UAB Mental Retardation Research Center

阿拉巴马大学智力低下研究中心

• 批准号: 8141179
• 负责人: Alan Kenneth Percy
• 金额: $ 104.61万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-04 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141179
• 关键词: UAB; Mental; Retardation; Research; Center

This is the revision of a competitive renewal for a successful Mental Retardation Research Center (MRRC) in the Civitan International Research Center at the University of Alabama at Birmingham (UAB). The MRRC at DAB builds upon the University's contributions over the past three decades to the field of mental retardation and developmental disabilities. The MRRC's mission is threefold: to increase scientific knowledge about basic developmental neurobiology and factors that affect CNS development; to develop and test preventive interventions for MR/DD; and to advance understanding about effective treatment strategies to ameliorate the personal, familial, and societal consequences of MR/DD. The Center includes 62 participants comprised of 37 investigators who access research core services and another 25 clinicians and scientists who are part of the greater MRRC community but do not access research cores. Investigators from 16 basic science and clinical departments (with 51 funded or pending research projects that will use core supports) will participate. The five major research groups are: (I) Development, function and plasticity of synapses; (II) Molecular biology/genetics of nervous system development and degeneration; (III) CNS infectious diseases and neuroendocrinologic mechanisms; (IV) Diagnosis, interventions and therapies for MR/DD, and (V) Environmental effects on brain development (including behavioral interaction with parent, poverty, peers, and chemicals). An Administration and Biometry Core (Core A) provides scientific leadership, supports population-based studies on mental retardation and neurodevelopmental disabilities, provides database management and biostatistical support, sponsors center-wide scientific seminars and colloquia, encourages innovation and new multidisciplinary collaborations, actively mentors junior MRRC investigators, and oversees administrative functioning. The three research cores are: the Recombinant Technologies Core (Core B), the Developmental Neurobiology Imaging and Tissue Processing Core (Core C), and the Developmental Genomics Core (Core D). Collectively, these cores are designed to promote multidisciplinary collaboration, timely exchange of information and technology advances, attract new investigators to MR/DD research, and promote research activities with other MRRCs, as well as to increase the quality and productivity of funded research projects while demonstrating cost-effectiveness. Of high priority is the inclusion of women and individuals from underrepresented ethnic/racial groups as MRRC scientists, trainees, and participants in research projects.

这是对阿拉巴马大学伯明翰分校(UAB)奇维坦国际研究中心(MRRC)成功的智力低下研究中心(MRRC)竞争更新的修订。DAB的MRRC建立在该大学过去30年来对智力障碍和发育障碍领域的贡献的基础上。MRRC的使命有三个方面：增加有关基本发育神经生物学和影响中枢神经系统发育的因素的科学知识；开发和测试MR/DD的预防性干预措施；以及增进对有效治疗策略的了解，以改善MR/DD的个人、家庭和社会后果。该中心包括62名参与者，其中包括37名获得研究核心服务的研究人员，以及另外25名临床医生和科学家，他们是MRRC社区的一部分，但不访问研究核心。来自16个基础科学和临床部门的研究人员将参加(51个已资助或正在进行的研究项目将使用核心支持)。这五个主要研究小组是：(I)突触的发育、功能和可塑性；(Ii)神经系统发育和退化的分子生物学/遗传学；(Iii)中枢神经系统传染病和神经内分泌机制；(Iv)MR/DD的诊断、干预和治疗；以及(V)环境对大脑发育的影响(包括与父母、贫穷、同龄人和化学物质的行为互动)。管理和生物测量学核心(核心A)提供科学领导，支持关于智力障碍和神经发育障碍的基于人群的研究，提供数据库管理和生物统计学支持，赞助中心范围的科学研讨会和座谈会，鼓励创新和新的多学科合作，积极指导MRRC初级调查人员，并监督行政职能。这三个研究核心是：重组技术核心(核心B)、发育神经生物学成像和组织处理核心(核心C)和发育基因组学核心(核心D)。总体而言，这些核心旨在促进多学科合作，及时交流信息和技术进步，吸引新的研究人员参与MR/DD研究，促进与其他MRRC的研究活动，并在展示成本效益的同时，提高受资助研究项目的质量和生产率。当务之急是让妇女和来自代表性不足的族裔/种族群体的个人成为MRRC的科学家、受训者和研究项目的参与者。