2010 Signalling by Adhesion Receptors Gordon Research Conference

描述（由申请人提供）：该提案要求部分支持戈登研究会议（GRC）“细胞粘附受体的信号传导”，以及相关的戈登-凯南研究生研究研讨会（GK-GRS）“细胞粘附受体在细胞信号传导途径的十字路口：新的方向和方法”。会议的广泛和长期目标是增加我们对细胞如何感知和响应来自细胞外基质和邻近细胞的信号的理解，以及它们如何将这些信号转化为细胞在正常和疾病状态下的分化，细胞运动和细胞间相互作用中的细胞决策变化。这些问题的答案对于理解胚胎发生和转移性癌症等疾病期间细胞运动和相互作用的机制至关重要。会议的具体目标是召集约20名研究生参加为期一天半的GK-GRS会议，邀请22名研究生参加为期五天的主要GRC会议，并从提交的材料中选出16名演讲者。会议提供了一个独特的论坛，比较，对比和整合来自粘附受体的多样性和细胞机制的最新研究信息，将它们与细胞内信号通路和细胞骨架联系起来。这一应用的意义在于，细胞粘附受体信号传导的GRC和相关的GK-GRS独特地定位于细胞粘附，信号传导和命运的联系，因此吸引了来自不同学科的国际领导者和学生，包括对3-D组织组织和疾病过程感兴趣的发育生物学家和临床医生，对细胞机制感兴趣的细胞生物学家和生物化学家，以及对测量机械力和为组织工程制造细胞环境感兴趣的生物药理学家和生物工程师。具有这些不同研究兴趣和专门知识的科学家之间的交流和思想的相互促进，大大有助于会议在这些领域产生影响。该应用程序的健康相关性是理解细胞粘附受体的信号传导，机制和功能及其在正常人类发育和血液，免疫系统，血管系统和癌症疾病状态中的作用之间的紧密联系。 该应用程序的健康相关性是，本次会议将提供一个独特的论坛，讨论理解细胞粘附受体的信号传导，机制和功能及其在正常人类发育和血液，免疫系统，血管系统和癌症疾病状态中的作用之间的密切联系。此外，会议还强调了在正常发育和疾病模型中成像细胞迁移的创新方法，以及制造3D细胞环境以询问细胞活动和开发组织工程平台。这些讨论将使与会者集中在理解正常人类发育和疾病中细胞粘附和迁移的重要问题上。

DESCRIPTION (provided by applicant): This proposal requests partial support for the Gordon Research Conference (GRC) "Signaling by Cell Adhesion Receptors", and an associated Gordon-Kenan Graduate Research Seminar (GK-GRS) "Cell Adhesion Receptors at the Cross-Roads of Cell Signaling Pathways: New Directions and Approaches". The broad and long-term goals of the Conferences are to increase our understanding of how cells sense and respond to signals from the extracellular matrix and neighboring cells, and how they convert those signals into changes in cell decision making in differentiation, cell movement, and cell-cell interactions in normal and disease states. Answers to these problems are central to understanding the mechanics of cell movements and interactions during embryogenesis and diseases such as metastatic cancer. The specific aims of the meetings are to convene ~20 graduate students for the GK-GRS for a one and half day meeting, and 22 invited and 16 speakers chosen from submissions and a total of ~170 participants for the main five day GRC. The Conference provides a unique forum to compare, contrast and integrate information from the latest studies of a diversity of adhesion receptors and the cellular mechanisms linking them to intracellular signaling pathways and the cytoskeleton. The significance of this application is that the GRC on Signaling by Cell Adhesion Receptors, and the associated GK-GRS, is uniquely positioned at the nexus of cell adhesion, signaling and fate, and therefore attracts international leaders and students from a diversity of disciplines including developmental biologists and clinicians interested in 3-D tissue organization and disease processes, cell biologists and biochemists interested in cellular mechanisms, and biophysicist and bio-engineers interested in measuring mechanical forces and fabricating cell environments for tissue engineering. The crosstalk and cross-fertilization of ideas between scientists with these different research interests and expertise contributes greatly to the impact of the Conference across these fields. The health relatedness of this application is the strong link between understanding the signaling, mechanics and function of cell adhesion receptors and their roles in normal human development and disease states of the blood, immune system, vasculature, and cancer. The health relatedness of this application is that this meeting will provide a unique forum for discussion of the strong link between understanding the signaling, mechanics and function of cell adhesion receptors and their roles in normal human development and disease states of the blood, immune system, vasculature, and cancer. In addition, the meeting highlights innovative approaches to imaging cell migration in normal development and disease models, and in the fabrication of 3-D cellular environments to interrogate cellular activities and develop tissue engineering platforms. These discussions will focus participants on important problems in understanding cell adhesion and migration in normal human development and disease.