2012 Signaling by Adhesion Receptor Gordon Research Conference and Frontiers in A

2012 年粘附受体信号传递戈登研究会议和前沿

• 批准号: 8318467
• 负责人: Martin A Schwartz
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-06 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318467
• 关键词: Adhesions; Area; Biochemistry; Biological Process; Biology; Biophysics; Cadherins; Cardiovascular Diseases; Cell Adhesion; Cells; Cellular biology; Collaborations; Congenital Abnormality; Cytoskeleton; Data; Development; Developmental Biology; Differentiation and Growth; Discipline; Disease; Family; Feedback; Fertilization; Fostering; Funding; Funding Applicant; Goals; Guanosine Triphosphate Phosphohydrolases; Health; Human; Integrins; Knowledge; Lead; Life; Malignant Neoplasms; Medical Students; Molecular; Nature; Oral; Organism; Participant; Pathology; Pathway interactions; Physiology; Postdoctoral Fellow; Receptor Signaling; Request for Proposals; Research; Research Personnel; Running; Scientist; Signal Pathway; Signal Transduction; Students; System; Systems Biology; Tissues; Training; Whole Organism; Work; abstracting; adhesion receptor; base; cell motility; college; data sharing; design; experience; frontier; graduate student; improved; insight; meetings; multidisciplinary; planetary Atmosphere; posters; receptor function; rho; symposium

DESCRIPTION (provided by applicant): Funds are requested to support the Gordon Research Conference (GRC) on "Signaling by Adhesion Receptors" to be held June 24 - 29, 2012 at Colby College, Waterville, ME. This meeting will be held in conjunction with a Gordon Research Seminar (GRS) entitled "Frontiers in Adhesion and Signaling", June 23- 24. The GRC will cover a range of topics including signaling by integrins to cytoskeletal, growth, differentiation and developmental pathways, signaling by cadherins to cytoskeletal, growth, differentiation and developmental pathways, mechanotransduction through integrins and cadherins, the Hippo/YAP pathway, systems biology approaches to signaling by cell adhesion receptors, and signaling by other adhesion receptors. The meeting will bring together speakers, discussants and participants who represent a wide range of disciplines, approaches and systems. The small size of the conference and the informal atmosphere will facilitate discussion and interactions. The accompanying GRS will provide a forum for students and postdoctoral fellows to network and share data, and will greatly strengthen the educational component. Major advances in our understanding of regulatory functions of these receptors, especially new insights into fundamental biophysical mechanisms of signaling and mechanotransduction, and the connection to development and disease make this a particularly timely meeting. PUBLIC HEALTH RELEVANCE: The main goal of this meeting is to accelerate progress by researchers who are studying the biophysics, biochemistry, cell biology, developmental biology and whole organism physiology/pathology of signaling by integrins, and cadherins and other adhesion receptors. Bringing together investigators from these different areas has the potential to catalyze major progress through both cross fertilization, in which ideas and approaches from one field can be applied to the other, and through generalization, in which broad principles become evident. Deeper understanding of the fundamental molecular, cellular and organismal basis for signaling by cell adhesion receptors will lead to improved understanding of birth defects, cardiovascular disease, and cancer among other major problems in human health.

描述(由申请者提供)：申请资助将于2012年6月24-29日在密歇根州沃特维尔的科尔比学院举行的戈登研究会议(GRC)，主题为“通过黏附受体传递信号”。本次会议将与戈登研究研讨会(GRS)同时举行，该研讨会将于6月23-24日举行，题为“粘合和信号方面的前沿”。GRC将涵盖一系列主题，包括整合素到细胞骨架的信号传递、生长、分化和发育途径、钙粘附素到细胞骨架的信号传递、生长、分化和发育途径、整合素和钙粘附素的机械转导、HIPPO/YAP途径、通过细胞黏附受体发出信号的系统生物学方法，以及其他黏附受体发出的信号。会议将汇集代表各种学科、方法和系统的发言者、讨论者和与会者。会议规模小，气氛非正式，将促进讨论和互动。随之而来的GRS将为学生和博士后研究员提供一个联网和共享数据的论坛，并将大大加强教育部分。我们对这些受体的调节功能的理解取得了重大进展，特别是对信号和机械转导的基本生物物理机制以及与发育和疾病的联系的新见解，使这次会议特别及时。 公共卫生相关性：本次会议的主要目标是加快研究整合素、钙粘附素和其他黏附受体信号的生物物理学、生物化学、细胞生物学、发育生物学和整个生物体生理学/病理学的研究人员的进展。将来自这些不同领域的研究人员聚集在一起，有可能通过相互促进和推广两种方式促进重大进展，在这种情况下，可以将一个领域的想法和方法应用于另一个领域，而在这种情况下，广泛的原则是显而易见的。更深入地了解细胞黏附受体信号传递的基本分子、细胞和组织基础，将有助于更好地理解出生缺陷、心血管疾病和癌症等人类健康中的其他主要问题。