2012 Signaling by Adhesion Receptor Gordon Research Conference and Frontiers in A

2012 年粘附受体信号传递戈登研究会议和前沿

• 批准号: 8318467
• 负责人: Martin A Schwartz
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-06 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318467
• 关键词: Adhesions; Area; Biochemistry; Biological Process; Biology; Biophysics; Cadherins; Cardiovascular Diseases; Cell Adhesion; Cells; Cellular biology; Collaborations; Congenital Abnormality; Cytoskeleton; Data; Development; Developmental Biology; Differentiation and Growth; Discipline; Disease; Family; Feedback; Fertilization; Fostering; Funding; Funding Applicant; Goals; Guanosine Triphosphate Phosphohydrolases; Health; Human; Integrins; Knowledge; Lead; Life; Malignant Neoplasms; Medical Students; Molecular; Nature; Oral; Organism; Participant; Pathology; Pathway interactions; Physiology; Postdoctoral Fellow; Receptor Signaling; Request for Proposals; Research; Research Personnel; Running; Scientist; Signal Pathway; Signal Transduction; Students; System; Systems Biology; Tissues; Training; Whole Organism; Work; abstracting; adhesion receptor; base; cell motility; college; data sharing; design; experience; frontier; graduate student; improved; insight; meetings; multidisciplinary; planetary Atmosphere; posters; receptor function; rho; symposium

DESCRIPTION (provided by applicant): Funds are requested to support the Gordon Research Conference (GRC) on "Signaling by Adhesion Receptors" to be held June 24 - 29, 2012 at Colby College, Waterville, ME. This meeting will be held in conjunction with a Gordon Research Seminar (GRS) entitled "Frontiers in Adhesion and Signaling", June 23- 24. The GRC will cover a range of topics including signaling by integrins to cytoskeletal, growth, differentiation and developmental pathways, signaling by cadherins to cytoskeletal, growth, differentiation and developmental pathways, mechanotransduction through integrins and cadherins, the Hippo/YAP pathway, systems biology approaches to signaling by cell adhesion receptors, and signaling by other adhesion receptors. The meeting will bring together speakers, discussants and participants who represent a wide range of disciplines, approaches and systems. The small size of the conference and the informal atmosphere will facilitate discussion and interactions. The accompanying GRS will provide a forum for students and postdoctoral fellows to network and share data, and will greatly strengthen the educational component. Major advances in our understanding of regulatory functions of these receptors, especially new insights into fundamental biophysical mechanisms of signaling and mechanotransduction, and the connection to development and disease make this a particularly timely meeting. PUBLIC HEALTH RELEVANCE: The main goal of this meeting is to accelerate progress by researchers who are studying the biophysics, biochemistry, cell biology, developmental biology and whole organism physiology/pathology of signaling by integrins, and cadherins and other adhesion receptors. Bringing together investigators from these different areas has the potential to catalyze major progress through both cross fertilization, in which ideas and approaches from one field can be applied to the other, and through generalization, in which broad principles become evident. Deeper understanding of the fundamental molecular, cellular and organismal basis for signaling by cell adhesion receptors will lead to improved understanding of birth defects, cardiovascular disease, and cancer among other major problems in human health.

说明（由申请人提供）： 请求资金支持将于 2012 年 6 月 24 日至 29 日在缅因州沃特维尔科尔比学院举行的关于“粘附受体信号传导”的戈登研究会议 (GRC)。本次会议将于 6 月 23 日至 24 日与题为“粘附和信号传导前沿”的戈登研究研讨会 (GRS) 同期举行。GRC 将涵盖一系列主题，包括整合素向细胞骨架发出的信号、生长、分化和发育途径、钙粘蛋白向细胞骨架发出的信号、生长、分化和发育途径、通过整合素和钙粘蛋白进行的机械转导、 Hippo/YAP 途径是细胞粘附受体信号传导和其他粘附受体信号传导的系统生物学方法。会议将汇集代表广泛学科、方法和系统的演讲者、讨论者和参与者。会议规模较小，气氛轻松，有利于讨论和互动。随附的 GRS 将为学生和博士后研究员提供一个交流和共享数据的论坛，并将大大加强教育内容。我们对这些受体调节功能的理解取得了重大进展，特别是对信号传导和机械转导的基本生物物理机制以及与发育和疾病的联系的新见解，使这次会议变得特别及时。 公共健康相关性：本次会议的主要目标是加快研究整合素、钙粘蛋白和其他粘附受体信号传导的生物物理学、生物化学、细胞生物学、发育生物学和整个生物体生理学/病理学的研究人员的进展。将来自这些不同领域的研究人员聚集在一起，有可能通过交叉施肥（其中一个领域的想法和方法可以应用于另一领域）和通过泛化（其中广泛的原则变得明显）来催化重大进展。更深入地了解细胞粘附受体信号传导的分子、细胞和有机体基础将有助于更好地了解出生缺陷、心血管疾病和癌症以及人类健康中的其他主要问题。