Clinical Support Services for the NIAMS Intramural Research Program

NIAMS 校内研究项目的临床支持服务

• 批准号: 7732845
• 负责人: Daniel Kastner
• 金额: $ 338.95万
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732845
• 关键词: Adult; Alli; Ambulatory Care Facilities; Anesthetics; Ankylosing spondylitis; Appointments and Schedules; Arthritis; Atherosclerosis; Autoimmunity; Case-Control Studies; Child; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Communities; Community Health Centers; Computer software; Condition; Contracts; Cross-Sectional Studies; Cyclophosphamide; Databases; Dermatomyositis; Disease; District of Columbia; Dose; Etanercept; Familial Mediterranean Fever; Family; Functional disorder; Genetic; Genetic Determinism; Genets; Hospitalists; Hydrocortisone; Inflammatory; Insulin Resistance; Interleukin-1; Interleukin-1 Receptors; Intramural Research Program; Kineret; Label; Life; Long-Term Effects; Longitudinal Studies; Lupus Nephritis; Manuscripts; Measurement; Medical; Minority; Natural History; Neonatal; Numbers; Nurse Practitioners; Nursing Research; Occupational; Outcome; Paper; Pathogenesis; Patients; Perimenopause; Physical Function; Physical activity; Physicians; Physiologic pulse; Pilot Projects; Polymyositis; Population; Premenopause; Preparation; Publications; Publishing; Pulse taking; Randomized; Refractory; Relapse; Research; Research Ethics Committees; Research Infrastructure; Research Support; Rheum; Rheumatism; Rheumatoid Arthritis; Rheumatology; Salivary Glands; Sampling; Sarcoidosis; Scanning; Services; Severities; Sjogren' s Syndrome; Somatotropin; Spinal Fusion; Syndrome; System; Systemic Lupus Erythematosus; Therapeutic; Training Programs; Translational Research; Travel; United States National Institutes of Health; Variant; Woman; Work; Wrist; X-Ray Computed Tomography; anakinra; austin; base; bench to bedside; carpus bone; cost; dehydroepiandrosterone; double-blind placebo controlled trial; fludarabine; infliximab; neuropsychiatry; programs; rituximab; ward

This project has provided research infrastructure support for the following clinical protocols: 91-AR-0196 Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases 94-AR-0066 Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE) 94-AR-0105 Genetics and Pathophysiology of Familial Mediterranean Fever and Related Disorders 99-D-0070 Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome 00-AR-0222 Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions 01-AR-0227 Natural History of Rheumatic Disease in Minority Communities 02-AR-0156 A Randomized, Double-Blind, Placebo-Controlled Trial of Infliximab in Patients with Dermatomyositis and Polymyositis 03-AR-0130 Genetic Determinants of Ankylosing Spondylitis Severity - Cross Sectional Study 03-AR-0131 Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study 03-AR-0133 Clinically Important Changes in Rheumatoid Arthritis 03-AR-0173 Studies of the Natural History and Pathogenesis of Neonatal Onset Multisystem Inflammatory Disease (NOMID) 03-AR-0298 A Pilot Study of the IL-1 Receptor Antagonist Anakinra/Kineret in Patients with Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) 04-AR-0205 Progression of Spinal Fusion in Ankylosing Spondylitis 05-AR-0014 A Pilot Open-Label Study of IL-1 Trap in Adult Subjects with Autoinflammatory Disease: A Therapeutic Approach to Study Pathogenesis 07-E-0012 Rituximab in the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Polymyositis (PM) 08-AR-0008 Insulin Resistance and Atherosclerosis in a Sample of Women with Systemic Lupus Erythematosus In addition to the manuscripts listed in the Publications section, there are a number of other published papers that are based upon clinical support services provided through this project. They include: 1. Hill SC, Namde M, Dwyer A, Poznanski A, Canna S, Goldbach-Mansky R (2007) Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA). Pediatr Radiol 37:145-52. 2. Duryea J, Magalnick M, Alli S, Yao L, Wilson M, Goldbach-Mansky R (2008) Semiautomated three-dimensional segmentation software to quantify carpal bone volume changes on wrist CT scans for arthritis assessment. Med Phys 35:2321-30. 3. Glaser RL, Goldbach-Mansky R (2008) The spectrum of autoinflammatory diseases: recent bench to bedside observations. Curr Opin Rheumatol 20:66-75. 4. Blackman MR, Muniyappa R, Wilson M, Moquin BE, Baldwin HL, Wong KA, Snyder C, Magalnick M, Alli S, Reynolds J, Steinber SM, Goldbach-Mansky R (2007) Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study. Arthritis Res Ther 9:R73. 5. Lauro CF, Goldbach-Mansky R, Schmidt M, Quezado ZM (2007) The anesthetic management of children with neonatal-onset multi-system inflammatory disease. Anesth Analg 105:351-7. 6. Louie GH, Chitkara P, Ward MM (2008) Relapse of sarcoidosis upon treatment with etanercept. Ann Rheum Dise 67:896-8. 7. Ward MM (2007) Association scan of 14,500 nsSNPs in four common diseases identifies variants involved in autoimmunity (2007) Nat Genet 39:1329-37. 8. Ward MM (2007) Interpreting measurements of physical function in clinical trials. Ann Rheum Dis 66 Suppl 3:iii32-4. 9. Ward MM, Raveille JD, Learch TJ, Davis JC, Weisman MH (2008) Occupational physical activities and long-term functional and radiographic outcomes in patients with ankylosing spondylitis. Arthritis Rheum 59:822-32. 10. Ward MM, Reveille JD, Learch TJ, Davis JC, Weisman MH (2008) Impact of ankylosing spondylitis on work and family life: comparisons with the US population. Arthritis Rheum 59:497-503. 11. Illei GG (2007) The clinical impact of neuropsychiatric manifestations in early systemic lupus erythematosus. Nat Clin Pract Rheumatol 3:428-9. 12. Illei GG, Yarboro CH, Kuroiwa T, Schlimgen R, Austin HA, Tisdale JF, Chitkara P, Fleisher T, Klippel JH, Balow JE, Boumpas DT (2007) Long-term effects of combination treatment with fludarabine and low-dose pulse cyclophosphamide in patients with lupus nephritis. Rheumatology (Oxford) 46:952-6.

本项目为以下临床方案提供了研究基础设施支持：