A NOVEL HIGH-CAPACITY ION TRAP-QUADRUPOLE TANDEM MASS SPECTROMETER
新型大容量离子阱四极杆串联质谱仪
基本信息
- 批准号:8361486
- 负责人:
- 金额:$ 2.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-03-01 至 2012-03-31
- 项目状态:已结题
- 来源:
- 关键词:CoupledDevelopmentFundingGenerationsGrantInternationalIonsJournalsLegal patentLinkMass Spectrum AnalysisNational Center for Research ResourcesPaperPeptidesPerformancePhosphopeptidesPrincipal InvestigatorPublishingResearchResearch InfrastructureResourcesScanningSourceTANDEMTimeUnited States National Institutes of HealthWorkcostinstrumentmacromoleculemass spectrometernovel
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
We have recently developed a novel high capacity ion trap-quadrupole mass spectrometer, which we have described previously:
A.N. Krutchinsky, H. Cohen, B.T. Chait A novel high-capacity ion trap-quadrupole tandem mass spectrometer Int J Mass Spectrom, 268 (2007) 93-105
and for which we have been granted a US patent.
We have continued this development by constructing a second generation instrument as described below:
A high-capacity ion trap coupled to a time-of-flight(TOF) mass spectrometer has been developed to carry out comprehensive linked scan analysis of all stored ions in the ion trap. The approach involves a novel tapered geometry high-capacity ion trap that can store more than 10^6 ions (range 8004000 m/z) without degrading its performance. Ions are stored and scanned out from the high-capacity ion trap as a function of m/z, collisionally fragmented and analyzed by TOF. Accurate mass analysis is achieved on both the precursor and fragments of all species ejected from the ion trap. We demonstrate the approach for comprehensive linked-scan identification of phosphopeptides in mixtures with their corresponding unphosphorylated peptides. A paper describing this work has been published:
S. Myung, H. Cohen, D. Feny¿, J.C. Padovan, A.N. Krutchinsky, B.T. Chait. "High-capacity ion trap coupled to a time-of-flight mass spectrometer for comprehensive linked scans with no scanning losses", International Journal of Mass Spectrometry 2010. In press
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SUNNIE MYUNG其他文献
SUNNIE MYUNG的其他文献
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{{ truncateString('SUNNIE MYUNG', 18)}}的其他基金
DESIGN/CONSTRUCT/TEST A NEW MASS SPECTROM FOR PROFILING PHOSPHORYLATION SITES
设计/构建/测试用于分析磷酸化位点的新质谱
- 批准号:
8361498 - 财政年份:2011
- 资助金额:
$ 2.61万 - 项目类别:
A NOVEL HIGH-CAPACITY ION TRAP-QUADRUPOLE TANDEM MASS SPECTROMETER
新型大容量离子阱四极杆串联质谱仪
- 批准号:
8169101 - 财政年份:2010
- 资助金额:
$ 2.61万 - 项目类别:
DESIGN/CONSTRUCT/TEST A NEW MASS SPECTROM FOR PROFILING PHOSPHORYLATION SITES
设计/构建/测试用于分析磷酸化位点的新质谱
- 批准号:
8169114 - 财政年份:2010
- 资助金额:
$ 2.61万 - 项目类别:
Novel Mass Spectrometer for Comprhensive No-Loss MS/MS of All Stored Ions
用于所有存储离子的全面无损 MS/MS 的新型质谱仪
- 批准号:
7806394 - 财政年份:2008
- 资助金额:
$ 2.61万 - 项目类别:
Novel Mass Spectrometer for Comprhensive No-Loss MS/MS of All Stored Ions
用于所有存储离子的全面无损 MS/MS 的新型质谱仪
- 批准号:
7405872 - 财政年份:2008
- 资助金额:
$ 2.61万 - 项目类别:
Novel Mass Spectrometer for Comprhensive No-Loss MS/MS of All Stored Ions
用于所有存储离子的全面无损 MS/MS 的新型质谱仪
- 批准号:
7555080 - 财政年份:2008
- 资助金额:
$ 2.61万 - 项目类别:
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