Genetic Network Linking Immunity to Energetic Stress, Metabolism and Reproduction

点击翻译按钮获取中文摘要

Program Director/Principal Investigator (Last, First, Middle): Lazzaro, Brian P. 1R01 AI083932-01 GENETIC NETWORK LINKING IMMUNITY TO ENERGETIC STRESS, METABOLISM, AND REPRODUCTION ABSTRACT Resistance to infection is determined by immune system activity and the overall physiological condition of the host. This project will determine how the seemingly disparate physiological processes of immunity, metabolism and reproduction are genetically linked to determine resistance to infection in the genetic model system Drosophila melanogaster. Although Drosophila is an insect, its immune and metabolic processes are sufficiently similar to those of vertebrates that it can serve as an informative model for human clinical biology. Drosophila is also an important model for other insects, including agricultural pests and disease vectors of