Neural Mechanisms Associated with Nicotine Addiction and Obesity Co-Morbidities

与尼古丁成瘾和肥胖合并症相关的神经机制

• 批准号: 8063825
• 负责人: Laura E Martin
• 金额: $ 3.75万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8063825
• 关键词: Address; Alcohol or Other Drugs use; Alcohols; Area; Behavior; Behavior Control; Behavioral; Body Weight decreased; Body mass index; Brain; Brain region; Cause of Death; Cigarette Smoker; Comorbidity; Cues; Development; Food; Functional Magnetic Resonance Imaging; Goals; Hyperphagia; Image; Individual; Lead; Morbid Obesity; Neural Network Simulation; Nicotine; Nicotine Dependence; Obesity; Pattern; Population; Process; Public Health; Regulation; Research; Research Project Grants; Rewards; Scanning; Smoke; Smoker; Smoking; System; Tobacco; Tobacco use; United States; Weight; Work; design; effective intervention; neuroimaging; neuromechanism; non-smoking; relating to nervous system; response; reward processing; smoking cessation; success; treatment program

DESCRIPTION (provided by applicant): Tobacco use and obesity are the top preventable causes of death in the United States. Behavioral studies show that obese smokers may be less sensitive to nicotine reward compared to healthy weight smokers. Neuroimaging studies demonstrate that smokers are hyper-responsive to smoking cues and obese groups are hyper-responsive to food cues. There is significant overlap between the brain regions involved in reward processing and behavioral control. These findings have added support to shared neural network models of smoking, overeating, and other behaviors requiring regulation of impulses. However, little is known about how these reward areas of the brain respond to food and smoking images when an individual is both a smoker and obese. The long term goal of this research is to increase our understanding of how the neural systems of reward differentially respond in the case of co-morbid obesity and nicotine addiction, which will inform smoking cessation and weight management treatment programs designed for the specific needs of obese smokers. The proposed research project will employ functional magnetic resonance imaging (fMRI) to examine the neural systems of reward while obese and healthy weight smokers view food and smoking images in the scanner. We hypothesize that obese smokers will show increased responses to food cues and decreased responses to smoking cues compared to healthy weight smokers. We will scan healthy weight smokers and obese smokers while they view smoking cues and food cues. The project will address the following Specific Aims: 1. Characterize brain systems underlying cue processing of a preferred substance (food or smoking images) in a combined group of smokers (regardless of weight). 2. Identify brain responses associated with co-morbid obesity and nicotine addiction by examining fMRI activation differences between groups of healthy weight and obese smokers. PUBLIC HEALTH RELEVANCE: Results of this work are highly significant to public health and could lead to a better understanding of how co- morbidities of obesity and nicotine addiction relate to brain activations in response to food and smoking images. Findings from this study will have significant implications for understanding mechanisms of obesity and nicotine addiction, and the effects of co-morbidities on brain function in obese and healthy weight smokers. Findings may eventually lead to more effective interventions.

描述（由申请人提供）：烟草使用和肥胖是美国最主要的可预防死亡原因。行为研究表明，与健康体重的吸烟者相比，肥胖吸烟者对尼古丁奖励的敏感性可能较低。神经影像学研究表明，吸烟者对吸烟线索反应过度，肥胖人群对食物线索反应过度。大脑中负责奖励处理和行为控制的区域有很大的重叠。这些发现为吸烟、暴饮暴食和其他需要调节冲动的行为的共享神经网络模型提供了支持。然而，当一个人既是吸烟者又是肥胖者时，大脑的这些奖励区域如何对食物和吸烟图像做出反应，人们知之甚少。这项研究的长期目标是增加我们对奖励神经系统在肥胖和尼古丁成瘾并存的情况下如何做出不同反应的理解，这将为针对肥胖吸烟者特定需求而设计的戒烟和体重管理治疗计划提供信息。拟议中的研究项目将采用功能性磁共振成像（fMRI）来检查奖励的神经系统，而肥胖和健康体重的吸烟者在扫描仪中查看食物和吸烟图像。我们假设肥胖吸烟者对食物的反应比健康体重的吸烟者更强，对吸烟的反应比健康体重的吸烟者更弱。我们将扫描健康体重的吸烟者和肥胖的吸烟者，同时他们查看吸烟线索和食物线索。该项目将解决以下具体目标：1。描述一组吸烟者（无论体重如何）对偏好物质（食物或吸烟图像）的潜在线索处理的大脑系统。2.通过检查健康体重组和肥胖吸烟者组之间的fMRI激活差异，确定与共病肥胖和尼古丁成瘾相关的大脑反应。 公共卫生相关性：这项工作的结果对公共卫生具有重要意义，并可能导致更好地了解肥胖和尼古丁成瘾的共病如何与大脑激活对食物和吸烟图像的反应有关。这项研究的结果将对理解肥胖和尼古丁成瘾的机制以及肥胖和健康体重吸烟者的合并症对脑功能的影响具有重要意义。研究结果最终可能会导致更有效的干预措施。