Clinical Support Services for the NIAMS Intramural Research Program

该项目为以下临床方案提供了研究基础设施支持： 91-AR-0196多发性肌炎、皮肌炎及相关疾病的自然病史和发病机制研究 94-AR-0066系统性红斑狼疮发病机制及自然病史的研究 家族性地中海热及相关疾病的遗传学和病理生理学研究 99-D-0070唾液腺功能障碍和干燥综合征的自然病史 00-AR-0222关于关节炎发病机制和自然病史及相关条件的研究 01-AR-0227少数民族风湿病自然病史 02-AR-0156英夫利昔单抗治疗皮肌炎和多发性肌炎的随机、双盲、安慰剂对照试验 03-AR-0130基因决定强直性脊柱炎严重程度的横断面研究 03-AR-0131强直性脊柱炎严重程度的遗传决定因素-纵向研究 03-AR-0133类风湿性关节炎的临床重要变化 03-AR-0173新生儿首发多系统炎症性疾病(NOMID)自然病史及发病机制的研究 03-AR-0298 IL-1受体拮抗剂Anakinra/Kineet在新生儿首发多系统炎症性疾病(NOMID/CINCA综合征)患者中的初步研究 04-AR-0205强直性脊柱炎脊柱融合进展 05-AR-0014成人自身炎症性疾病患者IL-1陷阱的先导性开放标记研究：一种研究发病机制的治疗方法 07-E-0012利妥昔单抗治疗成人和青少年难治性皮肌炎和多发性肌炎 08-AR-0008胰岛素抵抗与系统性红斑狼疮患者动脉粥样硬化 08-AR-0218利诺奈普治疗家族性地中海热 09-AR-0066 Canakinumab治疗新生儿首发多系统炎症性疾病

This project has provided research infrastructure support for the following clinical protocols: 91-AR-0196 Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases 94-AR-0066 Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE) 94-AR-0105 Genetics and Pathophysiology of Familial Mediterranean Fever and Related Disorders 99-D-0070 Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome 00-AR-0222 Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions 01-AR-0227 Natural History of Rheumatic Disease in Minority Communities 02-AR-0156 A Randomized, Double-Blind, Placebo-Controlled Trial of Infliximab in Patients with Dermatomyositis and Polymyositis 03-AR-0130 Genetic Determinants of Ankylosing Spondylitis Severity - Cross Sectional Study 03-AR-0131 Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study 03-AR-0133 Clinically Important Changes in Rheumatoid Arthritis 03-AR-0173 Studies of the Natural History and Pathogenesis of Neonatal Onset Multisystem Inflammatory Disease (NOMID) 03-AR-0298 A Pilot Study of the IL-1 Receptor Antagonist Anakinra/Kineret in Patients with Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) 04-AR-0205 Progression of Spinal Fusion in Ankylosing Spondylitis 05-AR-0014 A Pilot Open-Label Study of IL-1 Trap in Adult Subjects with Autoinflammatory Disease: A Therapeutic Approach to Study Pathogenesis 07-E-0012 Rituximab in the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Polymyositis (PM) 08-AR-0008 Insulin Resistance and Atherosclerosis in a Sample of Women with Systemic Lupus Erythematosus 08-AR-0218 Rilonacept to Treat Familial Mediterranean Fever 09-AR-0066 Canakinumab to Treat Neonatal Onset Multisystem Inflammatory Disease