Effects of Marijuana on Driving: a Standardized Assessment

描述（由申请人提供）：吸食大麻后醉酒驾驶是一个严重的问题。几乎一半的12年级学生尝试过大麻，四分之一的人在大麻的影响下开车目前还没有一种简单的标准化评估方法，可以通过最少的培训来进行管理和分析，以测试大麻中毒造成的损害。本研究将评估两项任务的敏感性，这两项任务可以在最少的训练和时间内进行，与大麻剂量依赖性效应的简短模拟驱动（安慰剂，200微克/千克和300微克/千克）进行比较。将招募50名健康的偶尔吸食大麻的人参加三次访问，每次访问期间，他们将完成车道变化测试、注意力评估和多次间隔的模拟驾驶。据推测，所有的任务都会在吸食大麻后立即显示出剂量依赖性的性能损害，并且这种损害会随着时间的推移而减弱。进一步假设Lane Change Test和the Attention Assessment可以提供快速简便的损伤汇总统计，适合用于大麻中毒的工作场所评估。

DESCRIPTION (provided by applicant): Driving while intoxicated by marijuana is a serious concern. Almost half of 12th graders have tried marijuana and 1 in 4 have driven under its influence.1 Currently there is no brief standardized assessment that can be administered and analyzed with minimal training to test for impairment from marijuana intoxication. This study will evaluate the sensitivity of two tasks that can be administered with minimal training and time in comparison with an abbreviated simulated drive on the dose-dependent effects of marijuana (placebo, 200 mcg/kg and 300 mcg/kg). Fifty healthy, occasional users of marijuana will be recruited to participate in three visits each during which they will complete the Lane Change Test, The Attention Assessment and a simulated drive at multiple time intervals. It is hypothesized that all tasks will show a dose dependent impairment in performance immediately following marijuana use and that impairment will diminish over time. It is further hypothesized that the Lane Change Test and The Attention Assessment, which provide quick and easy summary statistics of impairment, will be suitable for use in workplace assessment of marijuana intoxication. PUBLIC HEALTH RELEVANCE: Driving while intoxicated by marijuana is a serious public health concern as almost half of 12th graders have tried marijuana and 1 in 4 have driven under its influence. This study will evaluate the sensitivity of the Lane Change Task and The Attention Assessment in comparison with simulated driving on the ability to detect marijuana impairment at multiple time points and doses. Identification of fast, reliable, assessments that can be conducted with minimal training will aid in the detection of driving impairment due to marijuana and potentially decrease its prevalence, thereby saving lives.