Host-Microbe Interactions that Determine Host Traits and Disease

决定宿主特征和疾病的宿主-微生物相互作用

• 批准号: 10618151
• 负责人: Brian Lazzaro
• 金额: $ 38.75万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618151
• 关键词: Disease; host-microbe interactions; trait

Project Summary Molecular interactions between hosts and microbes have substantial impact on host physiology, development, and disease symptomology. This training program will support five postdoctoral scholars to collaborate with faculty-led research groups at Cornell in the study of how molecular interactions between microbes (bacteria, fungi and viruses) and their animal and plant hosts manifest as major traits in the host. Eligible trainees will be recruited from top Ph.D. programs in the nation and world, with a concerted emphasis on recruitment of trainees who affiliate with groups that are historically underrepresented in biological research. Trainees will work in collaboration two or more trainer labs but will have considerable research independence and a discretionary research allowance. All trainees will have intellectual ownership over their projects and will be allowed to carry their postdoctoral research into subsequent independent positions if they so desire. The role of the training mentors will be to provide the necessary infrastructure and resources to support the research, and to cultivate trainee development and preparedness for independent research-related careers in academia, industry, or government. Training will be coordinated through the Cornell Institute of Host-Microbe Interactions and Disease (CIHMID) and will include a substantial component of professional development in addition to the research training. The research component will emphasize specialized training using advanced methodologies in a highly interdisciplinary environment, exploiting comparison across diverse biological systems to maximize intellectual breadth, creativity, and insight. The professional development will include an array of activities and workshops designed to help trainees secure and be successful in the subsequent position of their choice. Each trainee will work with a tailored mentoring committee to create a personalized Individual Development Plan (IDP) that will include annual objectives and benchmarks for both the research and professional development components.

项目摘要 宿主与微生物之间的分子相互作用对宿主的生理有着重要的影响， 发展和疾病生物学。该培训计划将支持五名博士后学者， 与康奈尔大学的教师领导的研究小组合作，研究分子之间的相互作用 微生物（细菌、真菌和病毒）及其动植物宿主表现为宿主的主要特征。 符合条件的学员将从顶级博士中招募。在国家和世界的计划，与协调一致的 * 强调征聘属于历来在联合国代表性不足的群体的受训人员， 生物学研究学员将在两个或更多的培训师实验室合作，但将有相当大的 研究独立性和酌情研究津贴。所有学员将有知识 他们的项目的所有权，并将被允许进行他们的博士后研究到随后的 独立的位置，如果他们愿意。培训导师的作用将是提供必要的 基础设施和资源，以支持研究，并培养学员的发展， 为学术界，工业界或政府的独立研究相关职业做好准备。 培训将通过康奈尔宿主-微生物相互作用和疾病研究所进行协调 （CIHMID），并将包括专业发展的实质性组成部分，除了研究 训练研究部分将强调采用先进方法的专门培训， 高度跨学科的环境，利用不同生物系统之间的比较， 智力广度、创造力和洞察力。专业发展将包括一系列活动 和讲习班，旨在帮助学员获得并成功地在随后的立场， 选择每个学员将与量身定制的指导委员会合作，以创建个性化的个人 发展计划（IDP），将包括年度目标和基准的研究和 专业发展的组成部分。

项目成果

Comparison of commercially available, rapid, point-of-care C-reactive protein assays among children with febrile illness in southwestern Uganda.

• DOI: 10.1371/journal.pgph.0002727
• 发表时间: 2024
• 期刊: PLOS global public health

Assembling microbial communities: a genomic analysis of a natural experiment in neotropical bamboo internodes.

• DOI: 10.7717/peerj.13958
• 发表时间: 2022
• 期刊: PEERJ
• 影响因子: 2.7
• 作者: Ahluwalia, Sonia;Holmes, Iris;von May, Rudolf;Rabosky, Daniel L.;Rabosky, Alison R. Davis
• 通讯作者: Rabosky, Alison R. Davis

A low-cost genomics workflow enables isolate screening and strain-level analyses within microbiomes.

低成本的基因组工作流程可实现微生物组中的分离筛选和应变水平分析。

• DOI: 10.1186/s13059-022-02777-w
• 发表时间: 2022-10-12
• 期刊: Genome biology
• 影响因子: 12.3

Steroid hormone regulation of innate immunity in Drosophila melanogaster.

• DOI: 10.1371/journal.pgen.1010782
• 发表时间: 2023-06
• 期刊: PLoS genetics
• 影响因子: 4.5

Genetic mechanisms and correlational selection structure trait variation in a coral snake mimic.

珊瑚蛇拟态体的遗传机制和相关选择结构性状变异。

• DOI: 10.1098/rspb.2021.0003
• 发表时间: 2021
• 期刊: Proceedings. Biological sciences
• 作者: Curlis,JohnDavid;DavisRabosky,AlisonR;Holmes,IrisA;Renney,TimothyJ;Cox,ChristianL
• 通讯作者: Cox,ChristianL