Clinical Support Services for the NIAMS Intramural Research Program

NIAMS 校内研究项目的临床支持服务

• 批准号: 7732845
• 负责人: Daniel Kastner
• 金额: $ 338.95万
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732845
• 关键词: Adult; Alli; Ambulatory Care Facilities; Anesthetics; Ankylosing spondylitis; Appointments and Schedules; Arthritis; Atherosclerosis; Autoimmunity; Case-Control Studies; Child; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Communities; Community Health Centers; Computer software; Condition; Contracts; Cross-Sectional Studies; Cyclophosphamide; Databases; Dermatomyositis; Disease; District of Columbia; Dose; Etanercept; Familial Mediterranean Fever; Family; Functional disorder; Genetic; Genetic Determinism; Genets; Hospitalists; Hydrocortisone; Inflammatory; Insulin Resistance; Interleukin-1; Interleukin-1 Receptors; Intramural Research Program; Kineret; Label; Life; Long-Term Effects; Longitudinal Studies; Lupus Nephritis; Manuscripts; Measurement; Medical; Minority; Natural History; Neonatal; Numbers; Nurse Practitioners; Nursing Research; Occupational; Outcome; Paper; Pathogenesis; Patients; Perimenopause; Physical Function; Physical activity; Physicians; Physiologic pulse; Pilot Projects; Polymyositis; Population; Premenopause; Preparation; Publications; Publishing; Pulse taking; Randomized; Refractory; Relapse; Research; Research Ethics Committees; Research Infrastructure; Research Support; Rheum; Rheumatism; Rheumatoid Arthritis; Rheumatology; Salivary Glands; Sampling; Sarcoidosis; Scanning; Services; Severities; Sjogren' s Syndrome; Somatotropin; Spinal Fusion; Syndrome; System; Systemic Lupus Erythematosus; Therapeutic; Training Programs; Translational Research; Travel; United States National Institutes of Health; Variant; Woman; Work; Wrist; X-Ray Computed Tomography; anakinra; austin; base; bench to bedside; carpus bone; cost; dehydroepiandrosterone; double-blind placebo controlled trial; fludarabine; infliximab; neuropsychiatry; programs; rituximab; ward

This project has provided research infrastructure support for the following clinical protocols: 91-AR-0196 Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases 94-AR-0066 Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE) 94-AR-0105 Genetics and Pathophysiology of Familial Mediterranean Fever and Related Disorders 99-D-0070 Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome 00-AR-0222 Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions 01-AR-0227 Natural History of Rheumatic Disease in Minority Communities 02-AR-0156 A Randomized, Double-Blind, Placebo-Controlled Trial of Infliximab in Patients with Dermatomyositis and Polymyositis 03-AR-0130 Genetic Determinants of Ankylosing Spondylitis Severity - Cross Sectional Study 03-AR-0131 Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study 03-AR-0133 Clinically Important Changes in Rheumatoid Arthritis 03-AR-0173 Studies of the Natural History and Pathogenesis of Neonatal Onset Multisystem Inflammatory Disease (NOMID) 03-AR-0298 A Pilot Study of the IL-1 Receptor Antagonist Anakinra/Kineret in Patients with Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) 04-AR-0205 Progression of Spinal Fusion in Ankylosing Spondylitis 05-AR-0014 A Pilot Open-Label Study of IL-1 Trap in Adult Subjects with Autoinflammatory Disease: A Therapeutic Approach to Study Pathogenesis 07-E-0012 Rituximab in the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Polymyositis (PM) 08-AR-0008 Insulin Resistance and Atherosclerosis in a Sample of Women with Systemic Lupus Erythematosus In addition to the manuscripts listed in the Publications section, there are a number of other published papers that are based upon clinical support services provided through this project. They include: 1. Hill SC, Namde M, Dwyer A, Poznanski A, Canna S, Goldbach-Mansky R (2007) Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA). Pediatr Radiol 37:145-52. 2. Duryea J, Magalnick M, Alli S, Yao L, Wilson M, Goldbach-Mansky R (2008) Semiautomated three-dimensional segmentation software to quantify carpal bone volume changes on wrist CT scans for arthritis assessment. Med Phys 35:2321-30. 3. Glaser RL, Goldbach-Mansky R (2008) The spectrum of autoinflammatory diseases: recent bench to bedside observations. Curr Opin Rheumatol 20:66-75. 4. Blackman MR, Muniyappa R, Wilson M, Moquin BE, Baldwin HL, Wong KA, Snyder C, Magalnick M, Alli S, Reynolds J, Steinber SM, Goldbach-Mansky R (2007) Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study. Arthritis Res Ther 9:R73. 5. Lauro CF, Goldbach-Mansky R, Schmidt M, Quezado ZM (2007) The anesthetic management of children with neonatal-onset multi-system inflammatory disease. Anesth Analg 105:351-7. 6. Louie GH, Chitkara P, Ward MM (2008) Relapse of sarcoidosis upon treatment with etanercept. Ann Rheum Dise 67:896-8. 7. Ward MM (2007) Association scan of 14,500 nsSNPs in four common diseases identifies variants involved in autoimmunity (2007) Nat Genet 39:1329-37. 8. Ward MM (2007) Interpreting measurements of physical function in clinical trials. Ann Rheum Dis 66 Suppl 3:iii32-4. 9. Ward MM, Raveille JD, Learch TJ, Davis JC, Weisman MH (2008) Occupational physical activities and long-term functional and radiographic outcomes in patients with ankylosing spondylitis. Arthritis Rheum 59:822-32. 10. Ward MM, Reveille JD, Learch TJ, Davis JC, Weisman MH (2008) Impact of ankylosing spondylitis on work and family life: comparisons with the US population. Arthritis Rheum 59:497-503. 11. Illei GG (2007) The clinical impact of neuropsychiatric manifestations in early systemic lupus erythematosus. Nat Clin Pract Rheumatol 3:428-9. 12. Illei GG, Yarboro CH, Kuroiwa T, Schlimgen R, Austin HA, Tisdale JF, Chitkara P, Fleisher T, Klippel JH, Balow JE, Boumpas DT (2007) Long-term effects of combination treatment with fludarabine and low-dose pulse cyclophosphamide in patients with lupus nephritis. Rheumatology (Oxford) 46:952-6.

该项目为以下临床方案提供了研究基础设施支持： 91-AR-0196多发性肌炎、皮肌炎和相关疾病的自然史和发病机制研究 94-AR-0066系统性红斑狼疮（SLE）的发病机制和自然史研究 94-AR-0105家族性地中海热和相关疾病的遗传学和病理生理学 99-D-0070 唾液腺功能障碍和干燥综合征的自然史 00-AR-0222关节炎和相关疾病的发病机制和自然史研究 01-AR-0227少数民族社区风湿病的自然史 02-AR-0156一项在皮肌炎和多发性肌炎患者中评价英夫利西单抗的随机、双盲、安慰剂对照试验 03-AR-0130强直性脊柱炎严重程度的遗传决定因素-横断面研究 03-AR-0131强直性脊柱炎严重程度的遗传决定因素-纵向研究 03-AR-0133风湿性关节炎的临床重要变化 03-AR-0173新生儿发病多系统炎性疾病（NOMID）的自然史和发病机制研究 03-AR-0298 IL-1受体拮抗剂Anakinra/Kineret在新生儿发病多系统炎性疾病（NOMID/CINCA综合征）患者中的初步研究 04-AR-0205强直性脊柱炎脊柱融合术的进展 05-AR-0014一项在自身炎性疾病成人受试者中进行的IL-1 Trap的初步开放标签研究：一种研究发病机制的治疗方法 07-E-0012 利妥昔单抗治疗难治性成人和青少年皮肌炎（DM）和多发性肌炎（PM） 08-AR-0008系统性红斑狼疮女性样本中的胰岛素抵抗和动脉粥样硬化 除了出版物部分列出的手稿外，还有一些其他已发表的论文，这些论文基于通过该项目提供的临床支持服务。 它们包括： 1. Hill SC，Namde M，Dwyer A，Poznanski A，Canna S，Goldbach-Mansky R（2007）新生儿发病多系统炎性疾病的关节病（NOMID/CINCA）。 Pediatr Radiol 37：145-52. 2. 杜里亚J、Magalnick M、Alli S、Yao L、Wilson M、Goldbach-Mansky R（2008）半自动三维分割软件，用于量化腕关节CT扫描的腕骨体积变化，以评估关节炎。 医学物理35：2321-30。 3. Glaser RL，Goldbach-Mansky R（2008）自体炎性疾病的谱：最近的实验室到床边观察。 Curr Opin Rheumiol 20：66-75. 4. Blackman MR，Muniyappa R，Wilson M，Moquin BE，Baldwin HL，Wong KA，Snyder C，Magalnick M，Alli S，Reynolds J，Steinber SM，Goldbach-Mansky R（2007）Diurnal secretion of growth hormone，cortisol，and dehydroepiandrosterone in pre-and perimenetry women with active rheumatoid arthritis：a pilot case-control study. 关节炎治疗研究9：R73。 5. Lauro CF、Goldbach-Mansky R、施密特M、Quezado ZM（2007）脑出血性多系统炎性疾病患儿的麻醉管理。 Anesth Analg 105：351-7. 6. Louie GH，Chitkara P，Ward MM（2008）依那西普治疗后结节病复发。 Ann Rheum Dise 67：896-8. 7. Ward MM（2007）Association scan of 14，500 nsSNP in four common diseases identified variants involved in autoimmunity（2007）Nat Genet 39：1329-37. 8. Ward MM（2007）解释临床试验中身体功能的测量。 Ann Rheum Dis 66 Suppl 3：iii32-4. 9. Ward MM，Raveille JD，Lampton TJ，Davis JC，Weisman MH（2008）强直性脊柱炎患者的职业体力活动和长期功能和影像学结局。 Arthritis Rheum 59：822-32. 10. Ward MM，Reveille JD，Lampton TJ，Davis JC，Weisman MH（2008）强直性脊柱炎对工作和家庭生活的影响：与美国人口的比较。 Arthritis Rheum 59：497-503. 11. Illei GG（2007）早期系统性红斑狼疮神经精神表现的临床影响。 Nat Clin Pract Rheumatol 3：428-9. 12. Illei GG，Yarboro CH，Kuroiwa T，Schlimgen R，Austin HA，Tisdale JF，Chitkara P，Fleurt T，Klippel JH，Balow JE，Boumpas DT（2007）狼疮肾炎患者氟达拉滨和低剂量环磷酰胺脉冲联合治疗的长期效果。 Rheumatology（Oxford）46：952-6.