Clinical Support Services for the NIAMS Intramural Research Program

NIAMS 校内研究项目的临床支持服务

• 批准号: 7732845
• 负责人: Daniel Kastner
• 金额: $ 338.95万
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732845
• 关键词: Adult; Alli; Ambulatory Care Facilities; Anesthetics; Ankylosing spondylitis; Appointments and Schedules; Arthritis; Atherosclerosis; Autoimmunity; Case-Control Studies; Child; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Communities; Community Health Centers; Computer software; Condition; Contracts; Cross-Sectional Studies; Cyclophosphamide; Databases; Dermatomyositis; Disease; District of Columbia; Dose; Etanercept; Familial Mediterranean Fever; Family; Functional disorder; Genetic; Genetic Determinism; Genets; Hospitalists; Hydrocortisone; Inflammatory; Insulin Resistance; Interleukin-1; Interleukin-1 Receptors; Intramural Research Program; Kineret; Label; Life; Long-Term Effects; Longitudinal Studies; Lupus Nephritis; Manuscripts; Measurement; Medical; Minority; Natural History; Neonatal; Numbers; Nurse Practitioners; Nursing Research; Occupational; Outcome; Paper; Pathogenesis; Patients; Perimenopause; Physical Function; Physical activity; Physicians; Physiologic pulse; Pilot Projects; Polymyositis; Population; Premenopause; Preparation; Publications; Publishing; Pulse taking; Randomized; Refractory; Relapse; Research; Research Ethics Committees; Research Infrastructure; Research Support; Rheum; Rheumatism; Rheumatoid Arthritis; Rheumatology; Salivary Glands; Sampling; Sarcoidosis; Scanning; Services; Severities; Sjogren' s Syndrome; Somatotropin; Spinal Fusion; Syndrome; System; Systemic Lupus Erythematosus; Therapeutic; Training Programs; Translational Research; Travel; United States National Institutes of Health; Variant; Woman; Work; Wrist; X-Ray Computed Tomography; anakinra; austin; base; bench to bedside; carpus bone; cost; dehydroepiandrosterone; double-blind placebo controlled trial; fludarabine; infliximab; neuropsychiatry; programs; rituximab; ward

This project has provided research infrastructure support for the following clinical protocols: 91-AR-0196 Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases 94-AR-0066 Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE) 94-AR-0105 Genetics and Pathophysiology of Familial Mediterranean Fever and Related Disorders 99-D-0070 Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome 00-AR-0222 Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions 01-AR-0227 Natural History of Rheumatic Disease in Minority Communities 02-AR-0156 A Randomized, Double-Blind, Placebo-Controlled Trial of Infliximab in Patients with Dermatomyositis and Polymyositis 03-AR-0130 Genetic Determinants of Ankylosing Spondylitis Severity - Cross Sectional Study 03-AR-0131 Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study 03-AR-0133 Clinically Important Changes in Rheumatoid Arthritis 03-AR-0173 Studies of the Natural History and Pathogenesis of Neonatal Onset Multisystem Inflammatory Disease (NOMID) 03-AR-0298 A Pilot Study of the IL-1 Receptor Antagonist Anakinra/Kineret in Patients with Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) 04-AR-0205 Progression of Spinal Fusion in Ankylosing Spondylitis 05-AR-0014 A Pilot Open-Label Study of IL-1 Trap in Adult Subjects with Autoinflammatory Disease: A Therapeutic Approach to Study Pathogenesis 07-E-0012 Rituximab in the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Polymyositis (PM) 08-AR-0008 Insulin Resistance and Atherosclerosis in a Sample of Women with Systemic Lupus Erythematosus In addition to the manuscripts listed in the Publications section, there are a number of other published papers that are based upon clinical support services provided through this project. They include: 1. Hill SC, Namde M, Dwyer A, Poznanski A, Canna S, Goldbach-Mansky R (2007) Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA). Pediatr Radiol 37:145-52. 2. Duryea J, Magalnick M, Alli S, Yao L, Wilson M, Goldbach-Mansky R (2008) Semiautomated three-dimensional segmentation software to quantify carpal bone volume changes on wrist CT scans for arthritis assessment. Med Phys 35:2321-30. 3. Glaser RL, Goldbach-Mansky R (2008) The spectrum of autoinflammatory diseases: recent bench to bedside observations. Curr Opin Rheumatol 20:66-75. 4. Blackman MR, Muniyappa R, Wilson M, Moquin BE, Baldwin HL, Wong KA, Snyder C, Magalnick M, Alli S, Reynolds J, Steinber SM, Goldbach-Mansky R (2007) Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study. Arthritis Res Ther 9:R73. 5. Lauro CF, Goldbach-Mansky R, Schmidt M, Quezado ZM (2007) The anesthetic management of children with neonatal-onset multi-system inflammatory disease. Anesth Analg 105:351-7. 6. Louie GH, Chitkara P, Ward MM (2008) Relapse of sarcoidosis upon treatment with etanercept. Ann Rheum Dise 67:896-8. 7. Ward MM (2007) Association scan of 14,500 nsSNPs in four common diseases identifies variants involved in autoimmunity (2007) Nat Genet 39:1329-37. 8. Ward MM (2007) Interpreting measurements of physical function in clinical trials. Ann Rheum Dis 66 Suppl 3:iii32-4. 9. Ward MM, Raveille JD, Learch TJ, Davis JC, Weisman MH (2008) Occupational physical activities and long-term functional and radiographic outcomes in patients with ankylosing spondylitis. Arthritis Rheum 59:822-32. 10. Ward MM, Reveille JD, Learch TJ, Davis JC, Weisman MH (2008) Impact of ankylosing spondylitis on work and family life: comparisons with the US population. Arthritis Rheum 59:497-503. 11. Illei GG (2007) The clinical impact of neuropsychiatric manifestations in early systemic lupus erythematosus. Nat Clin Pract Rheumatol 3:428-9. 12. Illei GG, Yarboro CH, Kuroiwa T, Schlimgen R, Austin HA, Tisdale JF, Chitkara P, Fleisher T, Klippel JH, Balow JE, Boumpas DT (2007) Long-term effects of combination treatment with fludarabine and low-dose pulse cyclophosphamide in patients with lupus nephritis. Rheumatology (Oxford) 46:952-6.

该项目为以下临床方案提供了研究基础设施支持： 91-AR-0196多发性肌炎、皮肌炎及相关疾病的自然病史和发病机制研究 94-AR-0066系统性红斑狼疮发病机制及自然病史的研究 家族性地中海热及相关疾病的遗传学和病理生理学研究 99-D-0070唾液腺功能障碍和干燥综合征的自然病史 00-AR-0222关于关节炎发病机制和自然病史及相关条件的研究 01-AR-0227少数民族风湿病自然病史 02-AR-0156英夫利昔单抗治疗皮肌炎和多发性肌炎的随机、双盲、安慰剂对照试验 03-AR-0130基因决定强直性脊柱炎严重程度的横断面研究 03-AR-0131强直性脊柱炎严重程度的遗传决定因素-纵向研究 03-AR-0133类风湿性关节炎的临床重要变化 03-AR-0173新生儿首发多系统炎症性疾病(NOMID)自然病史及发病机制的研究 03-AR-0298 IL-1受体拮抗剂Anakinra/Kineet在新生儿首发多系统炎症性疾病(NOMID/CINCA综合征)患者中的初步研究 04-AR-0205强直性脊柱炎脊柱融合进展 05-AR-0014成人自身炎症性疾病患者IL-1陷阱的先导性开放标记研究：一种研究发病机制的治疗方法 07-E-0012利妥昔单抗治疗成人和青少年难治性皮肌炎和多发性肌炎 08-AR-0008胰岛素抵抗与系统性红斑狼疮患者动脉粥样硬化 除了出版物部分列出的手稿外，还有一些其他已发表的论文是基于通过该项目提供的临床支持服务。它们包括： 1.Hill SC，Namde M，Dwyer A，Poznanski A，Canna S，Goldbach-Mansky R(2007)新生儿关节病起病多系统炎症性疾病。儿科医生37：145-52。 2.Duryea J，Magalnick M，Alli S，姚L，威尔逊M，Goldbach-Mansky R(2008)半自动三维分割软件，用于量化腕关节CT扫描上的腕骨体积变化，用于关节炎评估。医学史35：2321-30。 3.Gaser RL，Goldbach-Mansky R(2008)自体炎症性疾病的谱系：最新的从长凳到床边的观察。Curr Opin Rheumatol 20：66-75 4.Blackman MR，Muniyappa R，Wilson M，Moquin Be，Baldwin HL，Wong Ka，Snyder C，Magalnick M，Alli S，Reynolds J，Steinber SM，Goldbach-Mansky R(2007年)患有活动期类风湿关节炎的绝经前和围绝经期妇女的生长激素、皮质醇和脱氢表雄酮的每日分泌：一项试点病例对照研究。关节炎9：R73。 5.Lauro CF，Goldbach-Mansky R，Schmidt M，Quezado ZM(2007)新生儿多系统炎症性疾病儿童的麻醉管理。A A 105：351-7. 6.Louie GH，Chitkara P，Ward MM(2008)使用依那西普治疗后的结节病复发。安·兰姆·迪斯67：896-8。 7.Ward MM(2007)联合扫描了四种常见疾病中的14,500个nsSNP，发现了与自身免疫有关的变异(2007)NAT Genet 39：1329-37。 8.Ward MM(2007)在临床试验中解释身体机能的测量。安·兰姆Dis 66 Suppl 3：III32-4. 9.Ward MM，Raveille JD，Learch TJ，Davis JC，Weisman MH(2008)强直性脊柱炎患者的职业体力活动和长期功能和放射学结果。关节炎大黄59：822-32。 10.Ward MM，Reveille JD，Learch TJ，Davis JC，Weisman MH(2008)强直性脊柱炎对工作和家庭生活的影响：与美国人口的比较。关节炎大黄59：497-503。 11.Illei GG(2007)早期系统性红斑狼疮神经精神病学表现的临床影响。NAT Clin Pract Rheumatol 3：428-9. 12.Illei GG，Yarboro CH，Kuroiwa T，Schlimgen R，Austin HA，Tisdale JF，Chitkara P，Fleisher T，Klippel JH，Balow Je，Boumpas DT(2007)狼疮性肾炎患者氟达拉滨和小剂量脉冲环磷酰胺联合治疗的长期疗效。风湿病(牛津)46：952-6。