Simulated Driving Under the Influence of Marijuana: an fMRI Study

大麻影响下的模拟驾驶:功能磁共振成像研究

基本信息

  • 批准号:
    7989705
  • 负责人:
  • 金额:
    $ 25.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-03-01 至 2013-02-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Despite a widespread belief that marijuana (MJ) impairs driving, the negative impact of acute MJ use on driving performance has been elusive and difficult to replicate. Most driving studies use daylight environments and dry road conditions. Driving after dark when visibility is diminished and/or on icy/snowy roads may further tax driving skills to reveal important deficits. Use of this more challenging, yet realistic scenario may provide a more sensitive, reproducible measure of driving impairment. Functional magnetic resonance imaging (fMRI) will be used during these novel simulated driving scenarios to elucidate the impact of marijuana on known driving neural circuitry. Occasional marijuana users (n=24) will participate in this within-subject, repeated measures design. In a randomized order and in separate testing sessions, participants will receive a placebo, 200 mc/kg, or 300 mc/kg vaporized marijuana via a paced inhalation protocol. Participants will drive in four simulated environments: daylight with dry roads, daylight with icy roads, nighttime with dry roads, and nighttime with icy roads. Under normal road conditions, participants under the influence of marijuana are expected to show a compensatory decrease in speed. Healthy, non-intoxicated volunteers usually slow down in both icy and nighttime conditions. We hypothesize that MJ participants will fail to show such slowing under sub-optimal driving conditions. We further hypothesize brain regions rich in cannabinoid receptors and involved in procedural learning (e.g., the cerebellum) will show altered neural connectivity, while regions with few cannabinoid receptors (e.g., primary visual area) or areas with less involvement in procedural learning (e.g., amygdala) will remain unaffected. Identification of replicable driving scenarios will be useful in future research establishing a behavioral threshold at which driving becomes impaired by marijuana. Identification of the driving neural circuitry altered by marijuana intoxication will aid in understanding whether the impact of marijuana on driving is primarily due to decision making, perceptual distortions, motor coordination, or procedural skill deficits. Impaired neural circuitry involved in decision-making and judgment will have more serious public health consequences as persons under the influence of marijuana may be more likely to continue driving despite intoxication. PUBLIC HEALTH RELEVANCE: Despite a widespread belief that it is harmful, the negative impact of acute marijuana use on driving performance has been difficult to document in repeatable research studies. Most studies, however, evaluate driving during daylight hours with dry road conditions. Driving after dark when visibility is diminished and/or on icy, slippery roads as proposed in this study may provide a more sensitive, reproducible measure of driving impairment under the influence of marijuana. Functional magnetic resonance imaging will provide further insight into how marijuana impairs the neural circuitry involved in driving.
描述(由申请人提供):尽管人们普遍认为大麻(MJ)会损害驾驶能力,但急性使用MJ对驾驶表现的负面影响一直难以捉摸,也难以复制。大多数驾驶研究使用日光环境和干燥的道路条件。在天黑后能见度较低及/或在结冰/下雪的道路上驾驶,可能会进一步加重驾驶技巧的负担,从而暴露出重要的缺陷。使用这种更具挑战性但更现实的场景可以提供更敏感、可重复的驾驶损伤测量方法。功能磁共振成像(fMRI)将在这些新的模拟驾驶场景中使用,以阐明大麻对已知驾驶神经回路的影响。偶尔吸食大麻的人(n=24)将参与这个主题内重复测量设计。在随机顺序和单独的测试阶段,参与者将通过有节奏吸入方案接受安慰剂,200 mc/kg或300 mc/kg汽化大麻。参与者将在四种模拟环境中驾驶:白天干燥的道路、白天结冰的道路、夜间干燥的道路和夜间结冰的道路。在正常路况下,受大麻影响的参与者预计会表现出速度的代偿性降低。健康的、未醉酒的志愿者通常会在结冰和夜间的条件下放慢速度。我们假设MJ参与者在次优驾驶条件下不会表现出这种减速。我们进一步假设富含大麻素受体并参与程序学习的大脑区域(如小脑)将显示出神经连通性的改变,而大麻素受体较少的区域(如初级视觉区)或较少参与程序学习的区域(如杏仁核)将不受影响。识别可复制的驾驶场景将有助于未来的研究,建立一个行为阈值,使驾驶受到大麻的损害。识别大麻中毒改变的驾驶神经回路将有助于理解大麻对驾驶的影响主要是由于决策、知觉扭曲、运动协调还是程序技能缺陷。参与决策和判断的神经回路受损将对公共健康造成更严重的后果,因为受大麻影响的人更有可能在醉酒的情况下继续开车。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Beth Marie Anderson其他文献

Beth Marie Anderson的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Beth Marie Anderson', 18)}}的其他基金

Effects of Marijuana on Driving: a Standardized Assessment
大麻对驾驶的影响:标准化评估
  • 批准号:
    8138608
  • 财政年份:
    2010
  • 资助金额:
    $ 25.51万
  • 项目类别:
Effects of Marijuana on Driving: a Standardized Assessment
大麻对驾驶的影响:标准化评估
  • 批准号:
    8061184
  • 财政年份:
    2010
  • 资助金额:
    $ 25.51万
  • 项目类别:
DOES GENDER INFLUENCE THE EFFECTS OF ACUTE MARIJUANA USE ON DRIVING?
性别是否会影响急性吸食大麻对驾驶的影响?
  • 批准号:
    7604852
  • 财政年份:
    2007
  • 资助金额:
    $ 25.51万
  • 项目类别:
DOES GENDER INFLUENCE THE EFFECTS OF ACUTE MARIJUANA USE ON DRIVING?
性别是否会影响急性吸食大麻对驾驶的影响?
  • 批准号:
    7377067
  • 财政年份:
    2006
  • 资助金额:
    $ 25.51万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 25.51万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了