2010 New Antimicrobial Drug Discovery and Development Gordon Research Conference

2010新型抗菌药物发现与开发戈登研究会议

• 批准号: 7906349
• 负责人: George Louis Drusano
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7906349
• 关键词: Academia; Accident and Emergency department; Acinetobacter; Antibiotics; Carbapenems; Colistin; Communities; Development; Enzymes; Escherichia coli; Eye; Hearing; Industry; Infection; Intensive Care Units; International; Klebsiella; Lactamase; Licensing; Macrolides; Measures; Monobactams; Organism; Postdoctoral Fellow; Predisposition; Prevalence; Process; Pseudomonas aeruginosa; Research; Resistance; Resistance profile; Science; Scientist; Site; Staphylococcus aureus; Streptococcus pneumoniae; Structure; Therapeutic Intervention; United States; Voice; antimicrobial; antimicrobial drug; drug discovery; meetings; member; methicillin resistant Staphylococcus aureus; pathogen; symposium

DESCRIPTION (provided by applicant): This Gordon Conference is aimed at a serious national and international problem: the lack of new antimicrobial agents for multi-resistant infections. In both the Intensive Care Unit (ICU) and the Community, organisms that commonly cause serious infections have become resistant to many of our most effective antibiotics. In the Community, organisms such as Streptococcus pneumonia have a rate of non- susceptibility to ¿-lactam antibiotics exceeding 20%. Other effective agents, such as macrolides, have resistance rates on the order of 40%. Community-Acquired MRSA has exploded in prevalence across the United States and is commonly seen in Emergency Departments. In the ICU, MRSA makes up approximately 50% of all Staphylococcus aureus infections and we have seen the advent of multi- resistant Gram-negative organisms, so that even common pathogens such as Klebsiella and E. coli may carry extended-spectrum ¿-lactamases, rendering them resistant to many of our best agents and, in the case of K-pc enzymes, this resistance profile includes carbapenems. In the case of Pseudomonas aeruginosa and Acinetobacter species, it is now reasonably common for an infecting pathogen to be resistant to all licensed antibiotics. A measure of our desperation is that we have resurrected 50 year-old, relatively toxic agents (colistin/polymixins) to have at least one available therapeutic intervention. In this Conference, we have a unique cross-disciplinary approach to the problem, where chemists, basic biologists and translational scientists meet and where Industry, Academia, Regulatory Agencies and political observers are all stakeholders and are invited to contribute to the interchange. Our past meetings have been scientifically rigorous and open, with both new science coming forward and the identification of bottlenecks in the process being part of the process. We have a conference where we are dedicated to the broadest participation and, in specific, are desirous of inclusion of younger members of the field at the post-doctoral level, to bring fresh perspective to the problems being examined. The site is well-suited for this interchange and the structure of the Conference follows the classical Gordon Conference format. The Discussion Leaders have been chosen with an eye toward generating robust, insightful discussion after the presentations. The format is democratic so that all voices will be heard and the emphasis will be on presenting the best and newest science and asking the correct questions to push the field forward. In this proposal, we ask for supplementary support for this important undertaking.

描述（由适用提供）：这次戈登会议针对的是一个严重的国家和国际问题：缺乏用于多耐药感染的新抗菌剂。在重症监护病房（ICU）和社区中，通常引起严重感染的生物已经对我们许多最有效的抗生素具有抵抗力。在社区中，诸如肺炎链球菌之类的生物具有非易感性 - lactam抗生素超过20％。其他有效的药物（例如大环内酯类）的耐药率在40％的阶段。社区获得的MRSA在美国各地探索了普遍存在，通常在急诊室中出现。 In the ICU, MRSA makes up approximately 50% of all Staphylococcus aureus infections and we have seen the advance of multi-resistant Gram-negative organisms, so that even common pathogens Such as Klebsiella and E. coli may carry extended-spectrum ¿ -lactamases, rendering them resistant to many of our best agents and, in the case of K-pc enzymes, this resistance profile includes碳青霉烯。对于铜绿假单胞菌和杆菌种类，现在感染的病原体对所有有执照的抗生素具有抗药性是合理的。对我们的任务的一种衡量标准是，我们已经返回了50岁的相对毒性的剂（Colistin/Polymixins）至少进行一种可用的治疗。干涉。 在这次会议上，我们对该问题采用了独特的跨学科方法，化学家，基本生物学家和翻译科学家会面，而行业，学术界，监管机构和政治观察家都是利益相关者，并受邀为交换做出贡献。我们过去的会议在科学上是严格和开放的，新科学都挺身而出，并且在此过程中可以识别瓶颈。 我们举行了一次会议，我们致力于最广泛的参与，并且特别是希望在博士后一级纳入该领域的年轻成员，以对所检查的问题提出新的观点。该网站非常适合这种交换，会议的结构遵循古典戈登会议形式。讨论领导者是为了在演讲之后引起强大而有见地的讨论。这种格式是民主的，因此将听到所有声音，重点将是介绍最好和最新的科学，并提出正确的问题以推动领域的前进。在此提案中，我们要求为这项重要任务提供补充支持。