Functional MRI Core Facility

功能性核磁共振核心设施

• 批准号: 9589767
• 负责人: Peter Bandettini
• 金额: $ 405.33万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9589767
• 关键词: Acceleration; Blood; Brain; Central Vein; Chills; Collaborations; Communication; Communities; Computer software; Contracts; Core Facility; Data; Development; Education; Electroencephalography; Electronics; Eye; Feedback; Floor; Functional Magnetic Resonance Imaging; Goals; Head; Hippocampus (Brain); Hour; Human; Image; Individual; Information Technology; Institutes; Kinetics; Laboratories; Lamivudine; Magnetic Resonance Imaging; Maintenance; Maps; Measurement; Measures; Methods; Mission; Modality; Motion; National Human Genome Research Institute; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; Noise; Nuclear Magnetic Resonance; Paper; Participant; Peer Review; Performance; Perfusion; Phase; Physiologic pulse; Policies; Population; Positioning Attribute; Predisposition; Principal Investigator; Procedures; Process; Protocols documentation; Publications; Quality Control; Recovery; Research; Research Personnel; Research Support; Resolution; Resources; Running; Scanning; Schedule; Scientist; Signal Transduction; Site; Slice; Specialist; Speed; Standardization; Structure of terminal stria nuclei of preoptic region; System; Techniques; Testing; Time; Translating; Travel; Vendor; Water; Work; anatomic imaging; base; correctional system; data sharing; density; design and construction; experimental study; high resolution imaging; image reconstruction; imaging detection; improved; indexing; meetings; neurofeedback; new technology; prisma; reconstruction; repository; square foot; symposium; visual stimulus

Protocol number 93-M-0170, NCT00001360 Space Utilization: The Functional MRI Facility (FMRIF) currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, 3TD, and 7T MRI scanners located within the NMR center and office space on the second floor above the NMR center in the FMRIF/SFIM suite (approximately 1400 sq ft total, including shared conference space). The FMRIF staff (currently 14 full- time positions) consists of: the facility director, four staff scientists to keep the scanners running, six MRI technologists, an information technology specialist, a programmer, and an administrative laboratory manger. The functional MRI facility supports the research of over 30 Principal Investigators translating to over 300 researchers overall. Over 70 research protocols are active and making use of FMRIF scanners. Each scanner has scheduled operating hours of 105 hours per week. Since its inception in 2000 until August 2017, a total of 1,126 peer-reviewed publications from intramural investigators have used data acquired in the FMRIF core facility. The total is distributed among 747 papers from NIMH, 280 papers from NINDS, and 99 from the other institutes. These papers have been cited a total of 106,561 times for a combined h-index of 161. In other words, 161 papers using the FMRIF have been cited at least 161 times." Projects: Projects: Staff Scientists working on projects are designated as: Sean Marrett (SM), Vinai Roopchansingh (VR), Andy Derbyshire (AD), and Linquing Li (LL). The goals of these projects are aimed to increase the overall utility of the fMRI core facility for the most possible users. Upgrade 3TA/B: SM and VR managed contracting, planning, design, construction and final equipping of upgraded 3TA/3TB suite and systems from HDx to mr750 platform including access to better chilled water. They also upgraded the visual stimulus system for 3TB. High resolution image recon: SM Continued collaboration with Laurentius Huber on high-resolution VASO/BOLD and TSNR optimized image reconstruction. New 7T host: SM acquired new 7T host to allow for more aggressive high-resolution scanning of humans on 7T with faster CPU and expanded storage. High resolution Simultaneous Multi-slice: SM established and validated routine high-resolution SMS imaging sequences on the 7T scanner (LBC/Baker,Grillon, Merriam) including routine whole brain 1.2mm3 and smaller field of view 0.9mm3 for imaging hippocampus and bed nucleus of stria terminalis Multi-modal integration: SM worked with Jen Evans and Peter Molfese on clarifying high density EEG acquisition procedures using EGI system. Automated Quality control: SM is currently implementing an automated MRI quality control system and automated BIDS data conversion software package (being tested by Jan Verada)in collaboration with data sharing team. Eye Tracking: SN us Acquiring/validating new high quality eye tracking systems for 3TA, 7T, and 3TD. Distortion correction testing: VR is working with Sue Swedo on testing distortion correction techniques on EPI and structural images. Real time EPI software: VR is developing real-time display and feedback software that runs on the FMRIF scanners. Most recently, these have been used for neuro-feedback experiments in a study of an autistic population by Alex Martins group in NIMH. There are upcoming potential collaboration using this capability, both from NHGRI (Philip Shaw) and NIAAA (Reza Momenan). Gadgetron: VR has continued his involvement with the ISMRMRD and Gadgetron projects. Over the last year, he has openly made available (in a public GitHub repository) a template ISMRMRD converter that converts data from General Electric scanners into the ISMRMRD format. He will continue his involvement to leverage the advantage the Gadgetron and ISMRMRD hold for the plethora of platforms the FMRIF currently supports. Blood nulling implementation: LL is working on implementing a method by which intravascular spins travelling at velocities above 2-3 mm/sec are nulled. The sequence that performs this nulling is called a DANTE-EPI sequence. The goal is to increase localization of fMRI by eliminating downstream vessels. Dynamic Phase Correction: AD has implemented dynamic phase correction for multi-echo EPI. EPI-based T1 mapping: AD has developed a variable flip-angle multi-echo EPI sequence to simultaneously measure the BOLD signal and the T1 map using multi-echo EPI-based fMRI sequence. A modified multi-echo EPI sequence is used for quantitative measurement of fMRI signal. LL has established a standard, non-EPI, approach to T1 mapping using Inversion recovery prepared Turbo spin echo (TSE). Head Gradient Coil: AD and VR have been examining the performance and impact of a local head gradient coil for the FMRIF scanner systems. Cross scanner comparison work: AD is developing common pulse sequence components to develop "standardized" (to the limits of the MR hardware) pulse sequences across various MRI platforms. This is analogous to the complementary efforts to employ vendor independent reconstructions. 3D-EPI support: AD is Supporting development of a 3D-EPI sequence by Daniel Reichs group for high resolution susceptibility weighted imaging for the detection of MS plaques with a central vein. This work involves maintaining pulse sequences for sites in their multi-center initiative, as well as improving the existing sequence -- e.g., adding multi-dimensional acceleration and motion correction. Motion correction: AD is Assisting with their efforts to use the Kineticor motion correction system in combination with Dr. Talagalas pCASL-EPI perfusion sequence.

方案编号93-M-0170，NCT 00001360 空间利用率： 功能性磁共振成像设施（FMRIF）目前占地约4800平方米。300平方英尺的空间，分为扫描仪间、控制室和3 TA、3 TB、3 TC、3 TD和7 T MRI扫描仪的电子/机器室，位于NMR中心内，办公空间位于NMR中心上方的二楼，位于FMRIF/Scrum套房内（总面积约为1400平方英尺，包括共享会议空间）。 FMRIF的工作人员（目前有14个全职职位）包括：设施主任、4名保持扫描仪运行的科学家、6名MRI技术人员、1名信息技术专家、1名程序员和1名行政实验室经理。 功能性磁共振成像设施支持30多名主要研究人员的研究，总共有300多名研究人员。超过70个研究方案正在使用FMRIF扫描仪。每台扫描仪的预定工作时间为每周105小时。 自2000年成立至2017年8月，共有1，126篇来自内部研究人员的同行评审出版物使用了FMRIF核心设施中获得的数据。其中NIMH的747篇，NINDS的280篇，其他研究所的99篇。这些论文共被引用106，561次，综合h指数为161。换句话说，使用FMRIF的161篇论文至少被引用了161次。" 项目： 项目：参与项目的科学家被指定为：Sean Marrett（SM），Vinai Roopchansingh（VR），Andy Derbyshire（AD）和Linquing Li（LL）。这些项目的目标是提高功能磁共振成像核心设施的整体效用，为最可能的用户。 升级3 TA/B：SM和VR管理从HDx到mr 750平台的升级3 TA/3 TB套件和系统的承包、规划、设计、施工和最终装备，包括获得更好的冷冻水。他们还将视觉刺激系统升级为3 TB。 高分辨率图像重建：SM继续与Laurentius Huber合作，进行高分辨率VASO/BOLD和TSNR优化图像重建。 新的7 T主机：SM收购了新的7 T主机，以允许在7 T上使用更快的CPU和扩展的存储进行更积极的高分辨率人体扫描。 高分辨率同步多层切片：SM在7 T扫描仪（LBC/Baker、格里永、梅里亚姆）上建立并验证了常规高分辨率SMS成像序列，包括常规全脑1.2 mm 3和较小视野0.9 mm 3，用于海马和终纹床核成像 多模态集成：SM与Jen Evans和Peter Molfese合作，使用EGI系统阐明高密度EEG采集程序。 自动化质量控制：SM目前正在与数据共享团队合作实施自动化MRI质量控制系统和自动化BIDS数据转换软件包（由Jan Verada测试）。 眼动追踪：SN us为3 TA、7 T和3 TD采购/验证新的高质量眼动追踪系统。 失真校正测试：VR正在与Sue Swedo合作，在EPI和结构图像上测试失真校正技术。 真实的实时EPI软件：VR正在开发在FMRIF扫描仪上运行的实时显示和反馈软件。最近，NIMH的亚历克斯·马丁斯小组在一项对自闭症人群的研究中，将这些用于神经反馈实验。NHGRI（Philip Shaw）和NIAAA（Reza Momenan）即将使用此功能进行潜在的合作。 Gadgetron：VR继续参与ISMRMRD和Gadgetron项目。在过去的一年里，他公开提供了（在公共GitHub存储库中）一个模板ISMRMRD转换器，可以将通用电气扫描仪的数据转换为ISMRMRD格式。他将继续参与，以利用Gadgetron和ISMRMRD为FMRIF目前支持的众多平台所拥有的优势。 血液归零实施：LL正在致力于实现一种方法，通过该方法，以2-3 mm/sec以上的速度行进的血管内自旋被归零。执行该置零的序列被称为DANTE-EPI序列。其目的是通过消除下游血管来增加fMRI的定位。 动态相位校正：AD已经为多回波EPI实现了动态相位校正。 基于EPI的T1标测：AD开发了一种可变翻转角多回波EPI序列，使用基于多回波EPI的fMRI序列同时测量BOLD信号和T1图。采用改进的多回波EPI序列对fMRI信号进行定量测量。 LL已经建立了一种标准的非EPI方法，使用反转恢复准备的Turbo自旋回波（TSE）进行T1标测。 头部梯度线圈：AD和VR一直在检查FMRIF扫描仪系统的局部头部梯度线圈的性能和影响。 交叉扫描仪比较工作：AD正在开发通用脉冲序列组件，以开发跨各种MRI平台的“标准化”（达到MR硬件的限制）脉冲序列。这类似于采用供应商独立重建的补充努力。 3D-EPI支持：AD支持丹尼尔Reichs小组开发3D-EPI序列，用于高分辨率磁敏感加权成像，以检测具有中心静脉的MS斑块。这项工作涉及在其多中心倡议中维护站点的脉冲序列，以及改进现有序列-例如，添加多维加速和运动校正。 运动校正：AD正在协助他们努力将Kineticor运动校正系统与Talagalas博士的pCASL-EPI灌注序列结合使用。