Continued development and maintenance of WebLogo3:Sequence logos redrawn

描述（由申请人提供）：继续开发和维护WebLogo 3：重新绘制的序列标识（G.E.）Crooks WebLogo是一种用于分析DNA或蛋白质序列的计算工具。WebLogo生成序列标识，这是氨基酸或核酸序列集合中统计模式的紧凑图形表示。每个徽标都由符号堆栈组成，序列中的每个位置都有一个堆栈。堆叠的总高度指示该位置处的序列保守性，而堆叠内的符号的高度指示该位置处的每个氨基酸或核酸的相对频率。序列标识提供了对例如DNA序列内的蛋白质结合位点的简明且容易理解的描述。WebLogo已在700多份出版物中使用。这笔赠款将使继续支持和维护WebLogo。 公共卫生相关性：继续开发和维护WebLogo 3：重新绘制的序列标识Crooks WebLogo帮助生物学家了解人类和人类病原体的基因组和分子组成。

DESCRIPTION (provided by applicant): Continued development and maintenance of WebLogo 3: Sequence logos redrawn G.E. Crooks WebLogo is a computational tool for the analysis of DNA or protein sequences. WebLogo generates sequence logos, compact graphical representations of the statistical patterns in a collection of amino acid or nucleic acid sequences. Each logo consists of stacks of symbols, one stack for each position in the sequence. The overall height of the stack indicates the sequence conservation at that position, while the height of symbols within the stack indicates the relative frequency of each amino or nucleic acid at that position. Sequence logos provide concise and readily comprehendible description of, for example, protein binding sites within a DNA sequence. WebLogo has been used in over 700 publications. This grant will enable the continued support and maintenance of WebLogo. PUBLIC HEALTH RELEVANCE: Continued development and maintenance of WebLogo 3: Sequence logos redrawn G.E. Crooks WebLogo aids biologists in understanding the genome and molecular components of humans and human pathogens.