DOES GENDER INFLUENCE THE EFFECTS OF ACUTE MARIJUANA USE ON DRIVING?

性别是否会影响急性吸食大麻对驾驶的影响？

• 批准号: 7604852
• 负责人: Beth Marie Anderson
• 金额: $ 0.19万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604852
• 关键词: Activities of Daily Living; Acute; Affect; Area; Attention; Automobile Driving; Cognition; Computer Retrieval of Information on Scientific Projects Database; Country; Development; Dose; Female; Funding; Gender; Grant; Impairment; Institution; Marijuana; Memory; Motor; Perception; Performance; Placebos; Process; Protocols documentation; Research; Research Personnel; Resources; Sex Characteristics; Side; Simulate; Smoking; Source; Testing; Tetrahydrocannabinol; United States National Institutes of Health; Visuospatial; Woman; Work; executive function; male; sobriety

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving is a key activity of daily living in many countries around the world. Safe driving requires the coordination of several ongoing processes including attention, perception, memory, and executive functions. Impairment of any of these capacities following marijuana use may cause unsafe driving. Several studies have been performed examining the effects of acute marijuana use on driving in both simulated and on-the-road settings. While these studies have demonstrated that acute marijuana use affects a driver's ability to successfully complete driving tasks, few have explored which components of driver error are most vulnerable to the effects of marijuana. An understanding of error types made under the influence of marijuana is critical in development of road-side sobriety tests for marijuana impairment. Prior studies have shown gender liability in females to the effects of marijuana use on visuospatial perception and motor performance. While these findings implicate potential gender differences in driving performance following acute marijuana use, little work has been performed in this area. We propose to examine the influence of gender on driving performance and cognition following acute marijuana use. Fifthy male and 50 female occasional marijuana users will participate in this project. Half will receive a moderate dose of marijuana (~20 mg tetrahydrocannabinol) and half will receive a placebo via a paced smoking protocol. We hypothesize acute marijuana use will compound errors made during simulated driving and women will be more vulnerable to these effects.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 驾驶是世界上许多国家日常生活中的一项重要活动。 安全驾驶需要协调几个正在进行的过程，包括注意力，感知，记忆和执行功能。 使用大麻后这些能力的任何损害都可能导致不安全驾驶。 已经进行了几项研究，研究急性大麻使用对模拟和道路环境中驾驶的影响。 虽然这些研究表明，急性大麻使用影响司机成功完成驾驶任务的能力，但很少有人探讨司机错误的哪些组成部分最容易受到大麻的影响。 了解在大麻影响下所犯的错误类型对于开发大麻损害的路边清醒度测试至关重要。 先前的研究表明，女性对大麻使用对视觉空间感知和运动表现的影响存在性别倾向。 虽然这些发现暗示了急性大麻使用后驾驶性能的潜在性别差异，但在这方面几乎没有进行过研究。 我们建议研究性别对驾驶性能和认知的影响，急性大麻使用。 第五名男性和50名女性偶尔吸食大麻者将参加这个项目。 一半人将接受中等剂量的大麻（约20毫克四氢大麻酚），另一半人将通过起搏吸烟协议接受安慰剂。 我们假设急性大麻使用会加剧模拟驾驶过程中的错误，女性更容易受到这些影响。