Continued development and maintenance of WebLogo3:Sequence logos redrawn

描述(由申请人提供)：继续开发和维护WebLogo 3：序列标识重新绘制G.E.Crooks WebLogo是用于分析DNA或蛋白质序列的计算工具。WebLogo生成序列徽标，这是一组氨基酸或核酸序列中统计模式的紧凑图形表示。每个徽标由一堆符号组成，序列中的每个位置对应一堆符号。堆叠的总高度表示该位置的序列保守性，而堆叠内符号的高度表示每个氨基酸或核酸在该位置的相对频率。序列标识提供了对例如DNA序列中的蛋白质结合部位的简明且易于理解的描述。WebLogo已被700多种出版物使用。这笔赠款将使WebLogo能够继续得到支持和维护。 公共卫生相关性：继续开发和维护WebLogo 3：重新绘制的序列标识G.E.骗子WebLogo帮助生物学家了解人类和人类病原体的基因组和分子组成。

DESCRIPTION (provided by applicant): Continued development and maintenance of WebLogo 3: Sequence logos redrawn G.E. Crooks WebLogo is a computational tool for the analysis of DNA or protein sequences. WebLogo generates sequence logos, compact graphical representations of the statistical patterns in a collection of amino acid or nucleic acid sequences. Each logo consists of stacks of symbols, one stack for each position in the sequence. The overall height of the stack indicates the sequence conservation at that position, while the height of symbols within the stack indicates the relative frequency of each amino or nucleic acid at that position. Sequence logos provide concise and readily comprehendible description of, for example, protein binding sites within a DNA sequence. WebLogo has been used in over 700 publications. This grant will enable the continued support and maintenance of WebLogo. PUBLIC HEALTH RELEVANCE: Continued development and maintenance of WebLogo 3: Sequence logos redrawn G.E. Crooks WebLogo aids biologists in understanding the genome and molecular components of humans and human pathogens.