲料监管计划标准的制定和维护 灵活的资助模式合规性和执法扩展补充
  • 批准号:
    10599668
  • 财政年份:
    2022
  • 资助金额:
    $ 2.61万
  • 项目类别:
Funding for 2021 Survey of State Government Research and Development
2021 年州政府研究与开发调查经费
  • 批准号:
    2114762
  • 财政年份:
    2021
  • 资助金额:
    $ 2.61万
  • 项目类别:
    Contract Interagency Agreement
Development of digital learning platform, intergrating planning, teaching progression tracking and funding MIS
开发数字学习平台,整合规划、教学进度跟踪和资助管理信息系统
  • 批准号:
    54621
  • 财政年份:
    2020
  • 资助金额:
    $ 2.61万
  • 项目类别:
    Feasibility Studies
Funding for 2020 Business Research and Development Survey Operations and Related Activities
2020 年商业研究与发展调查运作及相关活动的资助
  • 批准号:
    2103021
  • 财政年份:
    2020
  • 资助金额:
    $ 2.61万
  • 项目类别:
    Contract Interagency Agreement
AWARE-EDP: Coaching and professional development to advance STEM innovation ideas and funding of underrepresented entrepreneurs and scientists
AWARE-EDP:指导和专业发展,以推进 STEM 创新理念,并为代表性不足的企业家和科学家提供资助
  • 批准号:
    1719241
  • 财政年份:
    2019
  • 资助金额:
    $ 2.61万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了