Functional MRI Core Facility

功能性核磁共振核心设施

• 批准号: 7970138
• 负责人: Peter Bandettini
• 金额: $ 290.36万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7970138
• 关键词: Address; Adolescent; Agreement; Americas; Amygdaloid structure; Anatomy; Archives; Arts; Awareness; Basic Science; Bipolar Disorder; Boxing; Brain; Cerebral cortex; Child; Clinical; Code; Communication; Communities; Complement; Complex; Computers; Consult; Core Facility; Custom; Data; Development; Devices; Diamond; Documentation; Education; Electronics; Electrostatics; Employee; Ensure; Environment; Equipment; Eye; Eye Movements; Face; Feedback; Fiber Optics; Floor; Focus Groups; Frequencies; Functional Magnetic Resonance Imaging; Galvanic Skin Response; Genetic Risk; Genetic Variation; Goals; Hour; Human; Image; Impulsivity; Individual; Information Technology; Institutes; Joystick; Lamivudine; MRI Scans; Magnetic Resonance Imaging; Maintenance; Measures; Methods; Mission; Molecular; Monitor; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; National Institute on Deafness and Other Communication Disorders; Neurons; Neurosciences; Noise; Nuclear Magnetic Resonance; Operative Surgical Procedures; Participant; Patients; Peer Review; Physiologic pulse; Physiology; Policies; Price; Primates; Principal Investigator; Procedures; Process; Property; Protocols documentation; Psychiatry; Publications; Publishing; Radio; Research; Research Personnel; Research Subjects; Research Support; Resolution; Resources; Rewards; Running; Scanning; Schedule; Scientist; Services; Signal Transduction; Site; Specialist; Spectrum Analysis; Speed; Staging; System; Techniques; Technology; Time; Training; Translating; United States National Academy of Sciences; United States National Institutes of Health; Update; Variant; Violence; Visual; base; biobehavior; clinically relevant; digital; finesse; fly; insight; meetings; morphometry; neurofeedback; neuroimaging; neuromechanism; nonhuman primate; quality assurance; relating to nervous system; research study; respiratory; response; square foot; symposium; tool; web site

Space Utilization: The Functional MRI Facility (FMRIF) currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, and 1.5T MRI scanners located within the NMR center and office space on the second floor above the NMR center in the FMRIF/SFIM suite (approximately 1400 sq ft total, including shared conference space). Staff: The FMRIF staff (currently 15 full time employees) consist of: the facility director, four staff scientists to keep the scanners running, eight MRI technologists, an information technology (IT) specialist, and an administrative lab manager. Core users: The functional MRI facility supports the research of about 30 Principle Investigators which translates to about 300 researchers overall. Approximately 70 research protocols are active and making use of FMRIF scanners. Each scanner has scheduled operating hours of 105 hours per week. Since the year 2000 until Sep 2009 there were about 500 peer reviewed publications published with data acquired on FMRIF MRI scanners and with facility assistance (about 350 since 2006). High Impact Publications since about 2006 (based on citations): Meyer-Lindenberg A., Buckholtz J.W., Kolachana B., Hariri A.R., Pezawas L., Blasi G., Wabnitz A., Honea R., Verchinski B., Callicott J.H., Egan M., Mattay V., Weinberger D.R. Neural mechanisms of genetic risk for impulsivity and violence in humans (2006) Proceedings of the National Academy of Sciences of the United States of America, 103 (16), pp. 6269-6274. Cited 129 times. ---------------------------------------- Birn R.M., Diamond J.B., Smith M.A., Bandettini P.A. Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI (2006) NeuroImage, 31 (4), pp. 1536-1548. Cited 101 times. ---------------------------------------- Lenroot R.K., Giedd J.N. Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging (2006) Neuroscience and Biobehavioral Reviews, 30 (6), pp. 718-729. Cited 89 times. ---------------------------------------- Meyer-Lindenberg A., Nichols T., Callicott J.H., Ding J., Kolachana B., Buckholtz J., Mattay V.S., Egan M., Weinberger D.R. Impact of complex genetic variation in COMT on human brain function (2006) Molecular Psychiatry, 11 (9), pp. 867-877. Cited 61 times. ---------------------------------------- Pessoa L., Japee S., Sturman D., Ungerleider L.G. Target visibility and visual awareness modulate amygdala responses to fearful faces (2006) Cerebral Cortex, 16 (3), pp. 366-375. Cited 55 times. ---------------------------------------- Nugent A.C., Milham M.P., Bain E.E., Mah L., Cannon D.M., Marrett S., Zarate C.A., Pine D.S., Price J.L., Drevets W.C. Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry (2006) NeuroImage, 30 (2), pp. 485-497. Cited 44 times. ---------------------------------------- Dreher J.-C., Kohn P., Berman K.F. Neural coding of distinct statistical properties of reward information in humans (2006) Cerebral Cortex, 16 (4), pp. 561-573. Cited 42 times. Accomplishments: The FMRIF completed a major renovation and equipment upgrade in 2007/2008 and now operates three General Electric 3T MRI scanners as well as one General Electric 1.5T MRI scanner. With these new systems our 3T scanning capacity increased approximately 50% (two 3T scanners in 2007 to three 3T scanners in Jan 2008). The new scanners are short-bore General Electric 3 Tesla MRI systems: one is equipped with 16 MRI signal receivers (or channels) and is also equipped for spectroscopy experiments, while the other has 32 channels which can be used for high-resolution functional brain mappping experiments. Both scanners are equipped with an array of RF coils or receivers which provide a state of the art scanning environment. The scanners are equipped with a full system for interfacing with research subjects, including video delivered using high-speed digital projectors and electrostatic audio systems that are MR compatible. These devices are complemented with MR compatible methods for measuring subject/patient physiology in the magnets as well as fiber-optic systems for providing subject feedback and infrared video systems for monitoring eye movements in the magnet. All FMRIF MRI scanners are available for research 14 hours a day and 7 days a week. To ensure high quality imaging data and to reduce scanner down time, advance daily quality assurance procedures have been developed. An additional development includes real-time fMRI capability. This also allows for conducting fMRI experiments involving neurofeedback to the subject. All imaging data are extracted from the MRI scanner, converted, and saved on the fly onto dedicated computers together with complete electronic documentation of all performed scans. In the past year, the functional MRI facility has established a primate imaging platform for anatomical and functional MRI studies of nonhuman primates. This involved the integration of a custom mounting device and coil in addition to a protocol that seamlessly allows the transition of use of the scanner for imaging primates at 1.5T and 3T. This has become a useful tool for those researchers in the NIH that would like to complement their human fMRI studies with primate studies. A major accomplishment of the core facility last year was in association with the renovations revolving around installation of the new 3T scanner. These renovations required one of our 3T scanners be shut down. Handling this renovation required adjusting the user schedule and establishing temporary time on a scanner owned by GE but set up at the NIH in accordance with a research agreement. This required finesse on the part of the facility staff to manage this transfer. Most users were quite happy with how this was handled, as their research was not significantly interrupted. Lastly, the core facility is in the final stages of purchasing a 7T scanner (replacing one of the 3T scanners) and possibly up to two 3T scanners (one potentially replacing the 1.5T scanner and one additional scanner). These scanners all should be up and running within nine months.

空间利用率： 功能性 MRI 设施 (FMRIF) 目前占据约 4800 平方英尺的空间，分为位于 NMR 中心内的 3TA、3TB、3TC 和 1.5T MRI 扫描仪的扫描仪隔间、控制室和电子/机器房以及 FMRIF/SFIM 套件中 NMR 中心上方二楼的办公空间（总面积约 1400 平方英尺，包括共享会议空间） 空间）。 职员： FMRIF 工作人员（目前有 15 名全职员工）包括：设施主管、四名负责保持扫描仪运行的科学家、八名 MRI 技术人员、一名信息技术 (IT) 专家和一名实验室行政经理。 核心用户： 功能性 MRI 设施支持约 30 名主要研究人员的研究，相当于总共约 300 名研究人员。大约 70 个研究方案正在使用 FMRIF 扫描仪。每台扫描仪的预定运行时间为每周 105 小时。 自 2000 年至 2009 年 9 月，约有 500 篇同行评审出版物发表了使用 FMRIF MRI 扫描仪和设施协助获取的数据（自 2006 年以来约 350 篇）。 自 2006 年左右以来的高影响力出版物（基于引用）： Meyer-Lindenberg A.、Buckholtz J.W.、Kolachana B.、Hariri A.R.、Pezawas L.、Blasi G.、Wabnitz A.、Honea R.、Verchinski B.、Callicott J.H.、Egan M.、Matty V.、Weinberger D.R. 人类冲动和暴力遗传风险的神经机制 (2006) 美国国家科学院院刊，103 (16)，第 6269-6274 页。被引用129次。 ---------------------------------------------------- Birn R.M.、Diamond J.B.、Smith M.A.、Bandettini P.A. 在功能磁共振成像中将呼吸变化相关的波动与神经元活动相关的波动分开 (2006) NeuroImage，31 (4)，第 1536-1548 页。被引用101次。 ---------------------------------------------------- Lenroot R.K.，Giedd J.N. 儿童和青少年的大脑发育：解剖磁共振成像的见解 (2006) 神经科学和生物行为评论，30 (6)，第 718-729 页。被引用89次。 ---------------------------------------------------- Meyer-Lindenberg A.、Nichols T.、Callicott J.H.、Ding J.、Kolachana B.、Buckholtz J.、Mattay V.S.、Egan M.、Weinberger D.R. COMT 复杂遗传变异对人脑功能的影响 (2006) 分子精神病学，11 (9)，第 867-877 页。被引用 61 次。 ---------------------------------------------------- Pessoa L.、Japee S.、Sturman D.、Ungerleider L.G. 目标可见度和视觉意识调节杏仁核对恐惧面孔的反应 (2006) 大脑皮层，16 (3)，第 366-375 页。被引用55次。 ---------------------------------------------------- Nugent A.C.、Milham M.P.、Bain E.E.、Mah L.、Cannon D.M.、Marrett S.、Zarate C.A.、Pine D.S.、Price J.L.、Drevets W.C. 通过 MRI 和基于体素的形态测量研究双相情感障碍的皮质异常 (2006) NeuroImage，30 (2)，第 485-497 页。被引用44次。 ---------------------------------------------------- Dreher J.-C.、Kohn P.、Berman K.F. 人类奖励信息的独特统计特性的神经编码 (2006) 大脑皮层，16 (4)，第 561-573 页。被引用42次。 Accomplishments: FMRIF 在 2007/2008 年完成了重大改造和设备升级，现在运行三台通用电气 3T MRI 扫描仪和一台通用电气 1.5T MRI 扫描仪。借助这些新系统，我们的 3T 扫描能力增加了约 50%（2007 年的两台 3T 扫描仪到 2008 年 1 月增加了三台 3T 扫描仪）。 新扫描仪是短口径通用电气3 Tesla MRI系统：一套配备16个MRI信号接收器（或通道），也可用于光谱学实验，而另一套配备32个通道，可用于高分辨率功能性脑图谱实验。两台扫描仪都配备了射频线圈或接收器阵列，可提供最先进的扫描环境。 扫描仪配备了与研究对象连接的完整系统，包括使用高速数字投影仪传输的视频和与 MR 兼容的静电音频系统。这些设备还配有用于测量磁体中受试者/患者生理机能的 MR 兼容方法，以及用于提供受试者反馈的光纤系统和用于监测磁体中眼球运动的红外视频系统。所有 FMRIF MRI 扫描仪每周 7 天、每天 14 小时可供研究。为了确保高质量的成像数据并减少扫描仪停机时间，我们制定了先进的日常质量保证程序。 另一项开发包括实时功能磁共振成像功能。这也允许进行涉及受试者神经反馈的功能磁共振成像实验。所有成像数据均从 MRI 扫描仪中提取、转换并即时保存到专用计算机上，以及所有执行扫描的完整电子文档。 去年，功能性核磁共振设施建立了灵长类动物成像平台，用于非人类灵长类动物的解剖和功能性核磁共振研究。这涉及定制安装设备和线圈的集成，以及允许无缝过渡扫描仪在 1.5T 和 3T 下对灵长类动物成像的协议。对于 NIH 的研究人员来说，这已成为一个有用的工具，他们希望用灵长类动物研究来补充他们的人类功能磁共振成像研究。 去年核心设施的一项重大成就是围绕安装新 3T 扫描仪进行的翻修。这些改造需要关闭我们的一台 3T 扫描仪。处理这项改造需要调整用户日程安排，并在 GE 拥有但根据研究协议在 NIH 设置的扫描仪上建立临时时间。这需要设施工作人员巧妙地管理这次转移。大多数用户对处理方式非常满意，因为他们的研究没有受到明显干扰。 最后，核心设施正处于购买一台 7T 扫描仪（替换其中一台 3T 扫描仪）和可能最多两台 3T 扫描仪（一台可能替换 1.5T 扫描仪和一台额外扫描仪）的最后阶段。这些扫描仪应在九个月内全部启动并运行。